KEGG   ENZYME: 1.6.2.2Help
Entry
EC 1.6.2.2                  Enzyme                                 

Name
cytochrome-b5 reductase;
cytochrome b5 reductase;
dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase;
reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase;
NADH-ferricytochrome b5 oxidoreductase;
NADH-cytochrome b5 reductase;
NADH 5alpha-reductase ;
NADH-cytochrome-b5 reductase
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a heme protein as acceptor
BRITE hierarchy
Sysname
NADH:ferricytochrome-b5 oxidoreductase
Reaction(IUBMB)
NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5 [RN:R00100]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
ferricytochrome b5 [CPD:C00996]
Product
NAD+ [CPD:C00003];
H+ [CPD:C00080];
ferrocytochrome b5 [CPD:C00999]
Comment
A flavoprotein (FAD).
History
EC 1.6.2.2 created 1961
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K00326  cytochrome-b5 reductase
Genes
HSA: 1727(CYB5R3) 51167(CYB5R4) 51700(CYB5R2) 51706(CYB5R1) 606495(CYB5RL)
PTR: 451005(CYB5R2) 456872(CYB5RL) 458883(CYB5R3) 462857(CYB5R4) 740001(CYB5R1)
PPS: 100967245 100977118 100977566 100978149 100982559
GGO: 101127545 101134045 101139253 101142758 101146890 109025504
PON: 100432451 100432996 100434694 100441723 100450705
NLE: 100584532 100595503 100597887 100603380 100607627
MCC: 695553(CYB5R4) 704519(CYB5R1) 710527(CYB5R2) 714058(CYB5R3) 715211(CYB5RL)
MCF: 102118834 102121558 102131151 102137053(B5R) 102146578
CSAB: 103223639(CYB5R3) 103224775(CYB5RL) 103230295(CYB5R1) 103240023(CYB5R4) 103241038(CYB5R2)
RRO: 104660138 104669273 104669497 104674497 104678634
CJC: 100388244(CYB5R2) 100391835(CYB5RL) 100397461(CYB5R3) 100406679(CYB5R1) 100409710(CYB5R4)
MMU: 109754(Cyb5r3) 230582(Cyb5rl) 266690(Cyb5r4) 320635(Cyb5r2) 72017(Cyb5r1)
RNO: 171015(Cyb5r4) 25035(Cyb5r3) 304805(Cyb5r1) 365345(Cyb5r2) 689035(Cyb5rl)
CFA: 474479(CYB5R3) 474982(CYB5R4) 485367(CYB5R2) 606823(CYB5R1) 610595(CYB5RL)
BTA: 515773(CYB5R3) 516287(CYB5R1) 526748(CYB5RL) 533608(CYB5R4) 536960(CYB5R2)
ECB: 100060530(CYB5RL) 100064917(CYB5R1) 100070258(CYB5R4) 100070581(CYB5R2) 100071050(CYB5R3)
GGA: 112529965 408182(CYB5R2) 418220(CYB5R3) 421837(CYB5R4)
AMJ: 102563183(CYB5R4) 102563640(CYB5RL) 102568029(CYB5R3) 102568851(CYB5R2)
XLA: 108707486(cyb5r1.L) 108712525(cyb5r3.S) 108713798(cyb5r2.L) 108717982(cyb5r4.S) 380169(cyb5r3.L) 495932(cyb5r2.S)
XTR: 100170571(cyb5r3) 100488016(cyb5r1) 549510(cyb5r4) 595026(cyb5r2)
DRE: 324560(cyb5r3) 336553(cyb5r1) 553685(cyb5r4) 751641(cyb5r2)
IPU: 108269273(cyb5r4) 108269377 108279735(Cyb5r3)
DME: Dmel_CG11257(CG11257) Dmel_CG5946(CG5946) Dmel_CG7914(CG7914)
DSI: Dsimw501_GD11452(Dsim_GD11452) Dsimw501_GD12773(Dsim_GD12773) Dsimw501_GD15598(Dsim_GD15598)
CEL: CELE_T05H4.4(T05H4.4) CELE_T05H4.5(hpo-19) CELE_Y52B11A.3(Y52B11A.3)
ATH: AT5G17770(CBR) AT5G20080
LJA: Lj0g3v0004199.1(Lj0g3v0004199.1) Lj1g3v4012860.1(Lj1g3v4012860.1) Lj1g3v4012860.2(Lj1g3v4012860.2) Lj3g3v3688850.2(Lj3g3v3688850.2) Lj3g3v3688850.3(Lj3g3v3688850.3) Lj4g3v1876780.1(Lj4g3v1876780.1)
