KEGG   ENZYME: 1.7.6.1Help
Entry
EC 1.7.6.1                  Enzyme                                 

Name
nitrite dismutase;
Prolixin S;
Nitrophorin 7
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a nitrogenous group as acceptor
BRITE hierarchy
Sysname
nitrite:nitrite oxidoreductase
Reaction(IUBMB)
3 nitrite + 2 H+ = 2 nitric oxide + nitrate + H2O [RN:R09751]
Reaction(KEGG)
Substrate
nitrite [CPD:C00088];
H+ [CPD:C00080]
Product
nitric oxide [CPD:C00533];
nitrate [CPD:C00244];
H2O [CPD:C00001]
Comment
Contains ferriheme b. The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. Nitric oxide produced induces vasodilation after injection. Nitrophorins 2 and 4 can also catalyse this reaction.
History
EC 1.7.6.1 created 2011
Orthology
K22962  nitrite dismutase
Reference
1  [PMID:19655755]
  Authors
He C, Knipp M
  Title
Formation of nitric oxide from nitrite by the ferriheme b protein nitrophorin 7.
  Journal
J Am Chem Soc 131:12042-3 (2009)
DOI:10.1021/ja9040362
  Sequence
Reference
2  [PMID:20524697]
  Authors
He C, Ogata H, Knipp M
  Title
Formation of the complex of nitrite with the ferriheme b beta-barrel proteins nitrophorin 4 and nitrophorin 7.
  Journal
Biochemistry 49:5841-51 (2010)
DOI:10.1021/bi100324z
Other DBs
ExplorEnz - The Enzyme Database: 1.7.6.1
IUBMB Enzyme Nomenclature: 1.7.6.1
ExPASy - ENZYME nomenclature database: 1.7.6.1
BRENDA, the Enzyme Database: 1.7.6.1

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