KEGG   ENZYME: 1.5.1.32Help
Entry
EC 1.5.1.32                 Enzyme                                 

Name
vomilenine reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
1,2-dihydrovomilenine:NADP+ oxidoreductase
Reaction(IUBMB)
1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+ [RN:R05878]
Reaction(KEGG)
Substrate
1,2-dihydrovomilenine [CPD:C11808];
NADP+ [CPD:C00006]
Product
vomilenine [CPD:C01761];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Forms part of the ajmaline biosynthesis pathway.
History
EC 1.5.1.32 created 2002
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:11937349]
  Authors
von Schumann G, Gao S, Stockigt J.
  Title
Vomilenine reductase--a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline.
  Journal
Bioorg Med Chem 10:1913-8 (2002)
DOI:10.1016/S0968-0896(01)00435-7
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.32
IUBMB Enzyme Nomenclature: 1.5.1.32
ExPASy - ENZYME nomenclature database: 1.5.1.32
BRENDA, the Enzyme Database: 1.5.1.32
CAS: 462127-03-3

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