| Entry |
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| Name |
monoamine oxidase;
adrenalin oxidase;
adrenaline oxidase;
amine oxidase (ambiguous);
amine oxidase (flavin-containing);
amine:oxygen oxidoreductase (deaminating) (flavin-containing);
epinephrine oxidase;
MAO;
MAO A;
MAO B;
MAO-A;
MAO-B;
monoamine oxidase A;
monoamine oxidase B;
monoamine:O2 oxidoreductase (deaminating);
polyamine oxidase (ambiguous);
serotonin deaminase;
spermidine oxidase (ambiguous);
spermine oxidase (ambiguous);
tyraminase;
tyramine oxidase
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
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| Sysname |
amine:oxygen oxidoreductase (deaminating)
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| Reaction(IUBMB) |
RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 [RN: R11354]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.
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| History |
EC 1.4.3.4 created 1961, modified 1983 (EC 1.4.3.9 created 1972, incorporated 1984), modified 2008
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| Pathway |
| ec00260 | Glycine, serine and threonine metabolism |
| ec00330 | Arginine and proline metabolism |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec00982 | Drug metabolism - cytochrome P450 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Blaschko, H. |
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| Title |
Amine oxidase. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 337-351. |
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| Reference |
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| Authors |
Dostert PL, Strolin Benedetti M, Tipton KF. |
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| Title |
Interactions of monoamine oxidase with substrates and inhibitors. |
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| Journal |
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| Reference |
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| Authors |
Edmondson DE, Mattevi A, Binda C, Li M, Hubalek F. |
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| Title |
Structure and mechanism of monoamine oxidase. |
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| Journal |
Curr Med Chem 11:1983-93 (2004) |
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| Reference |
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| Authors |
Shih JC, Chen K. |
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| Title |
Regulation of MAO-A and MAO-B gene expression. |
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| Journal |
Curr Med Chem 11:1995-2005 (2004) |
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| Reference |
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| Authors |
Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J. |
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| Title |
Monoamine oxidases: certainties and uncertainties. |
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| Journal |
Curr Med Chem 11:1965-82 (2004) |
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| Reference |
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| Authors |
De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A. |
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| Title |
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Youdim MB, Edmondson D, Tipton KF. |
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| Title |
The therapeutic potential of monoamine oxidase inhibitors. |
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| Journal |
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| Reference |
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| Authors |
Youdim MB, Bakhle YS. |
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| Title |
Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.4.3.4 |
| ExPASy - ENZYME nomenclature database: | 1.4.3.4 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.4.3.4 |
| BRENDA, the Enzyme Database: | 1.4.3.4 |
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