KEGG   ENZYME: 2.1.1.120Help
Entry
EC 2.1.1.120                Enzyme                                 

Name
12-hydroxydihydrochelirubine 12-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine [RN:R04705]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
12-hydroxydihydrochelirubine [CPD:C05193]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dihydromacarpine [CPD:C05316]
Comment
This reaction is part of the pathway for synthesis of benzophenanthridine alkaloid macarpine in plants.
History
EC 2.1.1.120 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Kammerer, L., De-Eknamkul, W. and Zenk, M.H.
  Title
Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum.
  Journal
Phytochemistry 36:1409-1416 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.120
IUBMB Enzyme Nomenclature: 2.1.1.120
ExPASy - ENZYME nomenclature database: 2.1.1.120
BRENDA, the Enzyme Database: 2.1.1.120
CAS: 158736-40-4

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