KEGG   ENZYME: 1.5.1.44Help
Entry
EC 1.5.1.44                 Enzyme                                 

Name
festuclavine dehydrogenase;
FgaFS;
festuclavine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
festuclavine:NAD+ oxidoreductase
Reaction(IUBMB)
festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ [RN:R10163]
Reaction(KEGG)
Substrate
festuclavine [CPD:C20408];
NAD+ [CPD:C00003]
Product
6,8-dimethyl-6,7-didehydroergoline [CPD:C20409];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.
History
EC 1.5.1.44 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19183  festuclavine dehydrogenase
Genes
MAJ: MAA_06737
GLZ: GLAREA_05927
AFM: AFUA_2G17970
PBL: PAAG_05656
PBN: PADG_07739
Taxonomy
Reference
1  [PMID:20526482]
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.44
IUBMB Enzyme Nomenclature: 1.5.1.44
ExPASy - ENZYME nomenclature database: 1.5.1.44
BRENDA, the Enzyme Database: 1.5.1.44

DBGET integrated database retrieval system