KEGG   ENZYME: 2.1.1.117Help
Entry
EC 2.1.1.117                Enzyme                                 

Name
(S)-scoulerine 9-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN:R03835]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-scoulerine [CPD:C02106]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-tetrahydrocolumbamine [CPD:C04118]
Comment
The product of this reaction is a precursor for protoberberine alkaloids in plants
History
EC 2.1.1.117 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13397  (S)-scoulerine 9-O-methyltransferase
Genes
PMUM: 103325170
MDM: 103435029
PXB: 103951351 103966079
VVI: 100265214
NNU: 104586605
Taxonomy
Reference
1  [PMID:24253642]
  Authors
Muemmler S, Rueffer M, Nagakura N, Zenk MH
  Title
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis.
  Journal
Plant Cell Rep 4:36-9 (1985)
DOI:10.1007/BF00285501
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.117
IUBMB Enzyme Nomenclature: 2.1.1.117
ExPASy - ENZYME nomenclature database: 2.1.1.117
BRENDA, the Enzyme Database: 2.1.1.117
CAS: 96380-65-3

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