KEGG   ENZYME: 1.5.1.36Help
Entry
EC 1.5.1.36                 Enzyme                                 

Name
flavin reductase (NADH);
NADH-dependent flavin reductase;
flavin:NADH oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
flavin:NAD+ oxidoreductase
Reaction(IUBMB)
reduced flavin + NAD+ = flavin + NADH + H+ [RN:R09662]
Reaction(KEGG)
Substrate
reduced flavin [CPD:C19790];
NAD+ [CPD:C00003]
Product
flavin [CPD:C00176];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH.
History
EC 1.5.1.36 created 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K00484  flavin reductase (NADH)
K21297  flavin reductase (NADH)
K22393  flavin reductase (NADH) subunit 1
K22394  flavin reductase (NADH) subunit 2
Genes
EOJ: ECO26_5548(hpaC)
EOI: ECO111_5205(hpaC)
EOH: ECO103_5127(hpaC)
ECOO: ECRM13514_5599
ECOH: ECRM13516_5312
ECX: EcHS_A4575(hpaC)
ECY: ECSE_4620
ECR: ECIAI1_4566(hpaC)
EUM: ECUMN_4965(hpaC)
ECL: EcolC_3711
EBR: ECB_04221(hpaC)
EBD: ECBD_3675
EKF: KO11_23360(hpaC)
ELW: ECW_m4704(hpaC)
ELL: WFL_22915(hpaC)
EBL: ECD_04221(hpaC)
EBE: B21_04187(ybl221)
EFE: EFER_3071(hpaC)
STY: STY1130(hpaC)
STT: t1821(hpaC)
STM: STM1098(hpaC)
SEO: STM14_1246(hpaC)
SEY: SL1344_1037(hpaC)
SEJ: STMUK_1067(hpaC)
SEB: STM474_1090(hpaC)
SEF: UMN798_1139(hpaC)
SETU: STU288_01820(hpaC)
SETC: CFSAN001921_11685(hpaC)
SENR: STMDT2_10341(hpaC)
SEND: DT104_10801(hpaC)
SENI: CY43_05610(hpaC)
SEEN: SE451236_11340(hpaC)
SPT: SPA1752(hpaC)
SEK: SSPA1628
SEI: SPC_2652(hpaC)
SEC: SCH_1048(hpaC)
SEH: SeHA_C1208(hpaC)
SHB: SU5_01729
SENH: CFSAN002069_03530(hpaC)
SEEH: SEEH1578_14715(hpaC)
SEE: SNSL254_A1193(hpaC)
SEW: SeSA_A1162(hpaC)
SEA: SeAg_B1057(hpaC)
SENS: Q786_04905(hpaC)
SED: SeD_A1173(hpaC)
SEG: SG0987(hpaC)
SEL: SPUL_1959(hpaC)
SEGA: SPUCDC_1945(hpaC)
SET: SEN0962(hpaC)
SENA: AU38_04965(hpaC)
SENO: AU37_04955(hpaC)
SENV: AU39_04955(hpaC)
SENQ: AU40_05570(hpaC)
SENL: IY59_05055(hpaC)
SENJ: CFSAN001992_06155(hpaC)
SEEC: CFSAN002050_11885(hpaC)
SEEB: SEEB0189_014080(hpaC)
SEEP: I137_08905(hpaC)
SENB: BN855_10530(hpaC)
SENE: IA1_05405(hpaC)
SENC: SEET0819_12150(hpaC)
SBG: SBG_0944(hpaC)
SBZ: A464_1037
SFL: SF4373(hpaC)
SFX: S4643(hpaC)
SFV: SFV_4374(hpaC)
SFE: SFxv_4767
SFN: SFy_6274
SFS: SFyv_6345
SFT: NCTC1_04749(hpaC)
SSN: SSON_4488(hpaC)
SBO: SBO_4403(hpaC)
SBC: SbBS512_E4881(hpaC)
SHQ: A0259_03500(hpaC)
ENC: ECL_00749(hpaC)
ECLO: ENC_44630
EEC: EcWSU1_00546(hpaC)
ECLE: ECNIH2_03895(hpaC)
ECLN: ECNIH4_19905(hpaC)
ECLI: ECNIH5_03020(hpaC)
ECLX: LI66_03015(hpaC)
ECLY: LI62_03485(hpaC)
ECLZ: LI64_02990(hpaC)
EHM: AB284_21990(hpaC)
ECLA: ECNIH3_03020(hpaC)
ECLC: ECR091_03000(hpaC)
EAU: DI57_15625(hpaC)
ECAN: CWI88_19300(hpaC)
ECLS: LI67_003950(hpaC)
ENX: NI40_002860(hpaC)
