KEGG   ENZYME: 1.5.1.24Help
Entry
EC 1.5.1.24                 Enzyme                                 

Name
N5-(carboxyethyl)ornithine synthase;
5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)
Reaction(IUBMB)
N5-(L-1-carboxyethyl)-L-ornithine + NADP+ + H2O = L-ornithine + pyruvate + NADPH + H+ [RN:R00666]
Reaction(KEGG)
Substrate
N5-(L-1-carboxyethyl)-L-ornithine [CPD:C04210];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-ornithine [CPD:C00077];
pyruvate [CPD:C00022];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
In the reverse direction, L-lysine can act instead of L-ornithine, but more slowly. Acts on the amino group. cf. EC 1.5.1.16, D-lysopine dehydrogenase.
History
EC 1.5.1.24 created 1990
Orthology
K00298  N5-(carboxyethyl)ornithine synthase
Genes
LLA: L64332(ceo)
LLK: LLKF_0282(ceo) LLKF_2279(ceo)
LLT: CVCAS_1204(ceo)
LLS: lilo_0584(ceo) lilo_1175(ceo)
LLD: P620_07035
LLX: NCDO2118_0284(ceo)
LLM: llmg_1237(ceo)
LLN: LLNZ_06370
LLW: kw2_1126
LLJ: LG36_1164(ceo)
LGR: LCGT_1205
LGV: LCGL_1225
CRN: CAR_c22550(ceo)
CTC: CTC_00375
CBO: CBO0515(ceo)
CBA: CLB_0555(ceo)
CBH: CLC_0588(ceo)
CBY: CLM_0606(ceo)
CBL: CLK_3726(ceo)
CBB: CLD_0234(ceo)
CBI: CLJ_B0591(ceo)
CBF: CLI_0595(ceo)
CBM: CBF_0563(ceo)
 » show all
Taxonomy
Reference
1  [PMID:2498334]
  Authors
Thompson J.
  Title
N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase from Streptococcus lactis. Purification and partial characterization.
  Journal
J Biol Chem 264:9592-601 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.24
IUBMB Enzyme Nomenclature: 1.5.1.24
ExPASy - ENZYME nomenclature database: 1.5.1.24
BRENDA, the Enzyme Database: 1.5.1.24
CAS: 129070-70-8

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