KEGG   ENZYME: 1.5.1.25Help
Entry
EC 1.5.1.25                 Enzyme                                 

Name
thiomorpholine-carboxylate dehydrogenase;
ketimine reductase;
ketimine-reducing enzyme
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
Reaction(IUBMB)
thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+ [RN:R04339 R04340]
Reaction(KEGG)
Substrate
thiomorpholine 3-carboxylate [CPD:C03901];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3,4-dehydro-thiomorpholine-3-carboxylate;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.
History
EC 1.5.1.25 created 1990
Orthology
K18258  thiomorpholine-carboxylate dehydrogenase
Genes
HSA: 1428(CRYM)
PTR: 742586(CRYM)
PPS: 100970861(CRYM)
GGO: 101125433(CRYM)
PON: 100454622(CRYM)
NLE: 100594088(CRYM)
MCC: 697588(CRYM)
MCF: 102132895(CRYM)
CSAB: 103229503(CRYM)
RRO: 104682086(CRYM)
RBB: 108514145(CRYM)
CJC: 100388738(CRYM)
SBQ: 101054393(CRYM)
MMU: 12971(Crym)
RNO: 117024(Crym)
CGE: 100771156(Crym)
NGI: 103742752(Crym)
HGL: 101706899(Crym)
CCAN: 109681372(Crym)
OCU: 100352494(CRYM)
TUP: 102468903(CRYM)
CFA: 479818(CRYM)
AML: 100467188(CRYM)
UMR: 103668887(CRYM) 103679843
ORO: 101380467(CRYM)
FCA: 101080756(CRYM)
PTG: 102963483(CRYM)
AJU: 106970514(CRYM)
BTA: 505167(CRYM)
BOM: 102273507 102287512(CRYM)
BIU: 109578830(CRYM)
PHD: 102326109(CRYM)
CHX: 100861024(CRYM)
OAS: 101102280(CRYM)
SSC: 100525333(CRYM)
CFR: 102507933(CRYM)
CDK: 105091116(CRYM)
BACU: 102999498(CRYM)
LVE: 103071882(CRYM)
OOR: 101269297(CRYM)
ECB: 100057895(CRYM)
EPZ: 103558982(CRYM)
EAI: 106841751(CRYM)
MYB: 102263573(CRYM)
MYD: 102759132(CRYM)
HAI: 109386574(CRYM)
RSS: 109458209(CRYM)
PALE: 102893293(CRYM)
LAV: 100668667(CRYM)
TMU: 101350705
MDO: 100019705(CRYM)
SHR: 100931649(CRYM)
OAA: 100087208(CRYM)
GGA: 427008(CRYM)
MGP: 100541881 104913518(CRYM)
CJO: 107306902 107321007(CRYM)
APLA: 101796429(CRYM)
ACYG: 106033492(CRYM)
TGU: 100229846(CRYM)
GFR: 102036801(CRYM)
FAB: 101819247(CRYM)
PHI: 102108632(CRYM)
PMAJ: 107211222(CRYM)
CCAE: 111936010(CRYM)
CCW: 104684868(CRYM)
FPG: 101911191(CRYM)
FCH: 102048264(CRYM)
CLV: 102090474(CRYM)
EGZ: 104135830(CRYM)
AAM: 106491377(CRYM)
ASN: 102368044(CRYM)
AMJ: 102562821(CRYM)
PSS: 102459235(CRYM)
CMY: 102942903(CRYM)
CPIC: 101934927(CRYM)
ACS: 100561928(crym)
PVT: 110082175(CRYM)
PBI: 103066829(CRYM)
GJA: 107123046(CRYM)
XLA: 100101313(crym.L) 447114
XTR: 100125176(crym)
NPR: 108794751(CRYM)
DRE: 791205(crym)
SANH: 107684776
SGH: 107569187
CCAR: 109054010(crym)
IPU: 100528988(crym)
AMEX: 103034376(crym)
TRU: 101080177(crym)
LCO: 104918063(crym)
NCC: 104958531 104961642(crym)
MZE: 101484163(crym)
OLA: 101169817(crym)
XMA: 102219012(crym)
PRET: 103481974(crym)
NFU: 107388174(crym)
KMR: 108237170(crym)
CSEM: 103382357(crym)
LCF: 108880772(crym)
SDU: 111220228(crym)
HCQ: 109516409(crym)
BPEC: 110159667(crym)
MALB: 109969179(crym)
SASA: 100286546(crym)
OTW: 112224477(crym)
ELS: 105031485(crym)
SFM: 108939939(crym)
LCM: 102367345(CRYM)
CMK: 103178740(crym)
DME: Dmel_CG4872(CG4872)
DSI: Dsimw501_GD17316(Dsim_GD17316)
MDE: 101899954
AAG: 5579138
TCA: 662385
DPA: 109545379
NVL: 108566671
CLEC: 106665164
CRG: 105347352
MYI: 110455669
OBI: 106870447
ADF: 107347081
HMG: 101237510
AQU: 100640786
LIH: L63ED372_00775(ala)
GBA: J421_0806
 » show all
Taxonomy
Reference
1  [PMID:3371353]
  Authors
Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D.
  Title
Purification and characterization of a ketimine-reducing enzyme.
  Journal
Eur J Biochem 173:689-94 (1988)
DOI:10.1111/j.1432-1033.1988.tb14053.x
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.25
IUBMB Enzyme Nomenclature: 1.5.1.25
ExPASy - ENZYME nomenclature database: 1.5.1.25
BRENDA, the Enzyme Database: 1.5.1.25
CAS: 115232-54-7

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