KEGG   ENZYME: 1.5.3.12Help
Entry
EC 1.5.3.12                 Enzyme                                 

Name
dihydrobenzophenanthridine oxidase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
dihydrobenzophenanthridine:oxygen oxidoreductase
Reaction(IUBMB)
(1) dihydrosanguinarine + O2 = sanguinarine + H2O2 [RN:R04703];
(2) dihydrochelirubine + O2 = chelirubine + H2O2 [RN:R04706];
(3) dihydromacarpine + O2 = macarpine + H2O2 [RN:R04768]
Reaction(KEGG)
Substrate
dihydrosanguinarine [CPD:C05191];
O2 [CPD:C00007];
dihydrochelirubine [CPD:C05194];
dihydromacarpine [CPD:C05316]
Product
sanguinarine [CPD:C06162];
H2O2 [CPD:C00027];
chelirubine [CPD:C06327];
macarpine [CPD:C06165]
Comment
A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids
History
EC 1.5.3.12 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:24241413]
  Authors
Schumacher HM, Zenk MH
  Title
Partial purification and characterization of dihydrobenzophenanthridine oxidase from Eschscholtzia californica cell suspension cultures.
  Journal
Plant Cell Rep 7:43-6 (1988)
DOI:10.1007/BF00272975
Reference
2  [PMID:1444440]
  Authors
Arakawa H, Clark WG, Psenak M, Coscia CJ.
  Title
Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures.
  Journal
Arch Biochem Biophys 299:1-7 (1992)
DOI:10.1016/0003-9861(92)90236-P
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.12
IUBMB Enzyme Nomenclature: 1.5.3.12
ExPASy - ENZYME nomenclature database: 1.5.3.12
BRENDA, the Enzyme Database: 1.5.3.12
CAS: 114051-83-1

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