KEGG   ENZYME: 1.4.3.4Help
Entry
EC 1.4.3.4                  Enzyme                                 

Name
monoamine oxidase;
adrenalin oxidase;
adrenaline oxidase;
amine oxidase (ambiguous);
amine oxidase (flavin-containing);
amine:oxygen oxidoreductase (deaminating) (flavin-containing);
epinephrine oxidase;
MAO;
MAO A;
MAO B;
MAO-A;
MAO-B;
monoamine oxidase A;
monoamine oxidase B;
monoamine:O2 oxidoreductase (deaminating);
polyamine oxidase (ambiguous);
serotonin deaminase;
spermidine oxidase (ambiguous);
spermine oxidase (ambiguous);
tyraminase;
tyramine oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
amine:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN:R11354]
Reaction(KEGG)
Substrate
RCH2NHR' [CPD:C21299];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
RCHO [CPD:C00071];
R'NH2 [CPD:C21300];
H2O2 [CPD:C00027]
Comment
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.
History
EC 1.4.3.4 created 1961, modified 1983 (EC 1.4.3.9 created 1972, incorporated 1984), modified 2008
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00274  monoamine oxidase
Genes
HSA: 4128(MAOA) 4129(MAOB)
PTR: 465588(MAOB) 743285(MAOA)
PPS: 100984839(MAOB) 100985360(MAOA)
GGO: 101141308(MAOA) 101141911(MAOB)
PON: 100171761(MAOB) 100171783(MAOA)
NLE: 100589976(MAOA) 100590311(MAOB)
MCC: 708371(MAOA) 708468(MAOB)
MCF: 101925100(MAOB) 102118475 102146667(MAOA)
CSAB: 103231841(MAOA) 103231842(MAOB)
RRO: 104653770(MAOA) 104653771(MAOB) 104668726
CJC: 100403544(MAOB) 100407187(MAOA)
SBQ: 101027505(MAOB) 101040195
MMU: 109731(Maob) 17161(Maoa)
RNO: 25750(Maob) 29253(Maoa)
CGE: 100759648(Maob) 100760815(Maoa)
NGI: 103732590(Maob) 103742177(Maoa)
HGL: 101724899(Maob) 101725537(Maoa)
OCU: 100345623(MAOA) 100357007(MAOB)
TUP: 102479142(MAOB) 102479553(MAOA)
CFA: 403450(MAOA) 403451(MAOB)
AML: 100468604(MAOB) 100468852
UMR: 103679199(MAOB) 103679200
ORO: 101371621(MAOB) 101371926(MAOA)
FCA: 101091848(MAOA) 101092086(MAOB)
PTG: 102961494(MAOB) 102961954(MAOA) 102962242
AJU: 106972520(MAOA) 106972743(MAOB)
BTA: 281293(MAOA) 338445(MAOB)
BOM: 102278212(MAOA) 102278499(MAOB)
BIU: 109555289(MAOA) 109555337(MAOB)
PHD: 102337330(MAOB) 102337685(MAOA)
OAS: 101106401(MAOA) 101106659(MAOB)
SSC: 414424(MAOA) 414909(MAOB)
CFR: 102520250(MAOB) 102520659(MAOA)
CDK: 105085263(MAOA) 105085264(MAOB)
BACU: 103019850(MAOB) 103020125(MAOA)
LVE: 103076372(MAOB) 103076637(MAOA)
OOR: 101272484(MAOB) 101272725(MAOA)
ECB: 100033867(MAOA) 100033868(MAOB)
EPZ: 103540167(MAOA) 103565966(MAOB)
EAI: 106838325(MAOB) 106838326(MAOA)
MYB: 102262229(MAOA) 102262546(MAOB)
MYD: 102765926(MAOB) 102766211(MAOA)
HAI: 109385886(MAOB) 109386506(MAOA)
RSS: 109438127(MAOA) 109438128(MAOB)
PALE: 102878757(MAOA) 102879012(MAOB)
LAV: 100661468(MAOB) 100662037
MDO: 100027805(MAOB) 100618242(MAOA)
SHR: 100919856 100920121(MAOA)
OAA: 100081953(MAOB) 100082010(MAOA)
GGA: 418561(MAOB) 418563(MAOA)
CJO: 107324272(MAOB) 107324276(MAOA)
APLA: 101792808(MAOB) 101793000(MAOA)