KPN: KPN_04779(hpaC)
KPU: KP1_0733(hpaC)
KPP: A79E_4373
KPK: A593_13950(hpaC)
KPH: KPNIH24_03220(hpaC)
KPZ: KPNIH27_03095(hpaC)
KPV: KPNIH29_03410(hpaC)
KPW: KPNIH30_03370(hpaC)
KPY: KPNIH31_04695(hpaC)
KPG: KPNIH32_03375(hpaC)
KPC: KPNIH10_03200(hpaC)
KPQ: KPR0928_03210(hpaC)
KPT: VK055_2660(hpaC)
KPE: KPK_4841(hpaC)
KPO: KPN2242_02030(hpaC)
KPR: KPR_0856(hpaC)
KPJ: N559_4517
KPI: D364_24350(hpaC)
KPX: PMK1_02238(hpaC)
KPB: FH42_20415(hpaC)
KPNE: KU54_023375(hpaC)
KPNU: LI86_23215(hpaC)
KPNK: BN49_4415(hpaC)
KVA: Kvar_4473
KOX: KOX_10010(hpaC)
KOE: A225_0704
KOY: J415_27725(hpaC)
KOM: HR38_08735(hpaC)
KOK: KONIH1_03735(hpaC)
KOC: AB185_32455(hpaC)
EAE: EAE_10310(hpaC)
EAR: CCG31933
KQV: B8P98_24245(hpaC)
CBRA: A6J81_18500(hpaC)
EBT: EBL_c34050(hpaC)
ROR: RORB6_15570(hpaC)
RON: TE10_05450(hpaC)
PGE: LG71_25565(hpaC)
KLE: AO703_02885(hpaC)
KGO: CEW81_19470(hpaC)
LAX: APT61_19370(hpaC)
LEI: C2U54_07960(hpaC)
LEH: C3F35_08745(hpaC)
LNI: CWR52_09250(hpaC)
EBF: D782_3928
YPE: YPO1770(hpaC)
YPK: y2538
YPH: YPC_2511(hpaC)
YPA: YPA_1142
YPN: YPN_2353
YPM: YP_1623(hpaC)
YPG: YpAngola_A1639(hpaC)
YPZ: YPZ3_1948(hpaC)
YPD: YPD4_1568(hpaC)
YPX: YPD8_1986(hpaC)
YPW: CH59_3397(hpaC)
YPJ: CH55_907(hpaC)
YPV: BZ15_1779(hpaC)
YPL: CH46_3353(hpaC)
YPS: YPTB1646(hpaC)
YPO: BZ17_856(hpaC)
YPI: YpsIP31758_2356(hpaC)
YPY: YPK_2452
YPB: YPTS_1770
YPQ: DJ40_577(hpaC)
YPU: BZ21_996(hpaC)
YPR: BZ20_329(hpaC)
YPC: BZ23_1274(hpaC)
YPF: BZ19_1073(hpaC)
SPE: Spro_0635
SRL: SOD_c05030(hpaC)
SRY: M621_02655(hpaC)
SPLY: Q5A_002645(hpaC)
SMAF: D781_0579
SMW: SMWW4_v1c05910(rutF)
SMAR: SM39_4968(hpaC)
SMAC: SMDB11_4711(hpaC)
SLQ: M495_02520(hpaC)
SERF: L085_01145
SERM: CLM71_02805(hpaC)
SFO: Z042_16845(hpaC)
PLU: plu0974(hpaC)
PLUM: A4R40_04865(hpaC)
PAY: PAU_00909(hpaC)
PTT: VY86_13815(hpaC)
PMR: PMI0246(hpaC)
PMIB: BB2000_0397(hpaC)
PVL: AOB99_03995(hpaC)
PVG: CRN77_18180(hpaC)
XBO: XBJ1_3599(ycdH)
XBV: XBW1_1453(hpaC)
XNE: XNC1_0810(ycdH)
XNM: XNC2_0796(ycdH)
XDO: XDD1_1012(hpaC)
PSI: S70_06525
PSX: DR96_1963(hpaC)
PRG: RB151_008020(hpaC)
PALA: CO695_00800(hpaC)
PHEI: NCTC12003_00815(hpaC)
MMK: MU9_1190
HAV: AT03_16965(hpaC)
OPO: DSM2777_08260(hpaC)
HDU: HD_0987(hpaC)
PMU: PM1522
PMV: PMCN06_1789(hpaC)
PMP: Pmu_17890(hpaC)
PMUL: DR93_371(hpaC)
PDAG: 4362423_01844(hpaC)
MHT: D648_19650(hpaC)
MHQ: D650_6580(hpaC)
MHAT: B824_19600(hpaC)
MHX: MHH_c28120(hpaC)
MHAE: F382_04765(hpaC)
MHAM: J450_03765(hpaC)
MHAO: J451_05010(hpaC)
MHAL: N220_10895(hpaC)
MHAQ: WC39_03320(hpaC)
MHAY: VK67_03320(hpaC)
MVR: X781_6410
MVE: X875_4960
APL: APL_1349(hpaC)
APJ: APJL_1367(hpaC)
APA: APP7_1401(hpaC)
AEU: ACEE_11280(hpaC)
BTO: WQG_18690
BTRE: F542_3890
BTRH: F543_4540
BTRA: F544_18490
VVY: VV1574
VNI: VIBNI_B1951(hpaC)
