KEGG   ENZYME: 1.7.2.8Help
Entry
EC 1.7.2.8                  Enzyme                                 

Name
hydrazine dehydrogenase;
HDH
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
hydrazine:ferricytochrome c oxidoreductase
Reaction(IUBMB)
hydrazine + 4 ferricytochrome c = N2 + 4 ferrocytochrome c [RN:R07174]
Reaction(KEGG)
Substrate
hydrazine [CPD:C05361];
ferricytochrome c [CPD:C00125]
Product
N2 [CPD:C00697];
ferrocytochrome c [CPD:C00126]
Comment
The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool.
History
EC 1.7.2.8 created 2003 as EC 1.7.99.8, modified 2010, transferred 2016 to EC 1.7.2.8
Pathway
ec00910  Nitrogen metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20935  hydrazine dehydrogenase
Genes
KST: KSMBR1_2369(hdh)
Taxonomy
Reference
1  [PMID:10820012]
  Authors
Schalk J, de Vries S, Kuenen JG, Jetten MS.
  Title
Involvement of a novel hydroxylamine oxidoreductase in anaerobic ammonium oxidation.
  Journal
Biochemistry 39:5405-12 (2000)
DOI:10.1021/bi992721k
Reference
2  [PMID:11404106]
  Authors
Jetten MS, Wagner M, Fuerst J, van Loosdrecht M, Kuenen G, Strous M.
  Title
Microbiology and application of the anaerobic ammonium oxidation ('anammox') process.
  Journal
Curr Opin Biotechnol 12:283-8 (2001)
DOI:10.1016/S0958-1669(00)00211-1
Reference
3  [PMID:21964329]
  Authors
Kartal B, Maalcke WJ, de Almeida NM, Cirpus I, Gloerich J, Geerts W, Op den Camp HJ, Harhangi HR, Janssen-Megens EM, Francoijs KJ, Stunnenberg HG, Keltjens JT, Jetten MS, Strous M.
  Title
Molecular mechanism of anaerobic ammonium oxidation.
  Journal
Nature 479:127-30 (2011)
DOI:10.1038/nature10453
  Sequence
Reference
4  [PMID:23210799]
  Authors
Kartal B, de Almeida NM, Maalcke WJ, Op den Camp HJ, Jetten MS, Keltjens JT
  Title
How to make a living from anaerobic ammonium oxidation.
  Journal
FEMS Microbiol Rev 37:428-61 (2013)
DOI:10.1111/1574-6976.12014
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.8
IUBMB Enzyme Nomenclature: 1.7.2.8
ExPASy - ENZYME nomenclature database: 1.7.2.8
BRENDA, the Enzyme Database: 1.7.2.8
CAS: 9075-43-8

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