KEGG   ENZYME: 1.6.5.9Help
Entry
EC 1.6.5.9                  Enzyme                                 

Name
NADH:ubiquinone reductase (non-electrogenic);
ubiquinone reductase (ambiguous);
coenzyme Q reductase (ambiguous);
dihydronicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous);
DPNH-coenzyme Q reductase (ambiguous);
DPNH-ubiquinone reductase (ambiguous);
NADH-coenzyme Q oxidoreductase (ambiguous);
NADH-coenzyme Q reductase (ambiguous);
NADH-CoQ oxidoreductase (ambiguous);
NADH-CoQ reductase (ambiguous);
NADH-ubiquinone reductase (ambiguous);
NADH-ubiquinone oxidoreductase (ambiguous);
reduced nicotinamide adenine dinucleotide-coenzyme Q reductase (ambiguous);
NADH-Q6 oxidoreductase (ambiguous);
NADH2 dehydrogenase (ubiquinone) (ambiguous)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADH:ubiquinone oxidoreductase
Reaction(IUBMB)
NADH + H+ + ubiquinone = NAD+ + ubiquinol [RN:R02163]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
ubiquinone [CPD:C00399]
Product
NAD+ [CPD:C00003];
ubiquinol [CPD:C00390]
Comment
A flavoprotein (FAD). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH.
History
EC 1.6.5.9 created 2011
Orthology
K17871  NADH:ubiquinone reductase (non-electrogenic)
K17872  NADH:ubiquinone reductase (non-electrogenic)
Genes
RSS: 109441606 109442301
CIN: 100182249
SPU: 100888391
APLC: 110986378
SKO: 100373395
LGI: LOTGIDRAFT_224073
CRG: 105321592
MYI: 110463105
LAK: 106166048
NVE: NEMVE_v1g189645
EPA: 110235097
ADF: 107342464
ATH: AT1G07180(NDA1) AT2G20800(NDB4) AT2G29990(NDA2) AT4G05020(NDB2) AT4G21490(NDB3) AT4G28220(NDB1) AT5G08740(NDC1)
LJA: Lj0g3v0132519.1(Lj0g3v0132519.1) Lj2g3v2279580.1(Lj2g3v2279580.1) Lj2g3v2279580.2(Lj2g3v2279580.2) Lj2g3v2279580.3(Lj2g3v2279580.3) Lj3g3v2873580.1(Lj3g3v2873580.1) Lj3g3v2873590.1(Lj3g3v2873590.1) Lj4g3v0445550.1(Lj4g3v0445550.1) Lj4g3v0447890.1(Lj4g3v0447890.1) Lj4g3v2827910.1(Lj4g3v2827910.1) Lj4g3v2827910.2(Lj4g3v2827910.2) Lj6g3v2083620.1(Lj6g3v2083620.1)
DOSA: Os01t0830100-01(Os01g0830100) Os05t0331200-01(Os05g0331200) Os06t0214900-01(Os06g0214900) Os06t0684000-01(Os06g0684000) Os07t0564500-01(Os07g0564500) Os08t0141400-01(Os08g0141400)
ATS: 109733687(LOC109733687) 109746764(LOC109746764) 109747592(LOC109747592) 109761177(LOC109761177) 109769370(LOC109769370) 109779678(LOC109779678) 109783120(LOC109783120)
ZMA: 100274336(pco100812) 100275557(pco125920) 100279865 100282489(si618008g06(715)) 100382694 103629626 103636591
SCE: YDL085W(NDE2) YML120C(NDI1) YMR145C(NDE1)
KMX: KLMA_10279(NDI1) KLMA_10695(NDE1)
NCS: NCAS_0A03930(NCAS0A03930) NCAS_0B00240(NCAS0B00240) NCAS_0D01150(NCAS0D01150)
NDI: NDAI_0E00230(NDAI0E00230) NDAI_0E01660(NDAI0E01660) NDAI_0H03010(NDAI0H03010)
TPF: TPHA_0C04800(TPHA0C04800) TPHA_0G02580(TPHA0G02580)
TBL: TBLA_0B08910(TBLA0B08910) TBLA_0D03320(TBLA0D03320)
TDL: TDEL_0B00230(TDEL0B00230) TDEL_0G03120(TDEL0G03120)
KAF: KAFR_0A02890(KAFR0A02890) KAFR_0B05060(KAFR0B05060) KAFR_0F02920(KAFR0F02920)
PIC: PICST_66598(NDE1)
SPAA: SPAPADRAFT_140814(NDE1)
CAUR: QG37_05911
SLB: AWJ20_3145(NDE2) AWJ20_806(NDE1)
NCR: NCU08980(nde-2)
NTE: NEUTE1DRAFT122492(NEUTE1DRAFT_122492)
MGR: MGG_06276
SSCK: SPSK_04110
MAW: MAC_01655
MAJ: MAA_02488
CMT: CCM_09437
BFU: BCIN_08g03710(Bcnde2)
MBE: MBM_01156
ANI: AN1094.2
ANG: ANI_1_610074(An08g04240)
ABE: ARB_03116
TVE: TRV_07068
PTE: PTT_10249
CNE: CNA07650
CNB: CNBA7480
ABP: AGABI1DRAFT77116(NDE1)
ABV: AGABI2DRAFT227697(NDE2)
SLA: SERLADRAFT_478362(NDE1)
SMIN: v1.2.023058.t1(symbB.v1.2.023058.t1) v1.2.027571.t1(symbB.v1.2.027571.t1) v1.2.027967.t1(symbB.v1.2.027967.t1) v1.2.035097.t1(symbB.v1.2.035097.t1) v1.2.040380.t1(symbB.v1.2.040380.t1)
NGD: NGA_0209201(NDH) NGA_0211800(NDH)
 » show all
Taxonomy
Reference
1
  Authors
Moller, I.M, and Palmer, J.M.
  Title
Direct evidence for the presence of a rotenone-resistant NADH dehydrogenase on the inner surface of plant mitochondria.
  Journal
Physiol Plant 54:267-274 (1982)
Reference
2  [PMID:3138118]
  Authors
de Vries S, Grivell LA
  Title
Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae.
  Journal
Eur J Biochem 176:377-84 (1988)
DOI:10.1111/j.1432-1033.1988.tb14292.x
  Sequence
[sce:YML120C]
Reference
3  [PMID:10381390]
  Authors
Kerscher SJ, Okun JG, Brandt U
  Title
A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica.
  Journal
J Cell Sci 112 ( Pt 14):2347-54 (1999)
  Sequence
Reference
4  [PMID:15725055]
  Authors
Rasmusson AG, Soole KL, Elthon TE
  Title
Alternative NAD(P)H dehydrogenases of plant mitochondria.
  Journal
Annu Rev Plant Biol 55:23-39 (2004)
DOI:10.1146/annurev.arplant.55.031903.141720
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.9
IUBMB Enzyme Nomenclature: 1.6.5.9
ExPASy - ENZYME nomenclature database: 1.6.5.9
BRENDA, the Enzyme Database: 1.6.5.9
CAS: 9028-04-0

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