KEGG   ENZYME: 1.5.1.21Help
Entry
EC 1.5.1.21                 Enzyme                                 

Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH);
Pyr2C reductase;
1,2-didehydropipecolate reductase;
P2C reductase;
1,2-didehydropipecolic reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
L-pipecolate:NADP+ 2-oxidoreductase;
DELTA1-piperideine-2-carboxylate reductase;
Delta1-piperideine-2-carboxylate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-pipecolate/L-proline:NADP+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NADP+ = 1-piperideine-2-carboxylate + NADPH + H+ [RN:R02203];
(2) L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ [RN:R01249]
Reaction(KEGG)
Substrate
L-pipecolate [CPD:C00408];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
History
EC 1.5.1.21 created 1984 (EC 1.5.1.14 created 1976, incorporated 1989), modified 2015
Pathway
ec00310  Lysine degradation
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
Orthology
K13609  delta1-piperideine-2-carboxylate reductase
Genes
EAS: Entas_0546
KPN: KPN_04791
KPU: KP1_0749
KPM: KPHS_06400
KPP: A79E_4358
KPH: KPNIH24_03290
KPZ: KPNIH27_03165
KPV: KPNIH29_03485
KPW: KPNIH30_03445
KPY: KPNIH31_04585
KPT: VK055_2646(dpkA)
KPE: KPK_4820
KPR: KPR_0871
KPJ: N559_4502
KPX: PMK1_02252(comC)
KPNU: LI86_23140
KPNK: BN49_4402
KVA: Kvar_4453
EAE: EAE_10410
EAR: CCG31912
CRO: ROD_48381(allD)
CAMA: F384_16275
EBF: D782_3914
SPE: Spro_1835
SPLY: Q5A_009085(lhpD)
SMAF: D781_1745
SMAR: SM39_1303
SERF: L085_19550
EPY: EpC_10400
EAM: EAMY_2586
EAY: EAM_2481
PAE: PA1252
PAEV: N297_1291
PAEI: N296_1291
PAEP: PA1S_19655
PAEM: U769_19495
PAEL: T223_20745
PAEG: AI22_14310
PAEC: M802_1288
PAEO: M801_1291
PPU: PP_3591(dpkA)
PPF: Pput_2181
PPT: PPS_3084
PPB: PPUBIRD1_2201(dpkA)
PPI: YSA_00209
PPX: T1E_2270
PPUH: B479_15340
PPUT: L483_18820
PPUN: PP4_22360
PPUD: DW66_3356
PMON: X969_14820
PMOT: X970_14465
PST: PSPTO_2359(allD)
PSB: Psyr_2143
PSYR: N018_10045
PFS: PFLU_2704
PFB: VO64_5794
PMAN: OU5_0213
PEN: PSEEN2669
PSTT: CH92_01000
PANR: A7J50_3234
PSIL: PMA3_13110
PIN: Ping_2116
GAI: IMCC3135_33065(lhpD)
HEL: HELO_3404(lhpD)
HAM: HALO3638
RME: Rmet_5095
BMA: BMAA1423
BMAE: DM78_4013
BMAI: DM57_08740
BMAF: DM51_5067
BMAZ: BM44_4895
BMAB: BM45_3797
BPS: BPSS0328
BPSE: BDL_3560
BPSM: BBQ_5871
BPSU: BBN_3724
BPSD: BBX_5398
BPK: BBK_5540
BPSH: DR55_5019
BPSA: BBU_5789
BPSO: X996_4788
BUT: X994_4288
BTQ: BTQ_5351
BTJ: BTJ_4003
BTZ: BTL_4827
BTD: BTI_4403
BTV: BTHA_5403
BTHE: BTN_4477
BTHM: BTRA_4743
BTHA: DR62_4591
BTHL: BG87_4808
BOK: DM82_4397
BOC: BG90_3679
BVE: AK36_4220
BCN: Bcen_4230
BCJ: BCAM1263
BCEN: DM39_3738
BCEW: DM40_4175
BCEO: I35_5111
BAM: Bamb_3547
BMU: Bmul_4451
BMK: DM80_3615
BMUL: NP80_4164
BCT: GEM_4480
BCED: DM42_3830
BDL: AK34_4217
BCON: NL30_06290
BUB: BW23_4935
BLAT: WK25_23220
BTEI: WS51_03990
BSEM: WJ12_26160
BPSL: WS57_07715
BMEC: WJ16_24790
BSTG: WT74_25105
BGO: BM43_7272
BUK: MYA_4528
BUL: BW21_3936
PLG: NCTC10937_02096(ybiC)
BPE: BP2521
BPC: BPTD_2478
BPER: BN118_1505
BPET: B1917_1338
BPEU: Q425_21020
BPA: BPP3508
BBR: BB2374
BPT: Bpet1261(mdh3)
PUT: PT7_1266
AJS: Ajs_3134
SME: SM_b20261
SMER: DU99_32065
SMD: Smed_3870
EAD: OV14_a1330(mdh)
ATU: Atu4676
AVI: Avi_7014(mdh)
RHT: NT26_0738
SHZ: shn_20835
BME: BMEII1005
BMEL: DK63_2251
BMEE: DK62_3156
BMF: BAB2_0960
BABO: DK55_2904
BABR: DO74_2219
BABT: DK49_2335
BABB: DK48_2893
BABU: DK53_2907
BABS: DK51_2393
BABC: DO78_2150
BMS: BRA0240
BSZ: DK67_2261
BOV: BOV_A0219
BCS: BCAN_B0242(mdh)
BCAR: DK60_3115
BCAS: DA85_11655
BMR: BMI_II236
BPV: DK65_2236
OAN: Oant_2899
OAH: DR92_3606
SNO: Snov_0154
PHL: KKY_1203
MMED: Mame_00343(comC)
KVU: EIO_3229
SMAZ: LH19_24995
SPHU: SPPYR_0556
STAX: MC45_12620
SSAN: NX02_14845
SSY: SLG_18160
ANH: A6F65_00113(comC)
PUB: SAR11_0966(yiaK)
MPH: MLP_36600
PLH: VT85_24400(comC)
 » show all
Taxonomy
Reference
1  [PMID:6801013]
  Authors
Payton CW, Chang YF.
  Title
delta1-piperideine-2-carboxylate reductase of Pseudomonas putida.
  Journal
J Bacteriol 149:864-71 (1982)
Reference
2  [PMID:15561717]
  Authors
Muramatsu H, Mihara H, Kakutani R, Yasuda M, Ueda M, Kurihara T, Esaki N
  Title
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline.
  Journal
J Biol Chem 280:5329-35 (2005)
DOI:10.1074/jbc.M411918200
  Sequence
Reference
3  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and  Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline  metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
[pae:PA1252]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.21
IUBMB Enzyme Nomenclature: 1.5.1.21
ExPASy - ENZYME nomenclature database: 1.5.1.21
BRENDA, the Enzyme Database: 1.5.1.21
CAS: 52037-88-4

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