KEGG   ENZYME: 1.5.1.39Help
Entry
EC 1.5.1.39                 Enzyme                                 

Name
FMN reductase [NAD(P)H];
FRG
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
FMNH2:NAD(P)+ oxidoreductase
Reaction(IUBMB)
FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+ [RN:R05705 R05706]
Reaction(KEGG)
Substrate
FMNH2 [CPD:C01847];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
FMN [CPD:C00061];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FMN. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 1.5.1.42, FMN reductase (NADH) and EC 1.5.1.38, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes [1]. Also reduces riboflavin and FAD, but more slowly.
History
EC 1.5.1.39 created 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K19286  FMN reductase [NAD(P)H]
Genes
GQU: AWC35_15390
EBT: EBL_c27760
LAX: APT61_15525
LEI: C2U54_11965
LEH: C3F35_04505
SMAF: D781_3978
SRZ: AXX16_1164
SERM: CLM71_20450
ECA: ECA0351
PATR: EV46_01875
PATO: GZ59_03810
PCT: PC1_0338
PEC: W5S_0391
ETA: ETA_14360
EPY: EpC_15110
EGE: EM595_1786(nfrA2)
PAM: PANA_4101(ycnD)
PLF: PANA5342_p10256(nfsA)
PAJ: PAJ_p0190(ycnD)
PAQ: PAGR_p187
PVA: Pvag_pPag30453(nfsA)
PSTW: DSJ_26140
PAY: PAU_03550(nfsA)
CVI: CV_3500(nfsA)
PSE: NH8B_0873(nfsA)
BHZ: ACR54_01072(nfrA2)
ARC: ABLL_0970
SDL: Sdel_1072
SMUL: SMUL_3050
SHAL: SHALO_2816
SULJ: SJPD1_2729
VGO: GJW-30_1_00134(nfrA2)
BSU: BSU03860(ycnD)
BSR: I33_0443
BSL: A7A1_3092
BSH: BSU6051_03860(ycnD)
BSUT: BSUB_00437(ycnD)
BSUL: BSUA_00437(ycnD)
BSUS: Q433_02300
BSS: BSUW23_01995(ycnD)
BST: GYO_0602
BSO: BSNT_06728(ycnD)
BSQ: B657_03860(ycnD)
BSX: C663_0379(ycnD)
BLI: BL01854(nfrA2)
BLD: BLi00470(nfrA1)
BLH: BaLi_c04910(ycnD)
BAY: RBAM_004110(ycnD)
BAQ: BACAU_0347(ycnD)
BYA: BANAU_0347(ycnD)
BAMP: B938_01820
BAML: BAM5036_0370(nfrAB)
BAMA: RBAU_0384(nfrAB)
BAMN: BASU_0369(nfrAB)
BAMB: BAPNAU_0352(ycnD)
BAMT: AJ82_02265
BAMY: V529_03720(ycnD)
BMP: NG74_00388(nfrA2)
BAO: BAMF_0354(ycnD)
BAZ: BAMTA208_01795(ycnD)
BQL: LL3_00369(ycnD)
BXH: BAXH7_00372(ycnD)
BQY: MUS_0374(nfrA1)
BAMI: KSO_017635
BAMC: U471_03760
BAMF: U722_02085
BHA: BH2953
BMQ: BMQ_3033
BMD: BMD_3058
BMH: BMWSH_2145(ycnD)
BMEG: BG04_5560(nfrA2)
BJS: MY9_0402
BACP: SB24_07760
BACB: OY17_04705
BACY: QF06_00900
BACL: BS34A_04440(ycnD)
BALM: BsLM_0407
BEO: BEH_12430
BGY: BGLY_0483(nfrA2)
PLV: ERIC2_c22420(nfrA)
PSAB: PSAB_09310
PRI: PRIO_5617(nfrA2)
PSWU: SY83_09875
LMM: MI1_07670
LMK: LMES_1537
LKI: LKI_07275
CAC: CA_C0718
CAE: SMB_G0733(nfrA2)
CAY: CEA_G0729
CBE: Cbei_2778
CBZ: Cbs_2778
CBEI: LF65_02693
CSR: Cspa_c24470(nfrA2)
CSB: CLSA_c18180(nfrA)
CST: CLOST_2291(ycnD)
AWO: Awo_c31780(ycnD)
PUF: UFO1_1217
MBH: MMB_0518
MBI: Mbov_0557(nfsA)
LBA: Lebu_0572
SMF: Smon_1230
BOA: Bovatus_01450(nfrA2_2)
ACJ: ACAM_0063
 » show all
Taxonomy
Reference
1  [PMID:6981058]
  Authors
Watanabe H, Hastings JW
  Title
Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase.
  Journal
Mol Cell Biochem 44:181-7 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.39
IUBMB Enzyme Nomenclature: 1.5.1.39
ExPASy - ENZYME nomenclature database: 1.5.1.39
BRENDA, the Enzyme Database: 1.5.1.39

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