TGU: 100219032 100221249(MAOA) 100223232(MAOB)
GFR: 102042435(MAOB) 102042598(MAOA)
FAB: 101808185(MAOB) 101808381(MAOA)
PHI: 102103925(MAOB) 102105564(MAOA)
FPG: 101910636(MAOB) 101922822(MAOA)
FCH: 102056467(MAOA) 102058351(MAOB)
AAM: 106483688(MAOB) 106483689
ASN: 102369090(MAOA) 102375827
AMJ: 102561407(MAOA) 102561639(MAOB)
PSS: 102448543(MAOA) 102458176
CMY: 102935766(MAOA) 102945341(MAOB)
CPIC: 101932805(MAOA) 101933084(MAOB)
XLA: 108708197 108709414 108709415 446968(maob.L) 495197(maoa.L)
XTR: 100145726(maoa) 100494267(maob) 100495198
DRE: 404730(mao) 558050(si:ch211-127i16.2)
AMEX: 103033722(maob) 103039919
TRU: 101063937(maob) 105416526
OLA: 101167909(maob) 101175668
XMA: 102228206(maob) 106699643
PRET: 103474005 103481637(maob)
KMR: 108241385 108243545(maob)
CSEM: 103391527(maob)
LCF: 108884103 108897619(maob)
SDU: 111237990(maob) 111238498
HCQ: 109520017
ELS: 105021930(maob) 105024174
CMK: 103177252 103183911(maob)
CIN: 100178944
DME: Dmel_CG13611(CG13611)
MDE: 101896944
AAG: 5563688
BIM: 105681182
BTER: 105666363
MDL: 103577639
TCA: 103314476
BMOR: 101737288
PMAC: 106716078
AQU: 100632498
MNG: MNEG_6608
SSCK: SPSK_07297
MBE: MBM_04717
ANG: ANI_1_1832104(An12g05210) ANI_1_2298014(An01g01840) ANI_1_2304104(An12g10150) ANI_1_830114(An13g03560)
CNE: CNL05890
CNB: CNBI0930
DDI: DDB_G0272582(maoB-1) DDB_G0272584(maoC-1) DDB_G0273991(maoC-2) DDB_G0273993(maoB-2) DDB_G0288541(maoA)
DFA: DFA_02755(maoD) DFA_05004(maoA) DFA_05170
SMIN: v1.2.029069.t1(symbB.v1.2.029069.t1) v1.2.033123.t1(symbB.v1.2.033123.t1)
XCC: XCC3278
XCB: XC_0886
XCA: xcc-b100_0906(lao)
XCP: XCR_3620
XCV: XCV3541
XAX: XACM_3313
XAC: XAC3426
XOM: XOO1119(XOO1119)
XOR: XOC_3685
XPH: XppCFBP6546_17070(XppCFBP6546P_17070)
PSD: DSC_03425
VTA: B0464
PAE: PA0421
PAEV: N297_432
PAEI: N296_432
PAEP: PA1S_02135
PAEM: U769_02170
PAEL: T223_02130
PAEG: AI22_01765
PAEC: M802_431
PAEO: M801_432
PPSE: BN5_0151(MaoA_B)
PCQ: PcP3B5_05610(pao)
PPU: PP_4983
PPF: Pput_4856
PPT: PPS_4827
PPI: YSA_04067
PPX: T1E_1125
PPUH: B479_24380
PPUN: PP4_19560(lao) PP4_50490
PPUD: DW66_5217
PMON: X969_23840
PMOT: X970_23475
PSYR: N018_02180
PFL: PFL_1384
PPRO: PPC_1438
PFS: PFLU_4065
PFB: VO64_1140
PMAN: OU5_3891
PEN: PSEEN5045
PSA: PST_1610
PKC: PKB_0440
PSEM: TO66_18665
PSOS: POS17_1405
PANR: A7J50_3729
PSIL: PMA3_28285
PAR: Psyc_1152
PAT: Patl_1720
PSM: PSM_A1719
PART: PARC_a1657
GNI: GNIT_0252
GPS: C427_3115
PIN: Ping_1791
SAGA: M5M_13340
MICC: AUP74_00316(rebO) AUP74_02000(puo)
LFA: LFA_0576(aofH)
LOK: Loa_00117
GAI: IMCC3135_33845(aofH)
HCO: LOKO_02360(puo)
APAC: S7S_17000
RPI: Rpic_4331
REH: H16_A0831(maoB) H16_A0845(lao1)
BXE: Bxe_B1535
BXB: DR64_6842
PPUL: RO07_06240
PSPU: NA29_21510
PLG: NCTC10937_00437(puo)
BPT: Bpet4206
PNA: Pnap_1588
VEI: Veis_0808
CTES: O987_25850
LCH: Lcho_1418
AZO: azo2784
AOA: dqs_2919
DOL: Dole_0266
DAL: Dalk_2091
MXA: MXAN_4930
CCX: COCOR_00756(aofH)
SCL: sce9156
HOH: Hoch_5789
BBA: Bd2540
BBAT: Bdt_2476
