KEGG   ENZYME: 1.6.3.5Help
Entry
EC 1.6.3.5                  Enzyme                                 

Name
renalase;
alphaNAD(P)H oxidase/anomerase (incorrect);
NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
BRITE hierarchy
Sysname
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
(1) 1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN:R11504];
(2) 1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN:R11505]
Reaction(KEGG)
Substrate
1,2-dihydro-beta-NAD [CPD:C21423];
H+ [CPD:C00080];
O2 [CPD:C00007];
1,6-dihydro-beta-NAD [CPD:C21424]
Product
beta-NAD+ [CPD:C00003];
beta-NADP+ [CPD:C00006];
H2O2 [CPD:C00027]
Comment
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
History
EC 1.6.3.5 created 2014, modified 2015
Orthology
K18208  renalase
Genes
HSA: 55328(RNLS)
PTR: 450581(RNLS)
PPS: 100984167(RNLS)
GGO: 101148106(RNLS)
PON: 100442570(RNLS)
NLE: 100606165(RNLS)
MCC: 708585(RNLS)
MCF: 102135381(RNLS)
CSAB: 103216213(RNLS)
RRO: 104675156(RNLS)
RBB: 108526693(RNLS)
CJC: 100394177(RNLS)
SBQ: 101038706(RNLS)
MMU: 67795(Rnls)
RNO: 361751(Rnls)
CGE: 100759343(Rnls) 100774332
NGI: 103738043(Rnls)
HGL: 101715856(Rnls)
OCU: 100358976(RNLS)
TUP: 102471808(RNLS)
CFA: 610448(RNLS)
AML: 100472491(RNLS)
UMR: 103661923(RNLS)
ORO: 101367093(RNLS)
FCA: 101098402(RNLS)
PTG: 102972926(RNLS)
AJU: 106980975(RNLS)
BTA: 534778(RNLS)
BOM: 102268752(RNLS)
BIU: 109553051(RNLS)
PHD: 102342465(RNLS)
CHX: 102186177(RNLS)
OAS: 101119597(RNLS)
SSC: 100155046(RNLS)
CFR: 102514830(RNLS)
CDK: 105102825(RNLS)
BACU: 102997980(RNLS)
LVE: 103074574(RNLS)
OOR: 101290075(RNLS)
ECB: 100062318(RNLS)
EPZ: 103557426(RNLS)
MYB: 102258362(RNLS)
MYD: 102755609(RNLS)
HAI: 109387538(RNLS)
RSS: 109451025(RNLS)
PALE: 102881691(RNLS)
LAV: 100660092(RNLS)
TMU: 101355498
MDO: 100012984(RNLS)
SHR: 100921129(RNLS)
GGA: 423674(RNLS)
MGP: 104911888(RNLS)
CJO: 107315644(RNLS)
APLA: 101797594(RNLS)
ACYG: 106030728(RNLS)
TGU: 100227044(RNLS)
GFR: 102040917(RNLS)
FAB: 101815597(RNLS)
PHI: 102106894(RNLS)
PMAJ: 107206962(RNLS)
CCAE: 111931621(RNLS)
CCW: 104695102(RNLS)
FPG: 101915468(RNLS)
FCH: 102054531(RNLS)
CLV: 102083736(RNLS)
EGZ: 104125147(RNLS)
AAM: 106495311(RNLS)
ASN: 102377193(RNLS)
AMJ: 102559861(RNLS)
PSS: 102457953(RNLS)
CMY: 102941145(RNLS)
CPIC: 101934780(RNLS)
ACS: 100555221(rnls)
PVT: 110083116(RNLS)
PBI: 103056270(RNLS)
XLA: 447156(rnls.L)
XTR: 100037883(rnls)
NPR: 108788864(RNLS)
DRE: 436880(rnls)
SRX: 107753429 107758426(rnls)
CCAR: 109068041(rnls)
IPU: 108273664(rnls)
AMEX: 103022262(rnls)
LCO: 104936543(rnls)
MZE: 101479856(rnls)
OLA: 101173449(rnls)
XMA: 102217575(rnls)
PRET: 103482133(rnls)
NFU: 107387493(rnls)
KMR: 108228938(rnls)
CSEM: 103382255(rnls)
SDU: 111220182(rnls)
HCQ: 109526490(rnls)
BPEC: 110166069(rnls)
SASA: 106578957(rnls) 106589389
OTW: 112223443(rnls) 112224276
ELS: 105006313(rnls)
SFM: 108939646(rnls)
LCM: 102348794(RNLS)
CMK: 103180807(rnls)
SPU: 591155
APLC: 110991150
SKO: 100372333
API: 103309536
DNX: 107168502
ZNE: 110838682
FCD: 110846279
CRG: 105341980
MYI: 110461431
OBI: 106880270
EPA: 110233087
ADF: 107336859
HMG: 100207627
AQU: 100640327
SMIN: v1.2.038250.t1(symbB.v1.2.038250.t1)
 » show all
Taxonomy
Reference
1  [PMID:15841207]
  Authors
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV
  Title
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.
  Journal
J Clin Invest 115:1275-80 (2005)
DOI:10.1172/JCI24066
  Sequence
[hsa:55328]
Reference
2  [PMID:25531177]
  Authors
Beaupre BA, Hoag MR, Roman J, Forsterling FH, Moran GR
  Title
Metabolic function for human renalase: oxidation of isomeric forms of beta-NAD(P)H that are inhibitory to primary metabolism.
  Journal
Biochemistry 54:795-806 (2015)
DOI:10.1021/bi5013436
Other DBs
ExplorEnz - The Enzyme Database: 1.6.3.5
IUBMB Enzyme Nomenclature: 1.6.3.5
ExPASy - ENZYME nomenclature database: 1.6.3.5
BRENDA, the Enzyme Database: 1.6.3.5

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