KEGG   ENZYME: 1.8.1.6Help
Entry
EC 1.8.1.6                  Enzyme                                 

Name
cystine reductase;
cystine reductase (NADH);
NADH-dependent cystine reductase;
cystine reductase (NADH2);
NADH2:L-cystine oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-cysteine:NAD+ oxidoreductase
Reaction(IUBMB)
2 L-cysteine + NAD+ = L-cystine + NADH + H+ [RN:R00892]
Reaction(KEGG)
Substrate
L-cysteine [CPD:C00097];
NAD+ [CPD:C00003]
Product
L-cystine [CPD:C00491];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.8.1.6 created 1961 as EC 1.6.4.1, transferred 2002 to EC 1.8.1.6
Pathway
ec00270  Cysteine and methionine metabolism
Reference
1  [PMID:13174550]
  Authors
ROMANO AH, NICKERSON WJ.
  Title
Cystine reductase of pea seeds and yeasts.
  Journal
J Biol Chem 208:409-16 (1954)
Reference
2  [PMID:5436160]
  Authors
Carroll JE, Kosicki GW, Thibert RJ.
  Title
Alpha-substituted cystines as possible substrates for cystine reductase and L-amino acid oxidase.
  Journal
Biochim Biophys Acta 198:601-3 (1970)
DOI:10.1016/0005-2744(70)90137-3
Reference
3  [PMID:211119]
  Authors
Maresca B, Jacobson E, Medoff G, Kobayashi G.
  Title
Cystine reductase in the dimorphic fungus Histoplasma capsulatum.
  Journal
J Bacteriol 135:987-92 (1978)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.6
IUBMB Enzyme Nomenclature: 1.8.1.6
ExPASy - ENZYME nomenclature database: 1.8.1.6
BRENDA, the Enzyme Database: 1.8.1.6
CAS: 9029-18-9

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