KEGG   ENZYME: 1.5.1.33Help
Entry
EC 1.5.1.33                 Enzyme                                 

Name
pteridine reductase;
PTR1;
pteridine reductase 1
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ [RN:R01812]
Reaction(KEGG)
Substrate
5,6,7,8-tetrahydrobiopterin [CPD:C00272];
NADP+ [CPD:C00006]
Product
biopterin [CPD:C06313];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.
History
EC 1.5.1.33 created 1999 as EC 1.1.1.253, transferred 2003 to EC 1.5.1.33
Orthology
K03793  pteridine reductase
Genes
BFO: BRAFLDRAFT_106580(NRAS) BRAFLDRAFT_130700
EPA: 110237103
TBR: Tb927.8.2210
LMA: LMJF_23_0270(PTR1)
LIF: LINJ_23_0310(PTR1)
LDO: LDBPK_230310
LMI: LMXM_23_0270
LBZ: LBRM_23_0300(PTR1)
PLU: plu2798
PLUM: A4R40_13950
XFA: XF_1457
XFT: PD_0677(ptr1)
XCC: XCC3431(ptr1)
XCB: XC_0733
XCA: xcc-b100_0765(fabG1)
XCP: XCR_3772
XCV: XCV0748
XAX: XACM_0692(ptr1)
XAC: XAC0688(ptr1)
XCI: XCAW_03893(fabG)
XOO: XOO3932(ptr1)
XOM: XOO3709(XOO3709)
XOP: PXO_04308
XOR: XOC_0747
XAL: XALC_0833
XPH: XppCFBP6546_08140(XppCFBP6546P_08140)
SML: Smlt4030
SMT: Smal_3430
SMZ: SMD_3621
PSUW: WQ53_06825
PSD: DSC_00315
LEZ: GLE_3011
LEM: LEN_2023
DKO: I596_2416
PAR: Psyc_1369
PALI: A3K91_1557
PSYA: AOT82_624
MCT: MCR_0453
MCS: DR90_1454
MCAT: MC25239_00469(ycdF)
SAZ: Sama_1764
SLO: Shew_2034
SPL: Spea_2265
SHL: Shal_2019
SWP: swp_2460
SVO: SVI_2305
SPSW: Sps_01082
PAT: Patl_2501
MAQ: Maqu_3161
MHC: MARHY3101
MAD: HP15_2995
AMAL: I607_07410
AMAE: I876_07680
AMAO: I634_07800
AMAD: I636_08215
AMAI: I635_08145
AMAG: I533_07675
AMAC: MASE_07300
AAUS: EP12_08200
GPS: C427_2441
SALH: HMF8227_01346(ptr1)
FBL: Fbal_1844
CJA: CJA_0772
SDE: Sde_0726
MICC: AUP74_01286(fabG_2)
LPN: lpg2863
LPH: LPV_3220(phaB)
LPO: LPO_3167(phaB)
LPM: LP6_2892
LPF: lpl2775
LPP: lpp2921
LPC: LPC_3148(phaB)
LPA: lpa_04163
LPE: lp12_2852
LLO: LLO_0172(phaB)
LFA: LFA_3594
LHA: LHA_0209
LOK: Loa_02936
LCD: clem_14155(fabG_5)
LLG: 44548918_00092(fabG_1)
TMC: LMI_0151
MCA: MCA2986
CYQ: Q91_0095
TIG: THII_0394
TEE: Tel_14965
TGR: Tgr7_0328
TKM: TK90_0152
TVR: TVD_12885
ABO: ABO_2053
ADI: B5T_00970
APAC: S7S_14975
AXE: P40_04625
OCE: GU3_10140
SLIM: SCL_0170
SVA: SVA_0160
TBN: TBH_C2057
RMA: Rmag_0437
ENM: EBS_0539
CVI: CV_4132
LHK: LHK_00282
PSE: NH8B_0410
NEU: NE1165
NET: Neut_1504
TBD: Tbd_2701
MFA: Mfla_0229
MMB: Mmol_0291
MEH: M301_0284
MEP: MPQ_0259(fabG)
SLT: Slit_0168
GCA: Galf_0191
EBA: ebA3368
DSU: Dsui_0694
AZO: azo0486
AZA: AZKH_4339
AOA: dqs_0497
TCL: Tchl_1517
ADE: Adeh_3477
MXA: MXAN_6879
CCX: COCOR_07451(fabG13)
SCL: sce8666
AFR: AFE_0129
ACU: Atc_2772
RCA: Rcas_3869
PIR: VN12_23180(fabG_8)
PLH: VT85_14980(fabG_2)
TTF: THTE_1784
GES: VT84_02760(lvr_1) VT84_23615(ycdF_2)
IPA: Isop_0230
SACI: Sinac_5624
PBOR: BSF38_03993(fabG_6)
PBU: L21SP3_02191(fabG_2)
GAU: GAU_1989
GBA: J421_3591
CABY: Cabys_722
 » show all
Taxonomy
Reference
1  [PMID:9153248]
  Authors
Nare B, Hardy LW, Beverley SM.
  Title
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
  Journal
J Biol Chem 272:13883-91 (1997)
DOI:10.1074/jbc.272.21.13883
  Sequence
Reference
2  [PMID:11373620]
  Authors
Gourley DG, Schuttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN.
  Title
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
  Journal
Nat Struct Biol 8:521-5 (2001)
DOI:10.1038/88584
  Sequence
Reference
3  [PMID:10800597]
  Authors
Fitzpatrick PF.
  Title
The aromatic amino acid hydroxylases.
  Journal
Adv Enzymol Relat Areas Mol Biol 74:235-94 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.33
IUBMB Enzyme Nomenclature: 1.5.1.33
ExPASy - ENZYME nomenclature database: 1.5.1.33
BRENDA, the Enzyme Database: 1.5.1.33
CAS: 131384-61-7

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