KEGG   ENZYME: 1.5.1.10Help
Entry
EC 1.5.1.10                 Enzyme                                 

Name
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.10 created 1972, modified 2011
Pathway
ec00300  Lysine biosynthesis
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00293  saccharopine dehydrogenase (NADP+, L-glutamate forming)
Genes
MDM: 103418228
DCR: 108212728
SCE: YNR050C(LYS9)
AGO: AGOS_ABR116C
ERC: Ecym_7008
KLA: KLLA0_C18744g
KMX: KLMA_40016(LYS9)
LTH: KLTH0A07590g
VPO: Kpol_1028p12
ZRO: ZYRO0D17578g
NCS: NCAS_0A05670(NCAS0A05670)
NDI: NDAI_0K02690(NDAI0K02690)
TPF: TPHA_0M02120(TPHA0M02120)
TBL: TBLA_0F00190(TBLA0F00190)
TDL: TDEL_0A07910(TDEL0A07910)
KAF: KAFR_0C04810(KAFR0C04810)
PIC: PICST_70210(LYS9)
CAL: CAALFM_C306590WA(LYS9)
CAUR: QG37_05955
SLB: AWJ20_2696(LYS9)
NCR: NCU03748
NTE: NEUTE1DRAFT58317(NEUTE1DRAFT_58317)
MGR: MGG_17041
SSCK: SPSK_03190
MAW: MAC_01390
MAJ: MAA_08309
CMT: CCM_00396
BFU: BCIN_03g09280(Bclys9)
MBE: MBM_03741
ANI: AN5601.2
ANG: ANI_1_3268014(An01g13590) ANI_1_878184(An04g05260)
PCS: Pc22g05800(Lys7)
ABE: ARB_02329
TVE: TRV_04693
PTE: PTT_10655
ZTR: MYCGRDRAFT_110462(LYS9)
CNE: CNG01150
CNB: CNBG3640
MGL: MGL_1529
DDI: DDB_G0285267(sdh)
SMIN: v1.2.003859.t1(symbB.v1.2.003859.t1)
KKO: Kkor_1620
PGD: Gal_03331
TLI: Tlie_0256
DORI: FH5T_01700
BLQ: L21SP5_01436(lysDH)
CABY: Cabys_3946
 » show all
Taxonomy
Reference
1  [PMID:4380448]
  Authors
Jones EE, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
  Journal
J Biol Chem 241:3430-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.10
IUBMB Enzyme Nomenclature: 1.5.1.10
ExPASy - ENZYME nomenclature database: 1.5.1.10
BRENDA, the Enzyme Database: 1.5.1.10
CAS: 9033-55-0

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