KEGG   ENZYME: 1.5.1.18Help
Entry
EC 1.5.1.18                 Enzyme                                 

Name
ephedrine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-ephedrine:NAD+ 2-oxidoreductase
Reaction(IUBMB)
(-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+ [RN:R03614]
Reaction(KEGG)
Substrate
(-)-ephedrine [CPD:C01575];
NAD+ [CPD:C00003]
Product
(R)-2-methylimino-1-phenylpropan-1-ol [CPD:C04351];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The product immediately hydrolyses to methylamine and 1-hydroxy-1-phenylpropan-2-one. Acts on a number of related compounds including (-)-sympatol, (+)-pseudoephedrine and (+)-norephedrine.
History
EC 1.5.1.18 created 1984
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:7405363]
  Authors
Klamann E, Lingens F.
  Title
Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis.
  Journal
Z Naturforsch [C] 35:80-7 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.18
IUBMB Enzyme Nomenclature: 1.5.1.18
ExPASy - ENZYME nomenclature database: 1.5.1.18
BRENDA, the Enzyme Database: 1.5.1.18
CAS: 73508-06-2

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