KEGG   ENZYME: 1.7.3.3
Entry
EC 1.7.3.3                  Enzyme                                 
Name
factor-independent urate hydroxylase;
uric acid oxidase;
uricase;
uricase II;
urate oxidase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With oxygen as acceptor
Sysname
urate:oxygen oxidoreductase
Reaction(IUBMB)
urate + O2 + H2O = 5-hydroxyisourate + H2O2 [RN:R02106]
Reaction(KEGG)
R02106;
(other) R07981
Substrate
urate [CPD:C00366];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
5-hydroxyisourate [CPD:C11821];
H2O2 [CPD:C00027]
Comment
This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).
History
EC 1.7.3.3 created 1961, modified 2002, modified 2005, modified 2010
Pathway
ec00230  Purine metabolism
ec00232  Caffeine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00365  urate oxidase
K16838  urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Genes
GGO101139849
NLE100597726
MCC714004
MCF102117077
CSAB103224536
CATY105593567
PANU100998784
TGE112628445
RRO104677513
RBB108527687
TFN117092165
PTEH111540355
CJC100397154
SBQ101040936
MMUR105861795
OGA100956247
MMU22262(Uox)
MCAL110291256
MPAH110320533
RNO114768(Uox)
MCOC116094386
MUN110555015
CGE100768251
PLEU114698269
NGI103728098
HGL101719675
CPOC100733081
CCAN109688705
DORD105987044
DSP122103685
NCAR124975056
OCU100009266(UOX)
OPI101526796
TUP102500418
CFA490189(UOX)
VVP112924412
VLG121487812
AML100470134
UMR103662970
UAH113254484
UAR123794967
ELK111143395
LLV125098225
MPUF101691492
ORO101366343
EJU114208481
ZCA113935935
MLX118019225
FCA101096750
PYU121027381
PBG122480700
PTG102971100
PPAD109246177
AJU106973351
HHV120241661
BTA514113(UOX)
BOM102267915
BIU109556136
BBUB102411007
CHX102168228
OAS101109838
ODA120856945
CCAD122436770
SSC397510(UOX)
CFR102505313
CBAI105075495
CDK105095038
VPC102527220
BACU103009966
LVE103070467
OOR101275718
DLE111178377
PCAD102983042
PSIU116759011
ECB100064919
EPZ103557286
EAI106824012
MYB102244414
MYD102751767
MMYO118676280
MLF102440467
MNA107543171
PKL118722346
HAI109385433
DRO112309394
SHON118997369
AJM119062885
PDIC114497513
PHAS123816544
MMF118626625
RFQ117027787
PALE102878680
PGIG120583274
PVP105289066
RAY107511587
MJV108386581
TOD119235842
SARA101539405
LAV100668450
TMU101357598
DNM101420609
MDO100012925
SHR100917431
PCW110209927
OAA100078972
GGA101747367
PCOC116233357
MGP100551010
CJO107317543
NMEL110402305
APLA101797537
ACYG106033995
AFUL116491890
TGU100189932
LSR110468816
SCAN103815159
PMOA120510834
OTC121345123
PRUF121362003
GFR102040716
FAB101806442
PHI102109233
PMAJ107208239
CCAE111932859
CCW104695300
ETL114064914
ZAB102068609
FPG101917753
CLV102096622
EGZ104122902
NNI104015567
ACUN113482838
PADL103925216
ACHC115349367
AAM106499688
AROW112961906
NPD112946255
DNE112993126
ASN102373915
AMJ102571917(UOX)
CPOO109307346
