KEGG   ENZYME: 1.5.1.15Help
Entry
EC 1.5.1.15                 Enzyme                                 

Name
methylenetetrahydrofolate dehydrogenase (NAD+);
methylenetetrahydrofolate dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+ [RN:R01218]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydrofolate [CPD:C00143];
NAD+ [CPD:C00003]
Product
5,10-methenyltetrahydrofolate [CPD:C00445];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.5.1.15 created 1978
Pathway
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K00295  methylenetetrahydrofolate dehydrogenase (NAD+)
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase
Genes
HSA: 10797(MTHFD2) 441024(MTHFD2L)
PTR: 459331(MTHFD2) 461253(MTHFD2L)
PPS: 100974548(MTHFD2L) 100994215(MTHFD2)
GGO: 101139170(MTHFD2L) 101146472(MTHFD2)
PON: 100442117(MTHFD2) 100445055(MTHFD2L)
NLE: 100584729(MTHFD2) 100589055(MTHFD2L) 100590349
MCC: 702907(MTHFD2L) 714974(MTHFD2)
MCF: 102119606(MTHFD2L) 102144180(MTHFD2)
CSAB: 103220037(MTHFD2) 103235800(MTHFD2L)
RRO: 104658885(MTHFD2L) 104674805(MTHFD2)
RBB: 108515812(MTHFD2L) 108520674(MTHFD2) 108532678
CJC: 100389511(MTHFD2L) 100402525(MTHFD2)
SBQ: 101027806(MTHFD2) 101048869(MTHFD2L) 101052018
MMU: 17768(Mthfd2) 665563(Mthfd2l)
RNO: 305248(Mthfd2l) 680308(Mthfd2)
CGE: 100760811(Mthfd2l) 100770086(Mthfd2)
NGI: 103727002(Mthfd2) 103742471(Mthfd2l)
HGL: 101703156(Mthfd2l) 101705997(Mthfd2)
CCAN: 109681115(Mthfd2l) 109688133(Mthfd2)
OCU: 100344170(MTHFD2L) 100349062(MTHFD2)
TUP: 102468110(MTHFD2L) 102477024(MTHFD2)
CFA: 482197(MTHFD2L) 483107(MTHFD2)
AML: 100463985(MTHFD2L) 100475974(MTHFD2)
UMR: 103665392(MTHFD2L) 103671402(MTHFD2)
ORO: 101365960(MTHFD2L) 101375555(MTHFD2)
FCA: 101083836(MTHFD2) 101093354(MTHFD2L)
PTG: 102961104(MTHFD2) 102967232(MTHFD2L)
AJU: 106982039(MTHFD2L) 106988599(MTHFD2)
BTA: 517539(MTHFD2) 536269(MTHFD2L)
BOM: 102272253(MTHFD2L) 102277964(MTHFD2)
BIU: 109560580(MTHFD2L) 109565920(MTHFD2)
PHD: 102340212(MTHFD2) 102344381
CHX: 102179276 102184159(MTHFD2)
OAS: 100137069(MTHFD2) 101104908(MTHFD2L) 101107147
SSC: 100525706(MTHFD2L) 100737806(MTHFD2)
CFR: 102506350(MTHFD2) 102507186(MTHFD2L)
CDK: 105091387(MTHFD2L) 105096568(MTHFD2)
BACU: 102999576(MTHFD2) 103005088(MTHFD2L)
LVE: 103070308(MTHFD2L) 103080041(MTHFD2)
OOR: 101271285(MTHFD2) 101284968(MTHFD2L)
ECB: 100053990(MTHFD2) 100056425(MTHFD2L)
EPZ: 103564986(MTHFD2) 103565139(MTHFD2L)
EAI: 106823850(MTHFD2) 106846392(MTHFD2L)
MYB: 102241059(MTHFD2L) 102257615(MTHFD2)
MYD: 102754790(MTHFD2) 102755341(MTHFD2L)
HAI: 109371186(MTHFD2) 109371843(MTHFD2L)
RSS: 109440565(MTHFD2L) 109457428(MTHFD2)
PALE: 102884965(MTHFD2) 102885905(MTHFD2L)
LAV: 100656025(MTHFD2) 100662679(MTHFD2L)
MDO: 100023851(MTHFD2L) 100024210(MTHFD2)
SHR: 100915702(MTHFD2L) 100917387(MTHFD2)
OAA: 100081813(MTHFD2)
GGA: 426126(MTHFD2) 770327(MTHFD2L)
MGP: 100538988(MTHFD2) 100551458(MTHFD2L)
CJO: 107313487(MTHFD2L) 107323669(MTHFD2)
APLA: 101792957(MTHFD2) 101797763(MTHFD2L)
ACYG: 106041914(MTHFD2L) 106047654(MTHFD2)
TGU: 100224318(MTHFD2L) 100226198
GFR: 102034978(MTHFD2) 102038192(EPGN)
FAB: 101805811(MTHFD2) 101808409(MTHFD2L)
