KEGG   ENZYME: 1.5.3.17Help
Entry
EC 1.5.3.17                 Enzyme                                 

Name
non-specific polyamine oxidase;
polyamine oxidase (ambiguous);
Fms1;
AtPAO3
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)
Reaction(IUBMB)
(1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076];
(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [RN:R09077];
(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899];
(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001];
spermidine [CPD:C00315];
N1-acetylspermine [CPD:C02567];
N1-acetylspermidine [CPD:C00612]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027];
putrescine [CPD:C00134];
3-acetamidopropanal [CPD:C18170]
Comment
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1].
The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).
History
EC 1.5.3.17 created 2009
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
Orthology
K13367  polyamine oxidase
K17839  polyamine oxidase
Genes
ATH: AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY: ARALYDRAFT_483403 ARALYDRAFT_486367 ARALYDRAFT_894198
CRB: 17887258 17890473 17895855
CSAT: 104699419 104701179 104750367 104781816 104782814 104785057 104787599 104788143 104792182 109129483
EUS: EUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP: 103830193 103852299 103858041 103866035 103866687
BNA: 106351646 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106434498 106441217 111211981
BOE: 106296723 106318716 106332596 106333466 106336574 106336734
THJ: 104803407 104805661 104821208 104822137
CPAP: 110815019 110815049 110815461
TCC: 18612191
LJA: Lj2g3v3070860.1(Lj2g3v3070860.1) Lj2g3v3070870.1(Lj2g3v3070870.1) Lj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
ZJU: 107416625
DOSA: Os04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
ATS: 109734611(LOC109734611) 109739586(LOC109739586) 109759728(LOC109759728)
SCE: YMR020W(FMS1)
ERC: Ecym_4580
KMX: KLMA_40378(FMS1)
NCS: NCAS_0A12730(NCAS0A12730)
NDI: NDAI_0B01530(NDAI0B01530)
TDL: TDEL_0B06550(TDEL0B06550)
KAF: KAFR_0A02140(KAFR0A02140)
CAL: CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
CAUR: QG37_03853
SLB: AWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
 » show all
Taxonomy
Reference
1  [PMID:18583528]
  Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
  Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
  Journal
Plant Physiol 147:1845-57 (2008)
DOI:10.1104/pp.108.123802
  Sequence
[ath:AT3G59050]
Reference
2  [PMID:1567380]
  Authors
Muller S, Walter RD
  Title
Purification and characterization of polyamine oxidase from Ascaris suum.
  Journal
Biochem J 283 ( Pt 1):75-80 (1992)
Reference
3  [PMID:12670477]
  Authors
Landry J, Sternglanz R
  Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
  Journal
Biochem Biophys Res Commun 303:771-6 (2003)
DOI:10.1016/S0006-291X(03)00416-9
  Sequence
[sce:YMR020W]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.17
IUBMB Enzyme Nomenclature: 1.5.3.17
ExPASy - ENZYME nomenclature database: 1.5.3.17
BRENDA, the Enzyme Database: 1.5.3.17

DBGET integrated database retrieval system