GGN109305327
PSS102453497 102453977
CMY102932244 102932468
CPIC101936730 101944737
TST117882030 117882031
CABI116835757 116835765
MRV120370462 120370465
ACS100552598
PVT110079741
SUND121930000
PBI103058911
PMUR107285242
PGUT117677350
VKO123024487
PMUA114598436
ZVI118089130
GJA107117302
STOW125432806
XLA108714977 399031(uox.L)
XTR496896(uox)
NPR108791380
RTEM120945980
BBUF120979288
BGAR122943160
DRE436604(uox)
SRX107742901
SANH107658581 107669002
SGH107560424
CAUA113054948
PPRM120464182(uox)
MAMB125257006(uox)
IPU100528126(uox)
PHYP113529137
SMEO124391089(uox)
TFD113651623(uox)
AMEX103030682
EEE113581895
TRU101078943
TNGGSTEN00022862G001
LCO104931943
NCC104941345
CGOB115006622
ELY117253362(uox)
PLEP121966164(uox)
SLUC116055423(uox)
ECRA117950664(uox)
PFLV114561451
GAT120823961(uox)
PPUG119216288(uox)
MSAM119900633(uox)
CUD121512608(uox)
MZE101475077
ONL100711225
OAU116333045(uox)
OLA101159660
OML112150775(uox)
XMA102230976
XCO114150834
XHE116725610 116727894
PRET103464157
PFOR103130861 103130884
PLAI106941472 106959866
PMEI106923626 106930008
GAF122838692(uox)
CVG107087215
CTUL119774617(uox)
GMU124873961(uox)
NFU107392713
KMR108234387(uox)
ALIM106511397
NWH119430624(uox)
AOCE111586381
CSEM103392251
POV109625259
SSEN122780818(uox)
HHIP117759928(uox)
LCF108881276
SDU111230334
SLAL111658501
XGL120790336(uox)
HCQ109522038
BPEC110160092
MALB109958355
SASA100136464
OTW112217413(uox)
OMY110521955(uox)
OGO123994963(uox)
ONE115139545
SALP111976044 112080518
SNH120054592(uox)
ELS105008143
SFM108923494
PKI111860542
AANG118225826(uox)
LOC102689735
PSPA121331102(uox)
ARUT117411523(uox)
LCM102360643
CMK103174706(uox)
RTP109916159
BFO118421545
BBEL109484575
SPU588974
APLC110981412 110981429
SKO100368654
DMEDmel_CG7171(Uro)
DER6541683
DSE6611569
DSIDsimw501_GD23486(Dsim_GD23486)
DYADyak_GE14614
DAN6498135
DSR110177005
DPODpse_GA20153(Dpse_Uro)
DPE113565904 6589893
DMN108162944
DWI6644051 6644053
DGR6563033 6563721
DMODmoj_GI24222
DNV108651295
DHE111594568
DVI116650345 6632471
CCAT101459269 101459637
BOD106615260 106615274
MDE101898809
SCAC106083689
LCQ111689741
AGAAgaP_AGAP008440
ACOZ120958706
AARA120902654
AAG5573896
AALB109421342 109432570
CQUCpipJ_CPIJ003456
CPII120419666
CNS116346306
SOC105195412
MPHA105838404
AEC105151023
ACEP105619788
PBAR105424989
VEM105566523
CFO105250801
FEX115237203
NVI100123613
CSOL105362970
TPRE106660479
MDL103575239
CGLO123264328
FAS105267657
DAM107040184
AGIF122851816
CCIN107266172
NVL108565014
APLN108738723
PPYR116171766
OTU111422709 111422711
BMOR692784
BMAN114245860
MSEX115456267
DPLKGM_214269
BANY112058287
PMAC106714268
PPOT106099909
PXU106127743
PRAP110994260
ZCE119829197
HAW110371086
TNL113501006
SLIU111352624
OFU114355854
PXY105386323
BTAB109043127
HHAL106687253
NLU111055219
FOC113214317 113216932