BBW: BDW_09355
BBAC: EP01_08845
PACA: ID47_07820
MLO: mll3668
PLA: Plav_2453
SME: SM_b21110
ARA: Arad_0120
AVI: Avi_2873
BJA: blr0541
BRS: S23_02900
BRAD: BF49_0306
RPA: RPA0409
RPB: RPB_0104
RPC: RPC_0038
RPD: RPD_0698
RPE: RPE_0041
RPT: Rpal_0413
NWI: Nwi_0489
NHA: Nham_0613
OCA: OCAR_4306
VGO: GJW-30_1_00702(rebO_1) GJW-30_1_02554(puo)
SNO: Snov_3093
MEX: Mext_4367
MDI: METDI5413
MCH: Mchl_4843
MPO: Mpop_0312
MET: M446_3036
MNO: Mnod_4579
MOR: MOC_0996
MSC: BN69_2636
HDI: HDIA_2875(pao)
CCR: CC_2793
RDE: RD1_0535
KVU: EIO_2949
SMAZ: LH19_21290
SPHB: EP837_02856(aofH)
SPHT: K426_22789
SFLA: SPHFLASMR4Y_02624(puo)
ANH: A6F65_00047(rebO)
ACR: Acry_1970
GDI: GDI2456
GDJ: Gdia_0704
GXL: H845_1285
ASZ: ASN_2204
RCE: RC1_3921
BSR: I33_2136
BSL: A7A1_2773
BSH: BSU6051_19020(yobN)
BSUT: BSUB_02048(yobN)
BSUL: BSUA_02048(yobN)
BSUS: Q433_11340
BSS: BSUW23_10185(yobN)
BST: GYO_2300
BSO: BSNT_08461(yobN)
BSQ: B657_19020(yobN)
BSX: C663_1953
BLH: BaLi_c19750(yobN)
BTG: BTB_c19930(yobN1) BTB_c20850(yobN2)
BWW: bwei_2998 bwei_3087(yobN)
BMYC: DJ92_4579
BJS: MY9_2059
BACY: QF06_08630
BACL: BS34A_21100(yobN)
BALM: BsLM_2020
BGY: BGLY_2226(yobN)
BKW: BkAM31D_12655(puo)
BBEV: BBEV_2760(aofH)
OIH: OB1296
GTN: GTNG_0259
GGH: GHH_c03180(yobN)
GEA: GARCT_00339(rebO)
AAMY: GFC30_2310
EAN: Eab7_1342
PMW: B2K_07800
CBO: CBO1197
CBA: CLB_1227
CBH: CLC_1239
CBY: CLM_1349
CBL: CLK_0635
CBK: CLL_A2339
CBB: CLD_3371
CBI: CLJ_B1237
CBF: CLI_1280
CBM: CBF_1253
CSB: CLSA_c41800(yobN)
CSQ: CSCA_0805
CCE: Ccel_1778
CPY: Cphy_2915
SGY: Sgly_1921
TOC: Toce_0324
SCLA: SCLARK_00388(crtI)
MTU: Rv3170(aofH)
MTV: RVBD_3170
MTC: MT3259
MRA: MRA_3203(aofH)
MTUR: CFBS_3348(aofH)
MTO: MTCTRI2_3233(aofH)
MTD: UDA_3170(aofH)
MTN: ERDMAN_3471(aofH)
MTUE: J114_16965
MTUH: I917_22280
MTUL: TBHG_03102
MTUT: HKBT1_3334(aofH)
MTUU: HKBT2_3340(aofH)
MTQ: HKBS1_3345(aofH)
MBO: BQ2027_MB3195(aofH)
MBB: BCG_3194(aofH)
MBT: JTY_3189(aofH)
MBM: BCGMEX_3191(aofH)
MAF: MAF_31790(aofH)
MMIC: RN08_3493
MCE: MCAN_31851(aofH)
MCQ: BN44_60679(aofH)
MCV: BN43_60157(aofH)
MCX: BN42_41214(aofH)
MCZ: BN45_60177(aofH)
MPA: MAP_3228
MAO: MAP4_0560
MAVI: RC58_02720
MAVU: RE97_02725
MAV: MAV_4062
MLP: MLM_3257
MUL: MUL_1281(aofH_1) MUL_2487(aofH)
MMC: Mmcs_1556
MKM: Mkms_1580
MJL: Mjls_1526
MMI: MMAR_1389(aofH) MMAR_3362(aofH_1)
MMAE: MMARE11_13560(aofH) MMARE11_32620(aofH_1)
MLI: MULP_01560 MULP_03628(aofH_1)
MSG: MSMEI_1990(aofH)
MPHL: MPHLCCUG_01728(puo)
MTHN: 4412656_01325(puo_1) 4412656_02369(puo_2)
MAB: MAB_2659
RER: RER_12600(lao)
REY: O5Y_05870
RHB: NY08_4009
RFA: A3L23_02178(puo_2)
RHS: A3Q41_01203(puo_1)
RHU: A3Q40_00164(puo)
GBR: Gbro_2005
TPR: Tpau_2259
SALB: XNR_5488
SVE: SVEN_1413
SLE: sle_03730(sle_03730) sle_53560(sle_53560)
SMAL: SMALA_0957
SLAU: SLA_4885
SFK: KY5_4309c
KSK: KSE_60570 KSE_65730(gox)
MTS: MTES_1160
KRH: KRH_17330
LMOI: VV02_18590
XCE: Xcel_0068
PAW: PAZ_c02720(aofH)
PACC: PAC1_01340
PACH: PAGK_0281
CACN: RN83_01735
CGRN: 4412665_00236(puo)
