KEGG   ENZYME: 1.8.98.1Help
Entry
EC 1.8.98.1                 Enzyme                                 

Name
dihydromethanophenazine:CoB-CoM heterodisulfide reductase;
hdrDE (gene names);
CoB---CoM heterodisulfide reductase (ambiguous);
heterodisulfide reductase (ambiguous);
coenzyme B:coenzyme M:methanophenazine oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
CoB:CoM:methanophenazine oxidoreductase
Reaction(IUBMB)
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine [RN:R04540]
Reaction(KEGG)
Substrate
CoB [CPD:C04628];
CoM [CPD:C03576];
methanophenazine [CPD:C11903]
Product
CoM-S-S-CoB [CPD:C04832];
dihydromethanophenazine [CPD:C11904]
Comment
This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
History
EC 1.8.98.1 created 2003, modified 2017
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08264  heterodisulfide reductase subunit D
K08265  heterodisulfide reductase subunit E
Genes
DTO: TOL2_C26590
DTI: Desti_0745 Desti_5348 Desti_5359
DDH: Desde_0778
DOR: Desor_4327
AAB: A4R43_03725
AFG: AFULGI_00005160
AST: Asulf_01639
GAC: GACE_1903
GAH: GAH_00753
TAR: TALC_01537
MEAR: Mpt1_c14100(hdrD2)
MARC: AR505_0040
MAC: MA_0687(hdrE) MA_0688(hdrD)
MMA: MM_1843(hdrE) MM_1844(hdrD)
MCJ: MCON_3441(hdrE) MCON_3442(hdrD)
BARC: AOA65_0539(hdrD_2) AOA65_0555(hdrD_3) AOA65_2237(hdrD_5)
BARB: AOA66_1745(hdrD_3) AOA66_1757(hdrD_4)
LOKI: Lokiarch_00520(hdrD_1) Lokiarch_07600(hdrD_4) Lokiarch_10620(hdrD_5) Lokiarch_23520(hdrD_7) Lokiarch_40880(hdrD_11)
 » show all
Taxonomy
Reference
1  [PMID:2121478]
  Authors
Hedderich R, Berkessel A, Thauer RK.
  Title
Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg).
  Journal
Eur J Biochem 193:255-61 (1990)
DOI:10.1111/j.1432-1033.1990.tb19331.x
Reference
2  [PMID:9555882]
  Authors
Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U.
  Title
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1.
  Journal
J Bacteriol 180:2027-32 (1998)
Reference
3  [PMID:9665708]
  Authors
Simianu M, Murakami E, Brewer JM, Ragsdale SW.
  Title
Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila.
  Journal
Biochemistry 37:10027-39 (1998)
DOI:10.1021/bi9726483
Reference
4  [PMID:11034998]
  Authors
Murakami E, Deppenmeier U, Ragsdale SW.
  Title
Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila.
  Journal
J Biol Chem 276:2432-9 (2001)
DOI:10.1074/jbc.M004809200
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.1
IUBMB Enzyme Nomenclature: 1.8.98.1
ExPASy - ENZYME nomenclature database: 1.8.98.1
BRENDA, the Enzyme Database: 1.8.98.1

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