CSEC111861757
FCD110846031
DPXDAPPUDRAFT_233847
DMK116916130
PVM113823704
PJA122244711 122244712 122260867
PCHN125046135 125046249
HAME121861661
PCLA123762554
PTRU123507136
EAF111718131
LSM121119799
CRG105344267
MYI110442106
PMAX117321933
MMER123550385 123556138
LAK106154707 106179546
NVE5502102
EPA110235296
ATEN116298613
ADF107344624
AMIL114976626
PDAM113668211
SPIS111329290
ATHAT2G26230
ALY9330632
CRB17894740
CSAT104700982 104750279
EUSEUTSA_v10021194mg
BRP103828734
BNA106357878 106452898
BOE106301645
RSZ108861971
THJ104801755 104804947 104823771
CPAP110814496
CIT102631080
CICCICLE_v10016037mg
PVY116105727 116111772
MINC123192500 123227169
TCC18586835
GRA105779785
GHI107927605 107943104
GAB108460823
DZI111296600
EGR104421156
GMX100037445(UR2) 547453(UR9)
GSJ114369476 114403422
PVUPHAVU_007G234300g
VRA106770791
VAR108326630
VUN114189624
CCAJ109815339
APRC113871129
MTRMTR_1g048370
CAM101500535(nodulin-35)
LJALj6g3v0143890.1(Lj6g3v0143890.1)
ADU107474240 107474983 107479189
AIP107625265 107625653
AHF112727467 112727863 112744064 112749077 112783692 112786132 112790539
LANG109336232 109359424
FVE101304417
RCN112189051 112189060
PPER18778286
PMUM103330981
PAVI110758511
PDUL117618742
MDM103418481 103438828
PXB103933611
ZJU107413131
MNT21395798
CSV101206975
CMO103489372
BHJ120081363
MCHA111018658
CMAX111467578 111482298
CMOS111449433 111458738
CPEP111792556 111801822
RCU8272393
JCU105649139
HBR110664227 110667476
MESC110625006
POP7491607
PEU105125425
PALZ118060109
JRE109002171
QSU111993769 112017931 112021353
QLO115984267
TWL119989287
VVI100232988
VRI117927573 117929383
SLY100037732
SPEN107002894
SOT102581180
CANN107851994
NTA107791874 107813779
NSY104211356
NTO104091371
NAU109212210
INI109147930
ITR116000078
SIND105161011
OEU111375160
EGT105977732
SSPL121749463 121792365
HAN110925667
ECAD122603156
LSV111916296
CCAV112524727
DCR108205953
CSIN114302288
BVG104907803
SOE110804304
CQI110723244 110737418
NNU104590108 104601391
MING122058293
TSS122642274
PSOM113313717 113323856
NCOL116252767
OSA4324793
DOSAOs01t0865100-01(Os01g0865100)
OBR102704100
BDI100845980
ATS109743862
TDC119269687 119277699
TAES100037659 123062701 123079860
SBI110433901
ZMA100274529
SITA101785812
SVS117858963
PVIR120673542 120708771
PHAI112895402
PDA103721005
EGU105032853 105034366
MUS103979093
DCT110092579 110114143
PEQ110022445
AOF109836810
ATR18444423
SMOSELMODRAFT_156451 SELMODRAFT_172716
PPP112291670
CRECHLRE_12g504950v5
VCNVOLCADRAFT_73602
CSLCOCSUDRAFT_52384
CVRCHLNCDRAFT_20118
BPGBathy08g04420
MISMICPUN_64532
GSLGasu_65630
CCPCHC_T00000418001
KLAKLLA0_E10935g
KMXKLMA_20057
LTHKLTH0H09262g
ZROZYRO0G09482g
TDLTDEL_0F02670(TDEL0F02670)
TGBHG536_0D04740
ZMKHG535_0B05580
PPAPAS_chr2-2_0279
DHADEHA2A07194g
PICPICST_40781(URO1)
PGUPGUG_02092
SPAASPAPADRAFT_136352