PHI: 102104850(MTHFD2) 102107685(MTHFD2L)
PMAJ: 107203094(MTHFD2L)
CCW: 104683768(MTHFD2) 104698281
FPG: 101913929(MTHFD2) 101919106(MTHFD2L)
FCH: 102045855(MTHFD2) 102057455(MTHFD2L)
CLV: 102087519(MTHFD2) 102090092
EGZ: 104130378(MTHFD2) 104131554(MTHFD2L)
ASN: 102380151(MTHFD2L) 102387286(MTHFD2)
AMJ: 102559087 102568648(MTHFD2L) 102576181(MTHFD2)
PSS: 102453272(MTHFD2) 102459482(MTHFD2L)
CMY: 102929848(MTHFD2) 102931470(MTHFD2L)
CPIC: 101931359(MTHFD2) 101935770(MTHFD2L)
ACS: 100553649(mthfd2l) 100566586(mthfd2)
PVT: 110072089(MTHFD2) 110090462(MTHFD2L)
PBI: 103051980(MTHFD2) 103060626
GJA: 107118751(MTHFD2)
XLA: 108711079 432317(mthfd2.L) 446641(mthfd2l.S)
XTR: 100170462(mthfd2) 100497864(mthfd2l)
NPR: 108784463(MTHFD2L) 108793886(MTHFD2)
DRE: 100004977(mthfd2)
IPU: 108255807(mthfd2)
AMEX: 103037572(mthfd2) 103042060
TRU: 101066384(mthfd2l) 101073406
LCO: 104920303(mthfd2) 104923005(mthfd2l) 109140161
NCC: 104962129(mthfd2l) 104962309(mthfd2)
OLA: 101160170(mthfd2) 101165643
PRET: 103469985 103470271(mthfd2)
NFU: 107394218(mthfd2) 107394299
BPEC: 110172444(mthfd2) 110175266
ELS: 105014522 105026116(mthfd2)
SFM: 108934776(mthfd2) 108938600(mthfd2l)
LCM: 102351616(MTHFD2) 102356358(MTHFD2L)
CMK: 103177682(mthfd2l) 103191574(mthfd2)
CIN: 100186867
SPU: 588966
APLC: 110973624
SKO: 100372318
DME: Dmel_CG18466(Nmdmc)
DSI: Dsimw501_GD20823(Dsim_GD20823)
MDE: 101893683
AAG: 5565520
AME: 551667
BIM: 100742580
BTER: 100648062
SOC: 105205751
AEC: 105152165
ACEP: 105625905
PBAR: 105431893
HST: 105186219
CFO: 105256248
LHU: 105671947
PGC: 109854289
NVI: 103316642
TCA: 662099
DPA: 109538981
NVL: 108559670
BMOR: 101741628
PMAC: 106709194
PRAP: 111003982
PXY: 105393725
API: 100164363
DNX: 107167708
ZNE: 110828188
FCD: 110848840
CEL: CELE_K07E3.3(dao-3)
CBR: CBG16896(Cbr-dao-3)
CRG: 105336517
MYI: 110446618
LAK: 106154809
AQU: 100640189
SCE: YKR080W(MTD1)
ERC: Ecym_4047
KMX: KLMA_10419(folD)
NCS: NCAS_0A03350(NCAS0A03350)
NDI: NDAI_0A03210(NDAI0A03210)
TPF: TPHA_0H01380(TPHA0H01380)
TBL: TBLA_0A09280(TBLA0A09280)
TDL: TDEL_0B02500(TDEL0B02500)
KAF: KAFR_0H00370(KAFR0H00370)
CAL: CAALFM_C404720WA(CaO19.3810)
CAUR: QG37_04994
SLB: AWJ20_1683(MTD1)
NCR: NCU00963
NTE: NEUTE1DRAFT90232(NEUTE1DRAFT_90232)
MGR: MGG_10834
SSCK: SPSK_09467
MAW: MAC_03188
MAJ: MAA_04282
CMT: CCM_02303
MBE: MBM_04386
ANI: AN1524.2
ANG: ANI_1_982144(An16g07400)
ABE: ARB_06549
TVE: TRV_04433
PTE: PTT_07593
CNE: CNF03710
CNB: CNBF1110
ABP: AGABI1DRAFT119972(AGABI1DRAFT_119972)
ABV: AGABI2DRAFT188587(AGABI2DRAFT_188587)
MGL: MGL_3825
DDI: DDB_G0277725(thfA)
DFA: DFA_11465(thfA)
SMIN: v1.2.027029.t1(symbB.v1.2.027029.t1)
SPAR: SPRG_18669
DEU: DBW_2270
 » show all
Taxonomy
Reference
1  [PMID:4153026]
  Authors
Moore MR, O'Brien WE, Ljungdahl LG.
  Title
Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum.
  Journal
J Biol Chem 249:5250-3 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.15
IUBMB Enzyme Nomenclature: 1.5.1.15
ExPASy - ENZYME nomenclature database: 1.5.1.15
BRENDA, the Enzyme Database: 1.5.1.15
CAS: 82062-90-6

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