KEGG   ENZYME: 1.5.99.5Help
Entry
EC 1.5.99.5                 Enzyme                                 

Name
methylglutamate dehydrogenase;
N-methylglutamate dehydrogenase;
N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)
Reaction(IUBMB)
N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor [RN:R00609]
Reaction(KEGG)
Substrate
N-methyl-L-glutamate [CPD:C01046];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
formaldehyde [CPD:C00067];
reduced acceptor [CPD:C00030]
Comment
A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.
History
EC 1.5.99.5 created 1976
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K22084  methylglutamate dehydrogenase subunit A
K22085  methylglutamate dehydrogenase subunit B
K22086  methylglutamate dehydrogenase subunit C
K22087  methylglutamate dehydrogenase subunit D
Genes
MLO: mll7303 mll7304 mll7306 mlr1275 mlr1276 msl7305 msr1274
MLN: A9174_20035 A9174_20040 A9174_20045 A9174_20050 A9174_29120 A9174_29125 A9174_29130 A9174_29135
MCI: Mesci_3336 Mesci_3337 Mesci_3338 Mesci_3339 Mesci_5157 Mesci_5158 Mesci_5159 Mesci_5160
MOP: Mesop_2587 Mesop_3827 Mesop_3828 Mesop_3829 Mesop_3830 Mesop_5740 Mesop_5741 Mesop_5743 Mesop_5744
MAM: Mesau_03616 Mesau_03617 Mesau_03618 Mesau_05235 Mesau_05236 Mesau_05238 Mesau_05239
MAMO: A6B35_11055 A6B35_11060 A6B35_11065 A6B35_11070 A6B35_21920 A6B35_21925 A6B35_21930 A6B35_21935
MESO: BSQ44_15720 BSQ44_15725 BSQ44_15730
MESW: A9K65_018045 A9K65_018050 A9K65_018055 A9K65_018060 A9K65_028270 A9K65_028275 A9K65_028280 A9K65_028285
AAK: AA2016_2981 AA2016_2982 AA2016_2983 AA2016_5808 AA2016_5809 AA2016_5810 AA2016_5811
AMIH: CO731_02959 CO731_02960(gcvT_7) CO731_02961 CO731_05435(soxB_5) CO731_05436 CO731_05437(gcvT_18) CO731_05438
BRA: BRADO5878(soxB) BRADO5879(soxD) BRADO5880(soxA) BRADO5881(soxG)
BBT: BBta_1946(soxG) BBta_1947(soxA) BBta_1948(soxD) BBta_1949(soxB)
MEA: Mex_1p1545(soxG) Mex_1p1546 Mex_1p1547(soxD) Mex_1p1548(soxB)
MDI: METDI2319(soxG) METDI2320(soxA) METDI2321(soxD) METDI2322(soxB)
HDI: HDIA_3402(soxB_2) HDIA_3404(gcvT_3) HDIA_3405
RBM: TEF_17850
ANH: A6F65_00104 A6F65_00105(gcvT_1)
AZL: AZL_a09550(soxB) AZL_a09560(soxD) AZL_a09570(soxA) AZL_a09580
 » show all
Taxonomy
Reference
1  [PMID:5028076]
  Authors
Hersh LB, Stark MJ, Worthen S, Fiero MK.
  Title
N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme.
  Journal
Arch Biochem Biophys 150:219-26 (1972)
DOI:10.1016/0003-9861(72)90029-X
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.5
IUBMB Enzyme Nomenclature: 1.5.99.5
ExPASy - ENZYME nomenclature database: 1.5.99.5
BRENDA, the Enzyme Database: 1.5.99.5
CAS: 37217-26-8

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