LELLELG_01182
CALCAALFM_C200180CA(CaO19.2114)
CTPCTRG_01093
COTCORT_0A12930
CDUCD36_15160
CTENCANTEDRAFT_116017
YLIYALI0F09251g
CLUCLUG_05509
CLUSA9F13_16g00825
CAURCJI97_005601
SLBAWJ20_2522
PKZC5L36_0B08050
BNNFOA43_000942
BBRXBRETT_003773
OPAHPODL_00339
NCRNCU07853
NTENEUTE1DRAFT62263(NEUTE1DRAFT_62263)
SMPSMAC_02127
PANPODANSg5539
TTTTHITE_2171067
MTMMYCTH_2315024
CTHRCTHT_0071370
MGRMGG_05283
PPEIPpBr36_03665
TMNUCRPA7_3858
SSCKSPSK_07787
FGRFGSG_04126
FPUFPSE_00146
FVRFVEG_10312
FOXFOXG_11511
NHENECHADRAFT_81764
TRETRIREDRAFT_76381
TRRM419DRAFT_24207
MAWMAC_01658
MAJMAA_02492
CMTCCM_09432
PLJVFPFJ_02363
VALVDBG_06639
VDAVDAG_05692
CFJCFIO01_08679
CHIGCH63R_01989
SAPOSAPIO_CDS2119
ELAUCREL1_184
PFYPFICI_05327
SSLSS1G_00106
BFUBCIN_03g06830
MBEMBM_07067
PSCOLY89DRAFT_688903
GLZGLAREA_06901
ANIAN9470.2
AFMAFUA_2G10520
ACTACLA_069530
NFINFIA_085890
AORAO090011000588
ANGANI_1_1150034(An03g02330) ANI_1_826024(An02g06030)
AFVAFLA_007981
ALUCAKAW2_21127A AKAW2_40206S
ACHEACHE_40565A
APUUAPUU_11005A
PCSPc22g20960
PDPPDIP_63940
TMFPMAA_047670
TRGTRUGW13939_07826
CIMCIMG_04344
CPWCPC735_073860
UREUREG_01592
PBLPAAG_01437
PBNPADG_00331
ABEARB_05777
TVETRV_04465
AJEHCAG_08071
BGHBDBG_07100
PNOSNOG_08332
PTEPTT_12595
BZECOCCADRAFT_86661
BSCCOCSADRAFT_124032
BORCOCMIDRAFT_82479
AALTCC77DRAFT_1017270
ZTRMYCGRDRAFT_70045
PFJMYCFIDRAFT_184206
FFUCLAFUR5_09863
BCOMBAUCODRAFT_114390
NPAUCRNP2_5250
TMLGSTUM_00004503001
SPOSPCC1223.09
CNECNI02420
CNBCNBH2300
CNGCNAG_04307
CGICGB_H3440W
TMSTREMEDRAFT_70604
TASAA1Q1_03024
TVSTRAVEDRAFT_156281
DSQDICSQDRAFT_145006 DICSQDRAFT_70560
PCOPHACADRAFT_251616
SHSSTEHIDRAFT_117903
HIRHETIRDRAFT_439423
PSQPUNSTDRAFT_91772
ADLAURDEDRAFT_59877
FMEFOMMEDRAFT_102646
GTRGLOTRDRAFT_62332
LBCLACBIDRAFT_190858
MPRMPER_10554
MRRMoror_16610
MOREE1B28_005762
CCICC1G_04058
ABPAGABI1DRAFT42333(AGABI1DRAFT_42333)
ABVAGABI2DRAFT65743(AGABI2DRAFT_65743)
CPUTCONPUDRAFT_118951
SLASERLADRAFT_356374
WSEWALSEDRAFT_59270
WICJ056_002062
UMAUMAG_00672
PFPPFL1_00057
PGRPGTG_04959
MLRMELLADRAFT_39009
DDIDDB_G0286427(uox)
DPPDICPUDRAFT_49836
DFADFA_04065(uox)
ACANACA1_220120
PTIPHATRDRAFT_29736
PIFPITG_18435 PITG_18437
PSOJPHYSODRAFT_469313 PHYSODRAFT_477479
SPARSPRG_09685
GTTGUITHDRAFT_161824
NGRNAEGRDRAFT_80401
SCLsce4023
SCUSCE1572_24240
SMESM_b21284
NENNCHU2750_43570(uaZ)
BQBJ4P68_0017380(pucL)
RBKE0H22_18805(pucL)
VGOGJW-30_1_02473(uox)
TRBHB776_14910(pucL)
SNOSnov_3388
STARG3545_19125(pucL)
ANCGBB76_11060(pucL)
APRAG3A50_10785(pucL)
APOLK9D25_07670(pucL)
MRDMrad2831_0199
METM446_5249
MNOMnod_5813
MORMOC_0208(pucL)
MAQUMaq22A_1p31805
MPHYMCBMB27_05183
MEEDA075_04800(pucL)
METXA3862_01265
METSDK389_23800(pucL)
METIDK427_21980(pucL)
MMESMMSR116_07040(pucL)
MTEADK419_18885(pucL)
MINDmvi_57850
MOGMMB17_23025(pucL)
BBARRHAL1_01325
