KEGG   ENZYME: 1.5.3.16Help
Entry
EC 1.5.3.16                 Enzyme                                 

Name
spermine oxidase;
PAOh1/SMO;
PAOh1 (ambiguous);
AtPAO1;
AtPAO4;
SMO;
mSMO;
SMO(PAOh1);
SMO/PAOh1;
SMO5;
mSMOmu
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
spermidine:oxygen oxidoreductase (spermidine-forming)
Reaction(IUBMB)
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027]
Comment
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase).
History
EC 1.5.3.16 created 2009
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
Orthology
K12259  spermine oxidase
K13366  polyamine oxidase
Genes
HSA: 54498(SMOX)
PTR: 458074(SMOX)
PPS: 100983105(SMOX)
GGO: 101133425(SMOX)
PON: 100462330(SMOX)
NLE: 100586685(SMOX)
MCC: 718761(SMOX)
MCF: 101867246(SMOX)
CSAB: 103247041(SMOX)
RRO: 104674589(SMOX)
RBB: 108533448(SMOX)
CJC: 100397119(SMOX)
SBQ: 101038093(SMOX)
MMU: 228608(Smox)
RNO: 308652(Smox)
CGE: 100763379(Smox)
NGI: 103736403(Smox)
HGL: 101707899(Smox)
CCAN: 109701346(Smox)
OCU: 100347645(SMOX)
TUP: 102477539(SMOX)
CFA: 485787(SMOX)
AML: 100480545(SMOX)
UMR: 103674402(SMOX)
ORO: 101369107(SMOX)
FCA: 101084867(SMOX)
PTG: 102953447(SMOX)
AJU: 106980151(SMOX)
BTA: 527211(SMOX)
BOM: 102278225(SMOX)
BIU: 109567182(SMOX)
PHD: 102342141(SMOX)
CHX: 102176898(SMOX)
OAS: 101118975(SMOX)
SSC: 100152781(SMOX)
CFR: 102519491(SMOX)
CDK: 105096013(SMOX)
BACU: 103015742(SMOX)
LVE: 103072563(SMOX)
OOR: 101282884(SMOX)
ECB: 100052311(SMOX)
EPZ: 103541202(SMOX)
EAI: 106847685(SMOX)
MYB: 102248159(SMOX)
MYD: 102768889(SMOX)
HAI: 109383858(SMOX)
RSS: 109440697 109448463(SMOX)
PALE: 102891646(SMOX)
LAV: 100671284(SMOX)
TMU: 101347613
MDO: 100030883(SMOX)
SHR: 100917297 100926267(SMOX)
OAA: 100085736(SMOX)
GGA: 422934(SMOX)
MGP: 100540689(SMOX)
CJO: 107314119(SMOX)
APLA: 101789809(SMOX)
ACYG: 106036754(SMOX)
TGU: 100232049(SMOX)
GFR: 102037069(SMOX)
FAB: 101815717(SMOX)
PHI: 102104257(SMOX)
PMAJ: 107203206(SMOX)
CCW: 104690827(SMOX)
FPG: 101911959(SMOX)
FCH: 102050731(SMOX)
CLV: 102085808(SMOX)
EGZ: 104124541(SMOX)
AAM: 106489575(SMOX)
ASN: 102381757(SMOX)
AMJ: 102561876(SMOX)
PSS: 102458431(SMOX)
CMY: 102934652(SMOX)
CPIC: 101941185(SMOX)
ACS: 100556339(smox)
PVT: 110085982(SMOX)
PBI: 103052732(SMOX)
GJA: 107110397(SMOX)
XLA: 108697130(smox.L) 108706499
XTR: 733959(smox)
NPR: 108796203(SMOX)
DRE: 387290(smox) 564675(paox1)
TRU: 101071609(smox)
LCO: 104926977(smox)
NCC: 104951180(smox)
MZE: 101476223(smox)
OLA: 101164210(smox)
XMA: 102226933(smox)
PRET: 103466331(smox)
NFU: 107375292(smox)
CSEM: 107988054(smox)
LCF: 108896624(smox)
HCQ: 109511457(smox)
BPEC: 110165329(smox)
ELS: 105021076(smox)
SFM: 108919046 108924477(smox)
CMK: 103181501(smox)
CIN: 100183817
LHU: 105674493
PXY: 105387330
API: 100159958
DNX: 107165826
ZNE: 110826913
TUT: 107359618
OBI: 106875038
ATH: AT4G29720(PAO5) AT5G13700(PAO1)
LJA: Lj3g3v0824920.1(Lj3g3v0824920.1) Lj6g3v1269730.1(Lj6g3v1269730.1) Lj6g3v1269740.1(Lj6g3v1269740.1)
DOSA: Os01t0710200-00(Os01g0710200) Os03t0193400-00(Os03g0193400) Os09t0368200-00(Os09g0368200) Os09t0368500-01(Os09g0368500)
ATS: 109734081(LOC109734081) 109740105(LOC109740105) 109741342(LOC109741342) 109747506(LOC109747506) 109774256(LOC109774256)
APRO: F751_0494
SSCK: SPSK_01660
MAW: MAC_00210
MAJ: MAA_04956
CMT: CCM_08989
ANI: AN6658.2
ANG: ANI_1_1218084(An09g02560) ANI_1_334114(An13g02480)
ABE: ARB_01705
TVE: TRV_03400
PTE: PTT_12979
 » show all
Taxonomy
Reference
1  [PMID:18422650]
  Authors
Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr
  Title
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
  Journal
FEBS J 275:2795-806 (2008)
DOI:10.1111/j.1742-4658.2008.06419.x
  Sequence
[hsa:54498]
Reference
2  [PMID:12458219]
  Authors
Cervelli M, Polticelli F, Federico R, Mariottini P
  Title
Heterologous expression and characterization of mouse spermine oxidase.
  Journal
J Biol Chem 278:5271-6 (2003)
DOI:10.1074/jbc.M207888200
Reference
3  [PMID:16778015]
  Authors
Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R
  Title
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.
  Journal
Plant Physiol 141:1519-32 (2006)
DOI:10.1104/pp.106.080911
  Sequence
[ath:AT5G13700]
Reference
4  [PMID:12727196]
  Authors
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr
  Title
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
  Journal
Biochem Biophys Res Commun 304:605-11 (2003)
DOI:10.1016/S0006-291X(03)00636-3
  Sequence
[hsa:54498]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.16
IUBMB Enzyme Nomenclature: 1.5.3.16
ExPASy - ENZYME nomenclature database: 1.5.3.16
BRENDA, the Enzyme Database: 1.5.3.16

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