KEGG   ENZYME: 1.7.1.12Help
Entry
EC 1.7.1.12                 Enzyme                                 

Name
N-hydroxy-2-acetamidofluorene reductase;
N-hydroxy-2-acetylaminofluorene reductase;
NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-acetamidofluorene:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+ [RN:R04046 R04047]
Reaction(KEGG)
Substrate
2-acetamidofluorene [CPD:C02778];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
N-hydroxy-2-acetamidofluorene [CPD:C03954];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.
History
EC 1.7.1.12 created 1989 as EC 1.6.6.13, transferred 2002 to EC 1.7.1.12
Reference
1  [PMID:5780838]
  Authors
Gutmann HR, Erickson RR.
  Title
The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction.
  Journal
J Biol Chem 244:1729-40 (1969)
Reference
2  [PMID:4074379]
  Authors
Kitamura S, Tatsumi K.
  Title
Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol.
  Journal
Biochem Biophys Res Commun 133:67-74 (1985)
DOI:10.1016/0006-291X(85)91842-X
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.12
IUBMB Enzyme Nomenclature: 1.7.1.12
ExPASy - ENZYME nomenclature database: 1.7.1.12
BRENDA, the Enzyme Database: 1.7.1.12
CAS: 99890-08-1

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