PSINCAK95_13210
LIZLGH83_16080(pucL)
BSUBSU32450(pucL)
BSRI33_3345(pucL)
BSLA7A1_2459
BSHBSU6051_32450(pucL)
BSYI653_15640
BSUTBSUB_03463(pucL)
BSULBSUA_03463(pucL)
BSUSQ433_17750
BSOBSNT_09727(pucL)
BSNBSn5_07115
BSQB657_32450(pucL)
BSXC663_3103(pucL)
BSPU712_16180
BSSBSUW23_15825(pucL)
BSTGYO_3538(pucL)
BSIACWD84_04465
BHTDIC78_14975
BMOJHC660_31270(pucL)
BTEQG4P54_16535(pucL)
BIQAN935_16280
BJSMY9_3258
BACIB1NLA3E_12615
BACYQF06_14540
BACLBS34A_35410(pucL)
BALMBsLM_3241
BSMBSM4216_2147
BACSAUL54_14940
BITBIS30_05785
BCABEFK13_16635(pucL)
BRYM0696_16330(pucL)
BEOBEH_09915
BFXBC359_11590
BHABH0759
BCLABC3735
BGIBGM20_10325
GGHGHH_c21820(pucL)
GEAGARCT_02054(uao)
PCALBV455_03585(uao)
BMURABE28_003430
PFRIL8956_22270(pucL)
SCIAHUG15_17705(pucL)
MEKUHUW50_12970(pucL)
BBEVBBEV_2689(uao)
BSEBsel_0582
PJDPjdr2_3315
PMSKNP414_03236(uao)
PMQPM3016_3460
PMWB2K_17880
PODPODO_06605
PAEFR50345_07070
PAEJH70737_06880
PNPIJ22_16630
PXLBS614_20795
PYGAWM70_00910
PSWUSY83_16740
PCXLPB68_13750
PPSCEHS13_20750(pucL)
PALBEJC50_19205(pucL)
PRZGZH47_00525(pucL)
PLYCGXP70_15750(pucL)
BTSBtus_2019
KPULGXN76_09800(pucL)
KEBGXN75_10260(pucL)
MGOAFA91_32355
MDXBTO20_17345
MGROFZ046_12950(pucL)
MKRMKOR_07400
MSPGF6B93_21710(pucL)
MSMMSMEG_1296
MSGMSMEI_1258
MSBLJ00_06455
MSNLI99_06455
MSHLI98_06455
MMAGMMAD_14320
MARZMARA_24760
MAUBMAUB_52830
MMUCC1S78_010080(pucL)
MMATMMAGJ_63580
MBOKMBOE_38490
MSEIMSEDJ_03270
MABMAB_2929c
MMVMYCMA_1623
MABBMASS_2864
MABLMMASJCM_2938
MCHEBB28_14755
MIZBAB75_15845
MSTEMSTE_02898
MSAOMYCSP_13255
MSALDSM43276_02713(uox)
ASDAS9A_4198
MPAKMIU77_08040(pucL)
CCYCSCMU_33800
NFANFA_52420
NFRERS450000_04639(uox)
NBRO3I_016180 O3I_039235
NSLBOX37_30035
NSRNS506_06726
NTPCRH09_09400(pucL) CRH09_28995(pucL)
NOZDMB37_18055(pucL) DMB37_37640(pucL)
NODFOH10_19465(pucL) FOH10_19505(pucL) FOH10_22330(pucL)
NAHF5544_19135(pucL) F5544_19190(pucL) F5544_41710(pucL)
NADNCTC11293_00174(uox)
NWLNWFMUON74_18950 NWFMUON74_55710
NIEKV110_18175(pucL) KV110_38435(pucL)
NTCKHQ06_14250(pucL) KHQ06_34870(pucL)
NHUH0264_26720(pucL) H0264_26810(pucL) H0264_33950(pucL)
NYALTV02_07860(pucL) LTV02_39005(pucL)
NGPLTT66_09200(pucL)
RHARHA1_ro01568 RHA1_ro04509
RERRER_21140
REYO5Y_10090
REBXU06_10315
RQIC1M55_10755(pucL)
ROPROP_12690 ROP_44290
ROAPd630_LPD00958 Pd630_LPD05707
RPYY013_22670
RBYCEJ39_08885(pucL)
RHBNY08_1727 NY08_3502
RAVAAT18_25545
RFAA3L23_00088(uox)
RHSA3Q41_03326(uox)
RHQIM25_12100
RHODAOT96_20935
RRT4535765_01297(uox)
RCRNCTC10994_02749(uox)
RTMG4H71_07535(pucL)
RKOJWS14_08055(pucL) JWS14_24360(pucL)
RGOKYT97_07985(pucL)
GAMGII34_19405(pucL)
TSMASU32_07280
SCOSCO6211(SC2G5.32)
SALBXNR_0633
SMASAVERM_2018(pucL)
SGRSGR_1309
SGBWQO_28725
SCBSCAB_18521
SSXSACTE_5453
SVLStrvi_2410
SHYSHJG_7271
SHOSHJGH_7031
SRCM271_13630
SMALSMALA_6025
