KEGG   ENZYME: 1.8.7.2Help
Entry
EC 1.8.7.2                  Enzyme                                 

Name
ferredoxin:thioredoxin reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
ferredoxin:thioredoxin disulfide oxidoreductase
Reaction(IUBMB)
2 reduced ferredoxin + thioredoxin disulfide = 2 oxidized ferredoxin + thioredoxin + 2 H+ [RN:R09502]
Reaction(KEGG)
Substrate
reduced ferredoxin [CPD:C00138];
thioredoxin disulfide [CPD:C00343]
Product
oxidized ferredoxin [CPD:C00139];
thioredoxin [CPD:C00342];
H+ [CPD:C00080]
Comment
The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37
(sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction.
History
EC 1.8.7.2 created 2010
Orthology
K17892  ferredoxin-thioredoxin reductase catalytic chain
Genes
ATH: AT2G04700
ALY: ARALYDRAFT_899275
CRB: 17892001
CSAT: 104747147 104766506 104793886
EUS: EUTSA_v10005082mg EUTSA_v10027982mg
BRP: 103852659 103863950
BNA: 106390938 106446128
BOE: 106337594
THJ: 104805419 104822811
CIT: 102629397
TCC: 18600695
EGR: 104422586
GMX: 100499945 547937(FTRC)
VRA: 106774272
VAR: 108343942
CCAJ: 109788440
CAM: 101496700
LJA: Lj2g3v1020070.1(Lj2g3v1020070.1)
ADU: 107491410
AIP: 107643977
FVE: 101292498
PPER: 18783723
PMUM: 103329919
PAVI: 110754713
PXB: 103928451
ZJU: 107415398
CSV: 101207663
CMO: 103498045
MCHA: 111006611
RCU: 8280588
JCU: 105642171
HBR: 110653440
POP: 7496819
JRE: 108992882
VVI: 100245804
SLY: 101268336
SPEN: 107011641
SOT: 102579143(ftrbpot)
CANN: 107860601
NSY: 104215943
NTO: 104086082
OEU: 111383097
HAN: 110920670
DCR: 108210507
BVG: 104908591
NNU: 104607964
OSA: 4346508
DOSA: Os09t0249900-01(Os09g0249900)
OBR: 102706226
BDI: 100829821
ATS: 109756744(LOC109756744)
SBI: 8077319
ZMA: 542532(ftr1)
SITA: 101758781
PDA: 103713070
DCT: 110096632
PEQ: 110023061
AOF: 109835774
ATR: 18429770
MNG: MNEG_0557
OLU: OSTLU_18254(FTR)
APRO: F751_4672
CCP: CHC_1145(ftrB)
SYN: sll0554(ftrC)
SYZ: MYO_125420(ftrC)
SYY: SYNGTS_2516(ftrC)
SYT: SYNGTI_2515(ftrC)
SYS: SYNPCCN_2514(ftrC)
SYQ: SYNPCCP_2514(ftrC)
SYJ: D082_19790(ftrC)
SYW: SYNW0318(ftrC)
SYC: syc2357_c(ftrC)
SYG: sync_2484
SYR: SynRCC307_2019(ftrC)
SYX: SynWH7803_2151(ftrC)
SYP: SYNPCC7002_A1851(ftrC)
CYB: CYB_0813
SYNR: KR49_06960
SYND: KR52_04740
SYH: Syncc8109_2367(ftrC)
SYNW: SynWH8103_00349(ftrC)
TEL: tll0113(ftrC)
THN: NK55_09780(ftrC)
CYI: CBM981_3036(ftrC)
LET: O77CONTIG1_03959(ftrC)
HHG: XM38_052270(ftrC)
AMR: AM1_4031
MAR: MAE_51290(ftrC)
MPK: VL20_1699
CHON: NIES4102_33260(ftrC)
CYT: cce_3398(ftrC)
TER: Tery_1567
ARP: NIES39_A05620(ftrC)
ANA: alr4065(ftrC)
AVA: Ava_1641
NAZ: Aazo_4385
CALH: IJ00_13090
NSP: BMF81_04352(ftrC)
CTHE: Chro_0987
CEO: ETSB_1018(ftrC)
NDE: NIDE3565
NJA: NSJP_0414
 » show all
Taxonomy
Reference
1  [PMID:1910303]
  Authors
Buchanan BB
  Title
Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and  future development.
  Journal
Arch Biochem Biophys 288:1-9 (1991)
DOI:10.1016/0003-9861(91)90157-E
Reference
2  [PMID:7628465]
  Authors
Chow LP, Iwadate H, Yano K, Kamo M, Tsugita A, Gardet-Salvi L, Stritt-Etter AL, Schurmann P
  Title
Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster.
  Journal
Eur J Biochem 231:149-56 (1995)
DOI:10.1111/j.1432-1033.1995.0149f.x
  Sequence
Reference
3  [PMID:8784198]
  Authors
Staples CR, Ameyibor E, Fu W, Gardet-Salvi L, Stritt-Etter AL, Schurmann P, Knaff DB, Johnson MK
  Title
The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters.
  Journal
Biochemistry 35:11425-34 (1996)
DOI:10.1021/bi961007p
Other DBs
ExplorEnz - The Enzyme Database: 1.8.7.2
IUBMB Enzyme Nomenclature: 1.8.7.2
ExPASy - ENZYME nomenclature database: 1.8.7.2
BRENDA, the Enzyme Database: 1.8.7.2

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