VMI: AL543_16395(hpaC)
PAE: PA4092(hpaC)
PAEV: N297_4222(hpaC)
PAEI: N296_4222(hpaC)
PAU: PA14_10990(hpaC)
PAP: PSPA7_1006(hpaC)
PAG: PLES_08841(hpaC)
PAF: PAM18_0848(hpaC)
PNC: NCGM2_5293(hpaC)
PAEB: NCGM1900_0868(hpaC)
PAEP: PA1S_04370
PAEM: U769_04380
PAEL: T223_04320
PAEU: BN889_04542(hpaC)
PAEG: AI22_29245(hpaC)
PAEC: M802_4220(hpaC)
PAEO: M801_4088(hpaC)
PCQ: PcP3B5_30280(hpaC)
PFL: PFL_3357(hpaC)
PPRC: PFLCHA0_c33870(hpaC)
PPRO: PPC_3381(hpaC)
PSEM: TO66_17315
PSOS: POS17_3334(hpaC)
PSIL: PMA3_18105
CJA: CJA_1958
NME: NMB1842
NMP: NMBB_2105
NMH: NMBH4476_1786(hpaC)
NMD: NMBG2136_0375(hpaC)
NMM: NMBM01240149_0343(hpaC)
NMS: NMBM01240355_1776(hpaC)
NMQ: NMBM04240196_1783(hpaC)
NMZ: NMBNZ0533_0480(hpaC)
NMA: NMA0614
NMW: NMAA_0302
NMC: NMC0375
NMN: NMCC_0380
NMT: NMV_2032
NMI: NMO_0320
NGO: NGO0059
NGK: NGK_0083
NLA: NLA_17890
NWE: SAMEA3174300_1574(hpaC)
NSI: A6J88_13285(hpaC)
NMJ: NM96_07675(hpaC)
KKI: KKKWG1_0413(hpaC)
BTE: BTH_II0316(hpaC)
BTQ: BTQ_3610(hpaC)
BTJ: BTJ_4646(hpaC)
BTZ: BTL_5434(hpaC)
BTV: BTHA_4769(hpaC)
BTHE: BTN_5104(hpaC)
BTHM: BTRA_5373(hpaC)
BTHA: DR62_5234
BTHL: BG87_5440(hpaC)
BOK: DM82_6338(hpaC)
BOC: BG90_4336(hpaC)
BCJ: BCAM0638
BCEN: DM39_4519(hpaC) DM39_4923
BCEW: DM40_5612
BCEO: I35_4534 I35_5997(hpaC)
BAM: Bamb_5345
BMK: DM80_4251 DM80_4266(hpaC)
BMUL: NP80_3634(hpaC) NP80_3647
BCED: DM42_4452(hpaC)
BCON: NL30_22660
BLAT: WK25_18270
BSEM: WJ12_23160
BMEC: WJ16_22180
BGP: BGL_2c23400(hpaC)
BGU: KS03_3551(hpaC) KS03_4181
BGO: BM43_5956
BXE: Bxe_B2309
BXB: DR64_4641(hpaC)
BFN: OI25_3713(hpaC)
PARB: CJU94_31905(hpaC)
PHS: C2L64_07300(hpaC) C2L64_36225(hpaC)
PTER: C2L65_07035(hpaC) C2L65_31435(hpaC)
PGP: CUJ91_29455(hpaC)
PSPU: NA29_23280
PLG: NCTC10937_03008(hpaC)
HYF: DTO96_101741(hpaC)
DAR: Daro_0903
AZO: azo1943(hpaC)
MXA: MXAN_4827
CCX: COCOR_03296(ycdH)
BJA: blr7290(hpaC)
RSP: RSP_3957
MMI: MMAR_3634
NFA: NFA_28410
NFR: ERS450000_01248(hpaC)
RHA: RHA1_ro02847(hpaC)
ROP: ROP_25720(hpaC)
SBH: SBI_09695
SHY: SHJG_8629
SDV: BN159_2477(pyr9)
SLD: T261_7912
SRW: TUE45_00621(rbmH_1) TUE45_06418(rbmH_2)
SEN: SACE_4928
AOI: AORI_4210(hpaC) AORI_5335
ASE: ACPL_6145(ntaB)
TTH: TT_C0595
TTJ: TTHA0961
TAQ: TO73_1001
MRB: Mrub_1331
 » show all
Taxonomy
Reference
1  [PMID:10633095]
  Authors
Galan B, Diaz E, Prieto MA, Garcia JL
  Title
Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily.
  Journal
J Bacteriol 182:627-36 (2000)
DOI:10.1128/JB.182.3.627-636.2000
  Sequence
[elw:ECW_m4704]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.36
IUBMB Enzyme Nomenclature: 1.5.1.36
ExPASy - ENZYME nomenclature database: 1.5.1.36
BRENDA, the Enzyme Database: 1.5.1.36

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