SSOII1A49_33990(pucL)
SCTSCAT_4779
SCYSCATT_47730
SFASfla_1052
SBHSBI_02950
SVESVEN_2512 SVEN_6093
SDVBN159_2098(uox)
SALSSLNWT_0615
STRPF750_5793
SFISFUL_6171
SCIB446_29175
SALUDC74_6400
SALLSAZ_32150
SLVSLIV_07080
SGUSGLAU_26725
SVTSVTN_13450 SVTN_30295
STREGZL_02614
SCWTU94_26730
SLDT261_1848
SLCSL103_25185
SXISXIM_47140
STRMM444_18340 M444_27195
STRCAA958_28425
SAMBSAM23877_5951(uox)
SPRISPRI_1552
SCZABE83_05550
SCXAS200_11350
SRWTUE45_06834(uox)
STRFASR50_28400
SLEsle_14680(sle_14680)
SPAVSpa2297_26325
STRTA8713_25925
SCLFBB341_03990
SGSAVL59_12990
STSIA4E84_32100
SKYD0C37_04465(pucL)
SALWCP975_29065(pucL)
SGMGCM10017557_15640
SCADDN051_10065(pucL)
SLSSLINC_6745
SNRSNOUR_11160
SPLULK06_027275
STRDNI25_08290
SNWBBN63_05825
SAUOBV401_33935
SSIAA7J05_07840
SVUB1H20_29460
SPUNBFF78_10110
SGVB1H19_31945
SLAUSLA_6161
SALFSMD44_06844
SALJSMD11_1431
SLXSLAV_08750(uox1) SLAV_19850(uox2)
STROSTRMOE7_30430
SFKKY5_6544
SNZDC008_27920(pucL)
SGEDWG14_01832(uox)
SRJSRO_1626
SLKSLUN_31845(pucL)
SDXC4B68_08275(pucL)
SGDELQ87_07305(pucL)
SQZFQU76_27825(pucL)
SCYAEJ357_37535(pucL)
SASTCD934_05370(pucL)
STIRDDW44_25770(pucL)
SKACP970_08370(pucL)
SGZC0216_00835(pucL) C0216_09630(pucL)
SVNCP980_06850(pucL) CP980_16355(pucL)
SNKCP967_04940(pucL)
SHAWCEB94_32780(pucL)
SRKFGW37_00665 FGW37_25900(pucL)
SFICEIZ62_05855(pucL)
SGALCP966_29230(pucL)
SSPODDQ41_27250(pucL)
SVRCP971_05920(pucL)
SPADDVK44_29130(pucL)
SFYGFH48_10320(pucL)
SAQUEJC51_37370(pucL)
SGFHEP81_01812(pucL)
SCAVCVT27_28220(pucL)
SSEOD0Z67_23530(pucL)
SBYH7H31_05850(pucL)
SRIMCP984_07770(pucL)
SSUBCP968_07340(pucL) CP968_16230(pucL)
SPHVF9278_39005(pucL)
SCINCP977_12085(pucL) CP977_27595(pucL)
SFUGCNQ36_26555(pucL)
SPACB1H29_07330
STSUB7R87_28210
SCHACP983_08880(pucL)
SGXH4W23_14535(pucL) H4W23_31460(pucL)
SCOECP976_34700(pucL)
SBATG4Z16_05235(pucL)
SSPBCP982_32520(pucL)
SNFJYK04_04550(uox_1) JYK04_06648(uox_2)
SPLACP981_30710(pucL)
SBROGQF42_33475(pucL)
STUIGCM10017668_57370
SATAC5746_33465(pucL)
SCHFIPT68_29600(pucL)
SHUNDWB77_01706(uox)
SHARHUT13_23620(pucL)
SCYGS1361_31105(uox)
SFEUIM697_31620(pucL)
SLIAHA039_06290(pucL)
SDWK7C20_29340(pucL)
SVDCP969_30170(pucL)
SCALI6J39_29300(pucL)
SAUHSU9_028245(pucL)
SMOBJ7W19_25710(pucL)
SPRACP972_28745(pucL)
SPEUCGZ69_29805(pucL)
SROIIAG44_08030(pucL)
SXNIAG42_07000(pucL) IAG42_33225(pucL)
SGJIAG43_26550(pucL)
SHKJ2N69_30500(pucL)
SANUK7396_07820(pucL)
STRYEQG64_29500(pucL)
SDDD9753_06965(pucL)
SACTDMT42_30625(pucL)
SMAOCAG99_03235
SGOBtest1122_22950(pucL)
SINEKI385_35295(pucL)
SLFJEQ17_11085(pucL)
SDECL3078_37050(pucL)
KSKKSE_63370
KABB7C62_30590
KAUB6264_01120
KITCFP65_6316
STRIC7M71_005125(pucL)
LXLKDY119_03106
PSICJ4E96_12620(pucL)
CMCCMN_00267
MIOAOA12_01320
MCWA8L33_04275
MLVCVS47_02416(uox)
MCHNHCR76_11440(pucL)
MRNK8F61_18255(pucL)
