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Entry
EC 1.7.2.5                  Enzyme                                 

Name
nitric oxide reductase (cytochrome c)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
nitrous oxide:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
nitrous oxide + 2 ferricytochrome c + H2O = 2 nitric oxide + 2 ferrocytochrome c + 2 H+ [RN:R00294]
Reaction(KEGG)
Substrate
nitrous oxide [CPD:C00887];
ferricytochrome c [CPD:C00125];
H2O [CPD:C00001]
Product
nitric oxide [CPD:C00533];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme from Pseudomonas aeruginosa contains a dinuclear centre comprising a non-heme iron centre and heme b3, plus heme c, heme b and calcium; the acceptor is cytochrome c551
History
EC 1.7.2.5 created 1992 as EC 1.7.99.7, transferred 2011 to EC 1.7.2.5
Pathway
ec00910  Nitrogen metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K04561  nitric oxide reductase subunit B
Genes
EBT: EBL_c06330 EBL_c06360
HPR: PARA_00150(norB)
MSU: MS0293(norB) MS0294(norB)
ASU: Asuc_1602
AAP: NT05HA_1475
AAZ: ADJ80_00065
GAN: UMN179_01663
SACZ: AOT14_33560
PSU: Psesu_0363
PSUW: WQ53_05760
PPR: PBPRB1054(NE2004)
PAE: PA0524(norB)
PAEV: N297_536(norB)
PAEI: N296_536(norB)
PAU: PA14_06830(norB)
PAP: PSPA7_0625(norB)
PAG: PLES_05211(norB)
PAF: PAM18_0523(norB)
PNC: NCGM2_5672(norB)
PAEB: NCGM1900_0535(norB)
PAEP: PA1S_02645
PAEM: U769_02670
PAEL: T223_02645
PAEU: BN889_00605(norB)
PAEG: AI22_01260
PAEC: M802_535(norB)
PAEO: M801_536(norB)
PMK: MDS_0132
PCQ: PcP3B5_02600(norB_1) PcP3B5_29280(norB_2)
PFE: PSF113_3431(norB2) PSF113_3759(norB1)
PMAN: OU5_0149 OU5_0452(norB)
PSA: PST_3521(norB)
PSR: PSTAA_3618(norB)
PSYC: DABAL43B_0852(norB)
MCT: MCR_0131(norB)
MCS: DR90_1764
MCAT: MC25239_00168(norB)
SDN: Sden_1980
SFR: Sfri_3253
SAZ: Sama_0728
SLO: Shew_0657
SSE: Ssed_3822
SHL: Shal_3554
SWD: Swoo_0761
SWP: swp_0833
ILO: IL0186
CPS: CPS_0601(norB)
PHA: PSHAa2417(nor)
PTN: PTRA_a2897(norB)
PNG: PNIG_a3090(norB)
MAQ: Maqu_3115
MHC: MARHY3014(norB) MARHY3054(norB)
MBS: MRBBS_3150(norB)
MVS: MVIS_0531
CJA: CJA_1546(norB)
LPN: lpg2236
LPH: LPV_2499
LPO: LPO_2308
LPM: LP6_2264
LPF: lpl2162
LPP: lpp2189
LPC: LPC_1704
LPA: lpa_03215(norB)
LPE: lp12_2228
LLO: LLO_1387
LLG: 44548918_01066(norB)
TMC: LMI_1611
MCA: MCA2400
MAH: MEALZ_1161(norB)
TIG: THII_0335
NOC: Noc_1849
NHL: Nhal_1556
NTT: TAO_0114
AEH: Mlg_2118
TNI: TVNIR_1656(norB_[H])
GAI: IMCC3135_17600(norB)
HCH: HCH_00713 HCH_04410(norB)
HCO: LOKO_01717(norB)
HBE: BEI_3589(norB)
ADI: B5T_03073
APAC: S7S_01060
AXE: P40_14310
KKO: Kkor_2038
OAI: OLEAN_C21750(norB)
OCE: GU3_00450
SVA: SVA_0936
TBN: TBH_C2146
ENM: EBS_1570(norB)
