KEGG   ENZYME: 1.5.8.3Help
Entry
EC 1.5.8.3                  Enzyme                                 

Name
sarcosine dehydrogenase;
sarcosine N-demethylase;
monomethylglycine dehydrogenase;
sarcosine:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
BRITE hierarchy
Sysname
sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)
Reaction(IUBMB)
sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein [RN:R00611]
Reaction(KEGG)
Substrate
sarcosine [CPD:C00213];
H2O [CPD:C00001];
electron-transfer flavoprotein [CPD:C04253]
Product
glycine [CPD:C00037];
formaldehyde [CPD:C00067];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A flavoprotein (FMN). Tetrahydrofolate is also a substrate, being converted to N5,N10-methylenetetrahydrofolate.
History
EC 1.5.8.3 created 1972 as EC 1.5.99.1, transferred 2012 to EC 1.5.8.3
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00314  sarcosine dehydrogenase
Genes
HSA: 1757(SARDH)
PTR: 464828(SARDH)
PPS: 100986136(SARDH)
GGO: 101126679(SARDH)
PON: 100172073(SARDH)
NLE: 100581547(SARDH)
MCC: 713289(SARDH)
MCF: 102139165(SARDH)
CSAB: 103239675(SARDH)
RRO: 104669713(SARDH)
RBB: 108513254(SARDH)
CJC: 100396240(SARDH)
SBQ: 101038416(SARDH)
MMU: 192166(Sardh)
RNO: 114123(Sardh)
CGE: 100761121(Sardh) 103158709
NGI: 103742819(Sardh)
HGL: 101717296(Sardh)
CCAN: 109695047(Sardh)
OCU: 103347198(SARDH) 103347553
TUP: 102468288(SARDH)
CFA: 491277(SARDH)
AML: 100477821(SARDH)
UMR: 103679941(SARDH)
ORO: 101363163(SARDH)
FCA: 101082702(SARDH)
PTG: 102957950 102959524(SARDH)
AJU: 106988257(SARDH)
BTA: 614603(SARDH)
BOM: 102286478(SARDH)
BIU: 109566616(SARDH)
PHD: 102331084(SARDH)
CHX: 102176539(SARDH)
OAS: 101110407(SARDH)
SSC: 100154338(SARDH)
CFR: 102509945 102524074(SARDH)
BACU: 103001806(SARDH)
LVE: 103082579(SARDH)
OOR: 101269445(SARDH)
ECB: 100069193(SARDH)
EPZ: 103564041(SARDH)
EAI: 106845348(SARDH)
MYB: 102263827(SARDH)
MYD: 102763367(SARDH)
HAI: 109381141(SARDH)
RSS: 109445986(SARDH)
PALE: 102882489(SARDH)
TMU: 101344177
MDO: 100018850(SARDH)
SHR: 100925921(SARDH)
OAA: 100073946(SARDH)
GGA: 417146(SARDH)
MGP: 100544931(SARDH)
CJO: 107321866(SARDH)
APLA: 101793569(SARDH)
ACYG: 106044083(SARDH)
TGU: 100221431(SARDH)
GFR: 102042792(SARDH)
FAB: 101807275(SARDH)
PHI: 102100623(SARDH)
PMAJ: 107211981(SARDH)
CCAE: 111937046(SARDH) 111943258
CCW: 104688488(SARDH)
FPG: 101910621(SARDH)
FCH: 102055614(SARDH)
CLV: 102089708(SARDH)
EGZ: 104129358(SARDH)
AAM: 106484478(SARDH)
AMJ: 102565496(SARDH)
PSS: 102455800(SARDH)
CMY: 102936719(SARDH)
CPIC: 101938284(SARDH)
ACS: 100567227 103281982(sardh)
PVT: 110089290(SARDH)
GJA: 107106570(SARDH)
XLA: 108698171(sardh.L)
XTR: 100492087(sardh)
DRE: 394103(sardh)
SANH: 107658653 107685122(sardh)
SGH: 107595553(sardh)
IPU: 108276635(sardh)
AMEX: 103038491(sardh)
TRU: 101066393(sardh)
LCO: 104923713(sardh) 109141562
NCC: 104968189(sardh)
MZE: 101464347(sardh)
OLA: 101171504(sardh)
XMA: 102218956(sardh)
PRET: 103473627(sardh)
NFU: 107372413(sardh)
KMR: 108232690(sardh)
CSEM: 103389066(sardh) 103399004
LCF: 108879253(sardh)
SDU: 111238764(sardh)
HCQ: 109517069(sardh)
BPEC: 110174148(sardh)
MALB: 109963453(sardh)
SASA: 106561570(sardh)
ELS: 105014778(sardh)
SFM: 108932522(sardh)
LCM: 102358838(SARDH)
CMK: 103183089(sardh)
CIN: 100184925
SPU: 576973
APLC: 110984820
SKO: 100374616(Sardh)
DME: Dmel_CG6385(Sardh)
DER: 6546660
DPE: 6592810
DSI: Dsimw501_GD25443(Dsim_GD25443)
DWI: 6652181
MDE: 101899451
AAG: 5565677
BIM: 100748086
BTER: 100643113
SOC: 105195588
ACEP: 105618338
PBAR: 105431690
HST: 105184399
DQU: 106746182
CFO: 105253367
LHU: 105673907
PGC: 109857207
PCF: 106788912
NVI: 103316656
MDL: 103575471
TCA: 656849
NVL: 108568210
BMOR: 101743034
PMAC: 106710382
PRAP: 110993772
HAW: 110382187
PXY: 105381895
CLEC: 106666323
FCD: 110856220
LAK: 106167453
EPA: 110254849
ADF: 107344630
HMG: 100197405
SMIN: v1.2.021035.t1(symbB.v1.2.021035.t1)
AAF: AURANDRAFT_22613(SDH1)
SPAR: SPRG_03481
BME: BMEI0684
 » show all
Taxonomy
Reference
1  [PMID:13716069]
  Authors
HOSKINS DD, MACKENZIE CG.
  Title
Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 236:177-83 (1961)
Reference
2  [PMID:13895406]
  Authors
FRISELL WR, MACKENZIE CG.
  Title
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 237:94-8 (1962)
Reference
3  [PMID:6180732]
  Authors
Steenkamp DJ, Husain M
  Title
The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases.
  Journal
Biochem J 203:707-15 (1982)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.3
IUBMB Enzyme Nomenclature: 1.5.8.3
ExPASy - ENZYME nomenclature database: 1.5.8.3
BRENDA, the Enzyme Database: 1.5.8.3
CAS: 37228-65-2 93389-49-2

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