RTNA6122_1518
RRYC1O28_06925(pucL)
RIAC7V51_05370(pucL)
RFSC1I64_04450(pucL)
RTEGSU10_08445(pucL)
CUMNI26_12225
CUBBJK06_04275
CUGC1N91_12385(pucL)
FRPAX769_03080
AGYATC03_05300
AGMDCE93_10615(pucL)
AMAUDSM26151_07360(uox)
ASOIMTP13_00050(pucL)
CARTPA27867_1468
CRYB7495_07110(pucL)
CPHYB5808_11810
HUMDVJ78_09150(pucL)
GRYD7I44_02135(pucL) D7I44_04275(pucL)
MANTBHD05_06545
HEAHL652_10655(pucL)
FRNF1C15_05910(pucL)
GLNF1C58_03565(pucL)
AGXAGREI_1041(uox)
SUBTKPL76_08265(pucL)
ARTArth_3427
ARRARUE_c35390(uox)
ARLAFL94_16680
AREAL755_03375
ARWMB46_14750
ARYATC04_01015
ARZAUT26_16280
ARUASPU41_03895
ARQBWQ92_13885
ARNCGK93_19080(pucL)
ARXARZXY2_326
ACRYAC20117_05940
ARTHC3B78_16720(pucL)
AJGKKR91_16125(pucL)
ASUNKG104_17015(pucL)
AAUAAur_3402
PUEFV140_18025(pucL)
PNVJMY29_16285(pucL)
ACHAchl_3208
APNAsphe3_33450
PSULAU252_13710
PSNINIBR502771_08300(pucL)
PSEYGU243_13025(pucL)
AAIAARI_33710
GARAOZ07_17635
GCRGcLGCM259_2798
GLUF0M17_16430(pucL)
GPRJQN66_17120(pucL)
KRHKRH_19780
KFVAS188_04945
KRSEQG70_15655(pucL)
KVRCIB50_0001106(uox)
SATKSA2016_3345
PAEYKUF55_18075(pucL)
BFABfae_08250
BRVCFK39_12195(pucL)
BRZCFK38_15305(pucL)
BRRC1N80_00895(pucL)
LMOIVV02_25695
YIMJ5M86_13145(pucL)
ALXLVQ62_04540(pucL)
CETB8281_09725
CCEUCBR64_01400
CFLCfla_2783
PSEIGCE65_05025(pucL)
SERJSGUI_2186
ORNDV701_17990(pucL)
ORZFNH13_01510(pucL)
BLYA2T55_04520
BLINBLSMQ_0835
BLUTEW640_09275(pucL)
BCAUI6G59_07265(pucL)
GYUFE374_12735(pucL)
MPHMLP_22140
NCANoca_1142
NOYEXE57_07460(pucL)
NSNEXE58_12285(pucL)
NANOG5V58_13160(pucL)
NAROCFH99_02280(pucL)
NCQK6T13_03965(pucL)
AERAERYTH_00570
MUZH4N58_17085(pucL)
KQIF1D05_01410(pucL)
NDANdas_0718
NALB005_3625(pucL)
NGVCDO52_20165(pucL)
SAIUJ4H86_24115(pucL)
ACTWF7P10_32560(pucL)
AGRAAGRA3207_006116(pucL)
SROSros_2773
NOABKM31_28615
NOWGBF35_17930(pucL)
NCXNocox_14920(uox)
NGNLCN96_17925(pucL)
TBITbis_2592
FRAFrancci3_1910
FREFranean1_2243
FRIFraEuI1c_4801
FALFRAAL4508
FSYFsymDg_1782
NMLNamu_0238 Namu_0250
GOBGobs_2838
MMARMODMU_0113(uox)
KRAKrad_2071
SENSACE_6736
SACGFDZ84_08590(pucL)
AMDAMED_1926
AMNRAM_09770
AMMAMES_1910
AMZB737_1912
AOIAORI_5946
AJAAJAP_09695(uox)
AMQAMETH_1603
AMYCCU254_07830(pucL) CU254_30640(pucL)
AMYBBKN51_23245
AABA4R43_06035 A4R43_18575
AMYYYIM_11225(uox1) YIM_19285(uox2)
AORISD37_29145
AACDLWP59_08070(pucL)
PDXPsed_1766
PSEAWY02_01130
PSEEFRP1_13340
PSEHXF36_13125
PSEQAD006_21020
PECQAD017_00600
PHHAFB00_24820
PBROHOP40_08910(pucL) HOP40_22150(pucL)
APRECNX65_29160(pucL)
AMIAmir_5939
SESPBN6_71160(uox)
SSYIEKG83_39890(pucL)
KALKALB_4480
KPHYAOZ06_19875
LEDBBK82_21895
ALOCRK55966
PMADBAY61_06850
SACEGIY23_11935(pucL)
MCABHXZ27_12115(pucL)
AMSAMIS_63790
ACTNL083_6156
AFSAFR_31535
AIHAiant_23910
PLABC6361_23935(pucL)
PLATC6W10_32815(pucL)
PFLAPflav_051020
PSUUPsuf_008750
ATLAthai_18200
