KEGG   ENZYME: 1.8.4.2Help
Entry
EC 1.8.4.2                  Enzyme                                 

Name
protein-disulfide reductase (glutathione);
glutathione-insulin transhydrogenase;
insulin reductase;
reductase, protein disulfide (glutathione);
protein disulfide transhydrogenase;
glutathione-protein disulfide oxidoreductase;
protein disulfide reductase (glutathione);
GSH-insulin transhydrogenase;
protein-disulfide interchange enzyme;
protein-disulfide isomerase/oxidoreductase;
thiol:protein-disulfide oxidoreductase;
thiol-protein disulphide oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
glutathione:protein-disulfide oxidoreductase
Reaction(IUBMB)
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol [RN:R03915]
Reaction(KEGG)
R03915;
(other) R02824
Show
Substrate
glutathione [CPD:C00051];
protein disulfide [CPD:C02582]
Product
glutathione disulfide [CPD:C00127];
protein dithiol [CPD:C02315]
Comment
Reduces insulin and some other proteins.
History
EC 1.8.4.2 created 1965
Pathway
ec00480  Glutathione metabolism
Orthology
K05360  protein-disulfide reductase (glutathione)
Genes
HSA: 51060(TXNDC12)
PTR: 100610643(TXNDC12)
PPS: 100996005(TXNDC12)
GGO: 101134035(TXNDC12)
PON: 100451283(TXNDC12)
NLE: 105737527(TXNDC12)
MCC: 712891(TXNDC12)
MCF: 102121050(TXNDC12)
CSAB: 103224818(TXNDC12)
RRO: 104667843(TXNDC12)
RBB: 108531798(TXNDC12)
CJC: 100400300(TXNDC12)
SBQ: 101039421(TXNDC12)
MMU: 66073(Txndc12)
RNO: 298370(Txndc12)
CGE: 100753389(Txndc12)
NGI: 103730255(Txndc12)
HGL: 101714855(Txndc12)
CCAN: 109698160(Txndc12)
OCU: 103350186(TXNDC12)
TUP: 102497800(TXNDC12)
CFA: 609843(TXNDC12)
AML: 100481735(TXNDC12)
UMR: 103670719(TXNDC12)
ORO: 101386371(TXNDC12)
FCA: 101089631(TXNDC12)
PTG: 102956818(TXNDC12)
AJU: 106988188(TXNDC12)
BTA: 506991(TXNDC12)
BOM: 102276264(TXNDC12)
BIU: 109556305(TXNDC12)
PHD: 102328808
CHX: 102189539(TXNDC12)
OAS: 101113445(TXNDC12)
SSC: 100517534(TXNDC12)
CFR: 102511212(TXNDC12)
BACU: 103015400(TXNDC12)
LVE: 103070023(TXNDC12)
OOR: 101283919(TXNDC12)
ECB: 100062254(TXNDC12)
EPZ: 103556054(TXNDC12)
EAI: 106826060(TXNDC12)
MYB: 102252702(TXNDC12)
MYD: 102760942(TXNDC12)
HAI: 109372589(TXNDC12)
RSS: 109453251(TXNDC12)
PALE: 102881310
LAV: 100655830(TXNDC12)
TMU: 101359872
MDO: 103095270(TXNDC12)
SHR: 105750619(TXNDC12)
OAA: 100078583(TXNDC12)
GGA: 772208(TXNDC12)
MGP: 100541059(TXNDC12)
CJO: 107317647(TXNDC12)
APLA: 101799624(TXNDC12)
ACYG: 106033048(TXNDC12)
TGU: 100225061(TXNDC12)
GFR: 102041968(TXNDC12)
FAB: 101807031(TXNDC12)
PHI: 102103484(TXNDC12)
PMAJ: 107208050(TXNDC12)
CCW: 104695524(TXNDC12)
FPG: 101917720(TXNDC12)
FCH: 102059863(TXNDC12)
CLV: 102085011(TXNDC12)
EGZ: 104131497(TXNDC12)
AAM: 106491077(TXNDC12)
ASN: 102381430(TXNDC12)
AMJ: 102573479(TXNDC12)
PSS: 102446057(TXNDC12)
CMY: 102942750(TXNDC12)
CPIC: 101932560(TXNDC12)
ACS: 100562080(txndc12)
PVT: 110076174(TXNDC12)
PBI: 103066536(TXNDC12)
GJA: 107111061(TXNDC12)
XLA: 380448(txndc12.S) 495430(txndc12.L)
XTR: 100379783(txndc12)
NPR: 108783807(TXNDC12)
DRE: 324900(txndc12)
CCAR: 109094186(txndc12)
IPU: 108267860(txndc12)
AMEX: 103026714(txndc12)
TRU: 101067813(txndc12)
LCO: 104927482(txndc12)
NCC: 104957515(txndc12)
MZE: 101479452(txndc12)
OLA: 101170372(txndc12)
XMA: 102228365(txndc12)
PRET: 103479915(txndc12)
NFU: 107383523(txndc12)
CSEM: 103396690(txndc12)
LCF: 108884259(txndc12)
HCQ: 109507400(txndc12)
BPEC: 110174922(txndc12)
SASA: 100286440(txndc12)
ELS: 105031232(txndc12)
SFM: 108923831(txndc12)
LCM: 102357648(TXNDC12)
CMK: 103172677(txndc12)
CIN: 100185750
SPU: 586825
APLC: 110977703
SKO: 100377044
BTER: 110119393
SOC: 105198763
AEC: 105148753
ACEP: 105618674
PBAR: 105422055
HST: 105184875
CFO: 112638907
LHU: 105675269
PGC: 109856411
BMOR: 101738456
PMAC: 106721148
PRAP: 110997338
PXY: 105382641
ZNE: 110839067
FCD: 110852856
CEL: CELE_Y57A10A.23(txdc-12.1)
BMY: Bm1_43155
TSP: Tsp_10270
MYI: 110463281
OBI: 106868638
LAK: 106151803
 » show all
Taxonomy
Reference
1  [PMID:14031343]
  Authors
KATZEN HM, TIETZE F, STETTEN D Jr.
  Title
Further studies on the properties of hepatic glutathione-insulin transhydro-genase.
  Journal
J Biol Chem 238:1006-11 (1963)
Reference
2
  Authors
Kohnert, K.-D., Hahn, H.-J., Zuhlke, H., Schmidt, S. and Fiedler, H.
  Title
Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro.
  Journal
Biochim Biophys Acta 338:68-77 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.2
IUBMB Enzyme Nomenclature: 1.8.4.2
ExPASy - ENZYME nomenclature database: 1.8.4.2
BRENDA, the Enzyme Database: 1.8.4.2
CAS: 9082-53-5

DBGET integrated database retrieval system