NME: NMB1622(norB)
NMP: NMBB_1862
NMQ: NMBM04240196_0602(norB)
NMZ: NMBNZ0533_1599(norB)
NMA: NMA1886
NMW: NMAA_1352(norB)
NMX: NMA510612_2117(norB)
NMC: NMC1548(nor)
NMN: NMCC_1531(nor)
NMI: NMO_1451(norB)
NGO: NGO1275
NGK: NGK_1489
NLA: NLA_6500(nor)
KKI: KKKWG1_1534(norB)
ECOR: SAMEA4412678_0011(norB)
CVI: CV_3494(norB)
PSE: NH8B_1416(norB)
RSO: RSp1505(norB)
RSL: RPSI07_3196(norB)
RSN: RSPO_m00042(norB)
RSM: CMR15_mp30149(norB)
RSE: F504_4975
RPI: Rpic_4013
REH: H16_B2323(norB2) PHG244(norB)
CNC: CNE_2c22880(norB)
RME: Rmet_3167(norB)
CTI: RALTA_B2087(norB)
BMA: BMA0633 BMAA0799(norB)
BPS: BPSL2351
BPSA: BBU_3209
BPSO: X996_1813
BTD: BTI_1283
BOK: DM82_1966
BOC: BG90_2746
BUL: BW21_1431
BPT: Bpet3560 Bpet4049(norB)
AXX: ERS451415_02175(norB_1)
BPSI: IX83_07770
AFQ: AFA_15965
ODI: ODI_R1042
RFR: Rfer_1886
PNA: Pnap_1328
HYB: Q5W_18285
HAR: HEAR0048(norZ) HEAR1667
LCH: Lcho_1468
RGE: RGE_07190(norB)
PBH: AAW51_4190(norB) AAW51_4198(norB)
NEU: NE2004(norB)
NET: Neut_0520
MMB: Mmol_1051
SLT: Slit_1122
SDR: SCD_n00457(norB)
EBA: ebA179(norB)
DSU: Dsui_3110
DAR: Daro_3191
AZO: azo3089(norB)
AZA: AZKH_1713(norB)
AOA: dqs_3224
TCL: Tchl_2611
SULR: B649_06255
CCV: CCV52592_1608(norZ)
CCO: CCC13826_1535(norZ)
CCOC: CCON33237_0618(norZ)
CGRA: CGRAC_0972(norZ)
ABU: Abu_1354(norB)
ABT: ABED_1263
ABL: A7H1H_1353(norB)
NIS: NIS_1795
SUN: SUN_0244
GME: Gmet_3493(norZ)
GBM: Gbem_1248 Gbem_3901(norZ)
GEO: Geob_0018(norZ)
GEB: GM18_1107
SCL: sce3281(norB) sce8584
SFU: Sfum_2932
BBA: Bd2599(norB)
BBAT: Bdt_2743(norB)
BBAC: EP01_09125
AMIH: CO731_02676(norB)
PLA: Plav_1004
RBS: RHODOSMS8_01459(norB)
SME: SMa1273(norB)
SMI: BN406_04415(norB)
SMEL: SM2011_a1273(norB)
SMER: DU99_22595
SMD: Smed_6288
RHI: NGR_c09860(norB)
SFH: SFHH103_00921(norB)
SFD: USDA257_c38450(norB)
SAME: SAMCFNEI73_Ch1305(norB)
EAD: OV14_b0152(norB)
ATU: Atu4388(norB)
RET: RHE_PF00516(norB)
REL: REMIM1_PF00202(norB)
RIR: BN877_p0535(norB)
RGA: RGR602_PC02100(norB)
RHN: AMJ98_PB00144(norB)
RPHA: AMC79_PA00182(norB)
RHT: NT26_3644(norB)
RHX: AMK02_PB00158(norB)
NGL: RG1141_CH34820(norB)
NGG: RG540_CH35580(norB)
SHZ: shn_16565
BME: BMEII0998
BMEL: DK63_2258(norB)
BMZ: BM28_B0240(norB)
BMG: BM590_B0240(norB)
BMEE: DK62_3149(norB)
BMF: BAB2_0954
BMB: BruAb2_0930(norB)
BABO: DK55_2897(norB)
BABR: DO74_2212(norB)
BABT: DK49_2342(norB)
BABB: DK48_2900(norB)
BABU: DK53_2900(norB)
BABS: DK51_2386(norB)
BABC: DO78_2157(norB)
BMS: BRA0249(norB)
BSI: BS1330_II0246(norB)
BSF: BSS2_II0235(norB)
BSZ: DK67_2268(norB)
BSV: BSVBI22_B0245(norB)
BCS: BCAN_B0250(norB)
BOL: BCOUA_II0249(norB)
BCAR: DK60_3122(norB)
BCAS: DA85_11695
BMR: BMI_II243(norB)
BPP: BPI_II244(norB)
BPV: DK65_2228(norB)
