KEGG   ENZYME: 1.5.1.6Help
Entry
EC 1.5.1.6                  Enzyme                                 

Name
formyltetrahydrofolate dehydrogenase;
10-formyl tetrahydrofolate:NADP oxidoreductase;
10-formyl-H2PtGlu:NADP oxidoreductase ;
10-formyl-H4folate dehydrogenase;
N10-formyltetrahydrofolate dehydrogenase ;
10-formyltetrahydrofolate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
10-formyltetrahydrofolate:NADP+ oxidoreductase
Reaction(IUBMB)
10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Reaction(KEGG)
Substrate
10-formyltetrahydrofolate [CPD:C00234];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
tetrahydrofolate [CPD:C00101];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.6 created 1972
Pathway
ec00670  One carbon pool by folate
Orthology
K00289  formyltetrahydrofolate dehydrogenase
Genes
HSA: 10840(ALDH1L1) 160428(ALDH1L2)
PTR: 452195(ALDH1L2) 460655(ALDH1L1)
PPS: 100978685(ALDH1L2) 100989341(ALDH1L1)
GGO: 101134299(ALDH1L1) 101139377(ALDH1L2)
PON: 100172380(ALDH1L1) 100459691(ALDH1L2)
NLE: 100587670(ALDH1L1) 100604236(ALDH1L2)
MCC: 701242(ALDH1L2) 716977(ALDH1L1)
MCF: 102115759(ALDH1L2) 102146254(ALDH1L1)
CSAB: 103228129(ALDH1L1) 103239007(ALDH1L2)
RRO: 104657483(ALDH1L2) 104675907(ALDH1L1)
RBB: 108528191(ALDH1L1) 108544280(ALDH1L2)
CJC: 100391281(ALDH1L1) 100403455(ALDH1L2)
SBQ: 101028391(ALDH1L2) 101052460(ALDH1L1)
MMU: 107747(Aldh1l1) 216188(Aldh1l2)
RNO: 299699(Aldh1l2) 64392(Aldh1l1)
CGE: 100762089(Aldh1l1) 100772371(Aldh1l2)
NGI: 103730367(Aldh1l1) 103742132(Aldh1l2)
HGL: 101697075(Aldh1l2) 101709289(Aldh1l1)
CCAN: 109681401(Aldh1l1) 109685514(Aldh1l2)
OCU: 100355778(ALDH1L2) 100356705(ALDH1L1)
TUP: 102499911(ALDH1L1) 102502729(ALDH1L2)
CFA: 474534(ALDH1L2) 476506
AML: 100476798(ALDH1L2)
UMR: 103669466(ALDH1L1) 103676565(ALDH1L2)
ORO: 101369691(ALDH1L1) 101380649(ALDH1L2)
FCA: 101088592(ALDH1L2) 101091432(ALDH1L1)
PTG: 102969433(ALDH1L2) 102971961(ALDH1L1)
AJU: 106968242(ALDH1L1) 106971881(ALDH1L2) 106985431
BTA: 505677(ALDH1L1) 516864(ALDH1L2)
BOM: 102265689 102269375(ALDH1L2) 102284810 102285357(ALDH1L1)
BIU: 109556620(ALDH1L1) 109559467(ALDH1L2)
PHD: 102339562(ALDH1L1) 102342576(ALDH1L2)
CHX: 102179144(ALDH1L1) 102189931(ALDH1L2)
OAS: 100913154(ALDH1L1) 101114182(ALDH1L2)
SSC: 100151976(ALDH1L2) 100622210(ALDH1L1)
CFR: 102512961(ALDH1L1) 102521632(ALDH1L2)
CDK: 105102962(ALDH1L2) 105104512(ALDH1L1)
BACU: 103005570(ALDH1L2) 103015395(ALDH1L1)
LVE: 103079904(ALDH1L2) 103083157(ALDH1L1)
OOR: 101286106(ALDH1L2) 101287203(ALDH1L1)
ECB: 100053705(ALDH1L2) 100061108(ALDH1L1)
EPZ: 103552696(ALDH1L2) 103567591
EAI: 106834458(ALDH1L1) 106846797(ALDH1L2)
MYB: 102246127(ALDH1L1) 102256559(ALDH1L2)