ASERAsera_56240
CATICS0771_69290
DVCDvina_12145(pucL)
CCAZCOUCH_12645(pucL)
CAICaci_4737
SNASnas_2538
AEYCDG81_19595(pucL)
JTLM6D93_19090(pucL)
RXYRxyl_2843
RRDRradSPS_1305
RUBGBA63_15660(pucL)
RMARGBA65_15320(pucL)
ERZER308_09430(pucL)
EUZDVS28_a3619
KBSEPA93_23380(pucL)
DRADR_1160
DGEDgeo_2601
DGODGo_PA0216
DPDDeipe_0078
DSWQR90_03870
DPUSU48_09955
DEINDAAJ005_13635(pucL)
DGADEGR_34670
DPHEHF33_16910(pucL)
TRATrad_1503
LUOHHL09_09775(pucL)
MFFMFFC18_06180(uox)
AAGGETAA8_33800(uox)
LPAVPLANPX_2074
PNDPla175_41560(uox)
AMOBHG15A2_03670(uox)
SACISinac_4646
PHMPSMK_30590
ACMAciX9_2872
GMAAciX8_0720
GRWFTO74_13545(pucL)
TSAAciPR4_3479
TRSTerro_0864
TALBFTW19_00715(pucL)
ABASACPOL_2451
ADINH7849_02395(pucL)
SUSAcid_0359
ABACLuPra_02263(pucL_1)
CPICpin_6768
CHIHGWR21_13205(pucL)
CFILMYF79_29545(pucL)
NKONiako_0442
SPIKEXU85_15930(pucL)
SPIBG8759_09020(pucL)
HYPA0257_17680
HYZAXW84_04225
HYJFHG12_10350(pucL)
HQIH9L05_03275(pucL)
HTSHMJ29_15970(pucL)
HJEHacjB3_16061
HAADMW046_18160(pucL)
NMONmlp_3624(pucL1)
HDOMUK72_06530(pucL)
HWCHqrw_2223(pucL1)
HVOHVO_B0300(pucL1)
HALEG3A49_07345(pucL)
HAQDU484_08165(pucL)
HAJDU500_08200(pucL)
HAEhalTADL_2613
NVRFEJ81_21285(pucL)
NOUNatoc_3147
 » show all
Reference
1  [PMID:13363909]
  Authors
HUDSON PB, LONDON M.
  Title
Purification and properties of solubilized uricase.
  Journal
Biochim Biophys Acta 21:290-8 (1956)
DOI:10.1016/0006-3002(56)90010-5
Reference
2  [PMID:13271340]
  Authors
MAHLER HR, HUBSCHER G, BAUM R.
  Title
Studies on uricase.  I.  Preparation, purification, and properties of a cuproprotein.
  Journal
J Biol Chem 216:625-41 (1955)
Reference
3  [PMID:13252004]
  Authors
ROBBINS KC, BARNETT EL, GRANT NH.
  Title
Partial pruficiation of procine liver uricase.
  Journal
J Biol Chem 216:27-35 (1955)
Reference
4  [PMID:9709003]
  Authors
Kahn K, Tipton PA.
  Title
Spectroscopic characterization of intermediates in the urate oxidase reaction.
  Journal
Biochemistry 37:11651-9 (1998)
DOI:10.1021/bi980446g
Reference
5  [PMID:9360612]
  Authors
Colloc'h N, el Hajji M, Bachet B, L'Hermite G, Schiltz M, Prange T, Castro B, Mornon JP
  Title
Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 A resolution.
  Journal
Nat Struct Biol 4:947-52 (1997)
DOI:10.1038/nsb1197-947
  Sequence
Reference
6  [PMID:12680763]
  Authors
Imhoff RD, Power NP, Borrok MJ, Tipton PA.
  Title
General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad.
  Journal
Biochemistry 42:4094-100 (2003)
DOI:10.1021/bi027377x
Other DBs
ExplorEnz - The Enzyme Database: 1.7.3.3
IUBMB Enzyme Nomenclature: 1.7.3.3
ExPASy - ENZYME nomenclature database: 1.7.3.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.3.3
BRENDA, the Enzyme Database: 1.7.3.3
CAS: 9002-12-4

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