BVL: BF3285c2_0921(norB)
OAN: Oant_4387
OAH: DR92_3857(norB)
BJA: blr3215(norB)
BRA: BRADO1777(norB)
BBT: BBta_2089(norB)
BRS: S23_47820(norB)
AOL: S58_57710
BRAD: BF49_1470
BRO: BRAD285_5519(norB)
RPA: RPA1456(norB)
RPE: RPE_0621
RPT: Rpal_1642
XAU: Xaut_3044
SNO: Snov_1155
MSL: Msil_1516
HDN: Hden_0582
FIL: BN1229_v1_3123(norB)
FIY: BN1229_v1_2797(norB)
RBM: TEF_15505
CSE: Cseg_3031
PZU: PHZ_c0619(norB)
SIL: SPOA0216(norB)
RSP: RSP_0323(norB)
RDE: RD1_1561(norB)
RLI: RLO149_c031420(norB)
PDE: Pden_2483
PAMN: pAMV1p0147(norB)
DSH: Dshi_3184(norB)
PSF: PSE_4552(norB) PSE_p0187
PGA: PGA1_262p01220(norB)
PGL: PGA2_239p1400(norB)
PGD: Gal_03858
PHP: PhaeoP97_03832(norB)
PPIC: PhaeoP14_03621(norB)
CID: P73_0916
SPSE: SULPSESMR1_04756(norB)
AHT: ANTHELSMS3_03933(norB)
SPHP: LH20_13010
SGI: SGRAN_3801(norB)
SPHU: SPPYR_0790
SPHM: G432_20100
RCE: RC1_3976(norB)
MAG: amb2944
MGY: MGMSRv2__1716(norB)
MAGX: XM1_4021(norB)
AZL: AZL_c02070(norB)
ALI: AZOLI_p30086(norB)
ABS: AZOBR_p350037(norB)
TXI: TH3_16230
MAGQ: MGMAQ_1206(norB)
MGM: Mmc1_0120
PGV: SL003B_0580(norB)
BLI: BL01473
BLD: BLi02084(norB)
BLH: BaLi_c21500(norB)
BGY: BGLY_2370
GKA: GK0758
GTN: GTNG_0643(norZ)
GGH: GHH_c07080(norB)
GEA: GARCT_00734(norB)
AAMY: GFC30_1105
SAR: SAR0261
SUE: SAOV_0204
SUJ: SAA6159_00241(norB)
SUK: SAA6008_00238(norB)
SUG: SAPIG0277
SAUA: SAAG_00745
SAUB: C248_0252
SHU: SHYC_02260(norB)
SAGQ: EP23_07875
BTS: Btus_2112
LFE: LAF_1643
LFR: LC40_1039
LFF: LBFF_1818
DSY: DSY1165
DHD: Dhaf_2253
VPR: Vpar_1513
VRM: 44547418_01606(norB)
PFT: JBW_03164
LPIL: LIP_2753
MAV: MAV_4011
MAVD: NF84_18325
MAVR: LA63_18515
MAVA: LA64_18505
MMC: Mmcs_1569
MKM: Mkms_1593
MJL: Mjls_1539
MTHN: 4412656_00818(norB)
MTER: 4434518_02961(norB)
CDI: DIP2249
CDIP: ERS451417_02271(norB_2)
CPU: cpfrc_00128(nor)
CPL: Cp3995_0128(norB)
CPG: Cp316_0140(norB)
CPP: CpP54B96_0131(norB)
CPK: Cp1002_0125(norB)
CPQ: CpC231_0127(norB)
CPX: CpI19_0128(norB)
CPZ: CpPAT10_0127(norB)
COR: Cp267_0135(norB)
COP: Cp31_2302(norZ)
COS: Cp4202_0124(norB)
COI: CpCIP5297_0136(norB)
COE: Cp258_0138(norB)
COU: Cp162_0131(norB)
CPSE: CPTA_00655
CPSU: CPTB_00878
CPSF: CPTC_00540
CSP: WM42_0850
REQ: REQ_03280
PAC: PPA1975
PAW: PAZ_c20630(norB)
PACC: PAC1_10095
PACH: PAGK_1889
CACN: RN83_10175
PFR: PFREUD_00980(norB)
PFRE: RM25_2169
ACIJ: JS278_00775(norB)
MPH: MLP_45230
SYN: sll0450(norB)
SYZ: MYO_131250(norB)
SYY: SYNGTS_3089(norB)
SYT: SYNGTI_3088(norB)
SYS: SYNPCCN_3087(norB)
SYQ: SYNPCCP_3087(norB)
HHG: XM38_033790(norB)
CTHE: Chro_3365
TSC: TSC_c17600(norB)
PUV: PUV_24980(norB)
WCH: wcw_0480(norB)
MIN: Minf_0042(norB)
PLH: VT85_24170(norB)
FMR: Fuma_00659(norB)
TTF: THTE_3645
GES: VT84_24800(norB)