PFR: PFREUD_20440(mao)
PFRE: RM25_1950
ACIJ: JS278_00629(aofH)
MPH: MLP_19140
NCA: Noca_4000
NDK: I601_0540(puo_1) I601_2810(puo_2)
NAL: B005_4112
TCU: Tcur_3201
SEN: SACE_4116(aofH) SACE_4854
AMD: AMED_3481
AMN: RAM_17705
AMM: AMES_3442
AMZ: B737_3442
AOI: AORI_4739
PSEH: XF36_16920
ACTI: UA75_08495
ACAD: UA74_08520
AHG: AHOG_07990(rebO)
MIL: ML5_4821
ACTN: L083_4283
AFS: AFR_18170
SNA: Snas_0821
SYN: slr0782
SYY: SYNGTS_2177(slr0782)
SYT: SYNGTI_2176(slr0782)
SYS: SYNPCCN_2175(slr0782)
SYQ: SYNPCCP_2175(slr0782)
SYC: syc1144_c
MAR: MAE_40250
MPK: VL20_2889
TER: Tery_1366
CAU: Caur_1376
CAG: Cagg_2535
DRA: DR_A0274
DGE: Dgeo_1827
TRA: Trad_0847
OTE: Oter_1328
OBG: Verru16b_01010(rebO)
PIR: VN12_15485(puo_2)
PLM: Plim_2381
SACI: Sinac_0279
PBOR: BSF38_02596(puo)
LBF: LBF_1077(aofA)
GBA: J421_1411
SRU: SRU_0427
SRM: SRM_00504
SMIZ: 4412673_01663(puo)
MUC: MuYL_3363
PSEZ: HME7025_00382(aofH)
FLM: MY04_1192
GFO: GFO_1974
FJO: Fjoh_3835
MARM: YQ22_13775
CBAL: M667_04525
CBAT: M666_04535
NDO: DDD_3189
AALG: AREALGSMS7_04354(rebO)
NJA: NSJP_2584
NMG: Nmag_2893
 » show all
Taxonomy
Reference
1
  Authors
Blaschko, H.
  Title
Amine oxidase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 337-351.
Reference
2  [PMID:2644497]
  Authors
Dostert PL, Strolin Benedetti M, Tipton KF.
  Title
Interactions of monoamine oxidase with substrates and inhibitors.
  Journal
Med Res Rev 9:45-89 (1989)
DOI:10.1002/med.2610090104
Reference
3  [PMID:15279562]
  Authors
Edmondson DE, Mattevi A, Binda C, Li M, Hubalek F.
  Title
Structure and mechanism of monoamine oxidase.
  Journal
Curr Med Chem 11:1983-93 (2004)
Reference
4  [PMID:15279563]
  Authors
Shih JC, Chen K.
  Title
Regulation of MAO-A and MAO-B gene expression.
  Journal
Curr Med Chem 11:1995-2005 (2004)
Reference
5  [PMID:15279561]
  Authors
Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J.
  Title
Monoamine oxidases: certainties and uncertainties.
  Journal
Curr Med Chem 11:1965-82 (2004)
Reference
6  [PMID:16129825]
  Authors
De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A.
  Title
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.
  Journal
Proc Natl Acad Sci U S A 102:12684-9 (2005)
DOI:10.1073/pnas.0505975102
  Sequence
[hsa:4128 4129]
Reference
7  [PMID:16552415]
  Authors
Youdim MB, Edmondson D, Tipton KF.
  Title
The therapeutic potential of monoamine oxidase inhibitors.
  Journal
Nat Rev Neurosci 7:295-309 (2006)
DOI:10.1038/nrn1883
Reference
8  [PMID:16402116]
  Authors
Youdim MB, Bakhle YS.
  Title
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness.
  Journal
Br J Pharmacol 147 Suppl 1:S287-96 (2006)
DOI:10.1038/sj.bjp.0706464
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.4
IUBMB Enzyme Nomenclature: 1.4.3.4
ExPASy - ENZYME nomenclature database: 1.4.3.4
UM-BBD (Biocatalysis/Biodegradation Database): 1.4.3.4
BRENDA, the Enzyme Database: 1.4.3.4
CAS: 9001-66-5

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