MYD: 102751421(ALDH1L1) 102763705(ALDH1L2)
HAI: 109377662(ALDH1L1) 109387752(ALDH1L2)
PALE: 102886245(ALDH1L2) 102893157(ALDH1L1)
LAV: 100667848(ALDH1L2) 100671746(ALDH1L1)
MDO: 100022528(ALDH1L2) 100026594(ALDH1L1)
SHR: 100918967(ALDH1L1) 100922488(ALDH1L2)
OAA: 100074128(ALDH1L2)
GGA: 418078(ALDH1L2)
MGP: 100545356(ALDH1L2)
CJO: 107314831(ALDH1L2)
APLA: 101803074(ALDH1L2)
ACYG: 106035909(ALDH1L2)
TGU: 100230131(ALDH1L2)
GFR: 102034252(ALDH1L2)
FAB: 101806345(ALDH1L2)
PHI: 102110155(ALDH1L2)
PMAJ: 107205083(ALDH1L2)
CCAE: 111931314(ALDH1L2)
CCW: 104696244(ALDH1L2)
FPG: 101912914(ALDH1L2)
FCH: 102059837(ALDH1L2)
CLV: 102096623(ALDH1L2)
EGZ: 104132735(ALDH1L2)
AAM: 106488260(ALDH1L2)
ASN: 102384520(ALDH1L2)
AMJ: 102558655(ALDH1L2)
PSS: 102444892(ALDH1L2)
CMY: 102943513(ALDH1L2)
CPIC: 101938032(ALDH1L2)
ACS: 100552265(aldh1l2)
PVT: 110084777(ALDH1L2)
PBI: 103068063(ALDH1L2)
GJA: 107124197(ALDH1L2)
XLA: 108711033 108713198 444321(aldh1l1.L)
XTR: 100127737(aldh1l2) 496436(aldh1l1)
DRE: 100333269(aldh1l2) 100526683(aldh1l1)
IPU: 108272091 108280121(aldh1l2)
AMEX: 103022276 103024881(aldh1l2)
TRU: 101063025 101078185(aldh1l2)
LCO: 104923764(aldh1l2) 104936356
OLA: 101167504(aldh1l2) 101174660
KMR: 108228235 108228428(aldh1l2)
CSEM: 103382426(aldh1l2) 103386628
LCF: 108877470 108897497(aldh1l2)
SDU: 111221548 111224720(aldh1l2)
MALB: 109960958(aldh1l2) 109970592
SFM: 108918573 108921000(aldh1l2)
LCM: 102358231(ALDH1L1) 102358739(ALDH1L2)
CMK: 103176681(aldh1l1) 103189341(aldh1l2)
CIN: 100184767(aldh1l2)
SPU: 579576(ALDH1L2)
APLC: 110988231
SKO: 100377034
DME: Dmel_CG8665(CG8665)
DPE: 6596524
DSI: Dsimw501_GD24321(Dsim_GD24321)
DWI: 6646785
MDE: 101890653
AAG: 110673980
AME: 551401
BIM: 100746301
BTER: 100649608
SOC: 105206141
AEC: 105153649
ACEP: 105622759
PBAR: 105424800
HST: 105187366
DQU: 106749188
CFO: 105248128
LHU: 105679818
PGC: 109861483
PCF: 106785278
NVI: 100119020
MDL: 103568156
TCA: 658435
DPA: 109543725
NVL: 108569633
BMOR: 101747054
PMAC: 106709931
HAW: 110370815
API: 100164524
DNX: 107173475
ZNE: 110839967
FCD: 110852894
TUT: 107359586
CEL: CELE_F36H1.6(alh-3)
CBR: CBG05984(Cbr-alh-3)
CRG: 105347685
MYI: 110441897
OBI: 106875996
EPA: 110242486
ADF: 107340102
 » show all
Taxonomy
Reference
1  [PMID:4384443]
  Authors
Kutzbach C, Stokstad EL.
  Title
Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver.
  Journal
Biochem Biophys Res Commun 30:111-7 (1968)
DOI:10.1016/0006-291X(68)90456-7
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.6
IUBMB Enzyme Nomenclature: 1.5.1.6
ExPASy - ENZYME nomenclature database: 1.5.1.6
BRENDA, the Enzyme Database: 1.5.1.6
CAS: 37256-25-0

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