PBOR: BSF38_01387(norB)
LBI: LEPBI_I2954(norB)
LBF: LBF_2854(norB)
SUS: Acid_2936
ABAC: LuPra_02427(norB)
PMUC: ING2E5A_1761(norB)
PSAC: PSM36_2451
CPI: Cpin_5786
SMIZ: 4412673_03223(norB)
GFL: GRFL_0382
FJO: Fjoh_2413
FJG: BB050_00225(norB)
COC: Coch_1575
CBAL: M667_16140
CBAT: M666_16130
ZGA: ZOBELLIA_4311(norBC)
EAO: BD94_0986
ELB: VO54_01677(norB)
MYR: MYRA21_0477(norB)
MPW: MPR_3009
TMAR: MARIT_0474(norBC)
AALG: AREALGSMS7_01831(norB)
MARF: CJ739_3259
HTH: HTH_0283(norB)
CABY: Cabys_1327(norZ)
FPL: Ferp_1340
HHB: Hhub_2675
HMA: rrnAC2272(norB)
HHI: HAH_2739(norB)
HMU: Hmuk_1980
HVO: HVO_2147
HME: HFX_2188(norB)
HLA: Hlac_1902
NAT: NJ7G_0368
SSO: SSO1571(norB-1)
SOL: Ssol_2401
SSOA: SULA_2427
SSOL: SULB_2428
SSOF: SULC_2425
SIH: SiH_0816
SIR: SiRe_0538
PAI: PAE3603
PCL: Pcal_1908
PAS: Pars_0502
PYR: P186_0748
POG: Pogu_1845
CMA: Cmaq_0286
TUZ: TUZN_1529
VDI: Vdis_1451
ASC: ASAC_0647
 » show all
Taxonomy
Reference
1  [PMID:9748316]
  Authors
Hendriks J, Warne A, Gohlke U, Haltia T, Ludovici C, Lubben M, Saraste M
  Title
The active site of the bacterial nitric oxide reductase is a dinuclear iron center.
  Journal
Biochemistry 37:13102-9 (1998)
DOI:10.1021/bi980943x
Reference
2  [PMID:9623801]
  Authors
Hendriks J, Gohlke U, Saraste M
  Title
From NO to OO: nitric oxide and dioxygen in bacterial respiration.
  Journal
J Bioenerg Biomembr 30:15-24 (1998)
Reference
3  [PMID:2542222]
  Authors
Heiss B, Frunzke K, Zumft WG.
  Title
Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri.
  Journal
J Bacteriol 171:3288-97 (1989)
DOI:10.1128/JB.171.6.3288-3297.1989
  Sequence
Reference
4  [PMID:9521721]
  Authors
Cheesman MR, Zumft WG, Thomson AJ
  Title
The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases.
  Journal
Biochemistry 37:3994-4000 (1998)
DOI:10.1021/bi972437y
  Sequence
Reference
5  [PMID:15504726]
  Authors
Kumita H, Matsuura K, Hino T, Takahashi S, Hori H, Fukumori Y, Morishima I, Shiro Y
  Title
NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single  turnover cycle.
  Journal
J Biol Chem 279:55247-54 (2004)
DOI:10.1074/jbc.M409996200
Reference
6  [PMID:21109633]
  Authors
Hino T, Matsumoto Y, Nagano S, Sugimoto H, Fukumori Y, Murata T, Iwata S, Shiro Y
  Title
Structural basis of biological N2O generation by bacterial nitric oxide reductase.
  Journal
Science 330:1666-70 (2010)
DOI:10.1126/science.1195591
  Sequence
[pae:PA0524]
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.5
IUBMB Enzyme Nomenclature: 1.7.2.5
ExPASy - ENZYME nomenclature database: 1.7.2.5
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.2.5
BRENDA, the Enzyme Database: 1.7.2.5

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