DOSA: Os01t0174300-01(Os01g0174300) Os01t0814900-01(Os01g0814900) Os05t0488900-01(Os05g0488900)
ATS: 109738521(LOC109738521) 109767086(LOC109767086) 109787016(LOC109787016)
SCE: YIL043C(CBR1) YKL150W(MCR1) YML125C(PGA3)
KMX: KLMA_20468(MCR1) KLMA_40343(CBR1) KLMA_70262(PGA3)
NCS: NCAS_0A13400(NCAS0A13400) NCAS_0B00200(NCAS0B00200) NCAS_0F02340(NCAS0F02340)
NDI: NDAI_0A02640(NDAI0A02640) NDAI_0C03830(NDAI0C03830) NDAI_0C03840(NDAI0C03840) NDAI_0E00200(NDAI0E00200)
TPF: TPHA_0C01210(TPHA0C01210) TPHA_0E02400(TPHA0E02400) TPHA_0G00160(TPHA0G00160) TPHA_0I00150(TPHA0I00150)
TBL: TBLA_0A10090(TBLA0A10090) TBLA_0B01570(TBLA0B01570) TBLA_0B02970(TBLA0B02970) TBLA_0D04190(TBLA0D04190)
TDL: TDEL_0B00310(TDEL0B00310) TDEL_0E03710(TDEL0E03710) TDEL_0H02200(TDEL0H02200)
KAF: KAFR_0A02930(KAFR0A02930) KAFR_0E01700(KAFR0E01700) KAFR_0I01920(KAFR0I01920) KAFR_0L02040(KAFR0L02040)
PIC: PICST_44816(CBR2) PICST_45522(CBR3) PICST_68997(CBR1)
CAL: CAALFM_C405450CA(CBR1) CAALFM_C602040WA(MCR1) CAALFM_CR09110CA(CaO19.7307)
SLB: AWJ20_3146(CBR1) AWJ20_4705(MCR1)
NTE: NEUTE1DRAFT104412(NEUTE1DRAFT_104412) NEUTE1DRAFT116990(NEUTE1DRAFT_116990) NEUTE1DRAFT118894(NEUTE1DRAFT_118894) NEUTE1DRAFT59660(NEUTE1DRAFT_59660)
ANG: ANI_1_1318014(An01g09750) ANI_1_1706134(An15g06810) ANI_1_2078014(An01g00250) ANI_1_2346074(An08g09460) ANI_1_468014(An01g03570) ANI_1_682024(An02g04860)
ABP: AGABI1DRAFT110790(AGABI1DRAFT_110790) AGABI1DRAFT128138(AGABI1DRAFT_128138) AGABI1DRAFT66631(AGABI1DRAFT_66631)
ABV: AGABI2DRAFT116880(AGABI2DRAFT_116880) AGABI2DRAFT182460(AGABI2DRAFT_182460) AGABI2DRAFT189303(AGABI2DRAFT_189303)
DDI: DDB_G0285399(cyb5r1)
DFA: DFA_11618(cyb5r1) DFA_12003
PYO: PY17X_1144700(PY03083)
PCB: PCHAS_114290(PC301543.00.0)
TAN: TA13765
BBO: BBOV_II005800(18.m06482)
SMIN: v1.2.002592.t1(symbB.v1.2.002592.t1) v1.2.011199.t1(symbB.v1.2.011199.t1) v1.2.011199.t2(symbB.v1.2.011199.t2) v1.2.012233.t1(symbB.v1.2.012233.t1) v1.2.013625.t1(symbB.v1.2.013625.t1) v1.2.039258.t1(symbB.v1.2.039258.t1) v1.2.040142.t1(symbB.v1.2.040142.t1)
NOC: Noc_1586
NPH: NP_1230A
 » show all
Taxonomy
Reference
1  [PMID:13563476]
  Authors
MAHLER HR, RAW I, MOLINARI R, DO AMARAL DF.
  Title
Studies of electron transport enzymes. II. Isolation and some properties of a cytochrome-specific reduced diphosphopyridine nucleotide dehydrogenase from pig liver.
  Journal
J Biol Chem 233:230-9 (1958)
Reference
2
  Authors
Strittmatter, P.
  Title
Microsomal cytochrome b5 and cytochrome b5 reductase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 113-145.
Reference
3  [PMID:13475360]
  Authors
STRITTMATTER P, VELICK SF.
  Title
The purification and properties of microsomal cytochrome reductase.
  Journal
J Biol Chem 228:785-99 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.6.2.2
IUBMB Enzyme Nomenclature: 1.6.2.2
ExPASy - ENZYME nomenclature database: 1.6.2.2
BRENDA, the Enzyme Database: 1.6.2.2
CAS: 9032-25-1

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