KEGG   ENZYME: 2.1.1.137Help
Entry
EC 2.1.1.137                Enzyme                                 

Name
arsenite methyltransferase;
S-adenosyl-L-methionine:arsenic(III) methyltransferase;
S-adenosyl-L-methionine:methylarsonite As-methyltransferase;
methylarsonite methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:arsenite As-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate [RN:R05755];
(2) S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate [RN:R05756]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
arsenite [CPD:C06697];
methylarsonite [CPD:C07295]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylarsonate [CPD:C07294];
dimethylarsinate [CPD:C07308]
Comment
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by EC 1.20.4.2, methylarsonate reductase, to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate for this enzyme (EC 2.1.1.137), which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.
History
EC 2.1.1.137 created 2000, (EC 2.1.1.138 incorporated 2003), modified 2003
Orthology
K07755  arsenite methyltransferase
Genes
HSA: 57412(AS3MT)
PTR: 450703(AS3MT)
PPS: 100990214(AS3MT)
GGO: 101153169(AS3MT)
PON: 100450997(AS3MT)
NLE: 100599978(AS3MT)
MCC: 714122(AS3MT)
MCF: 102134286(AS3MT)
CSAB: 103216446(AS3MT)
RRO: 104656532(AS3MT)
RBB: 108515080(AS3MT) 108523719
CJC: 100396953(AS3MT)
SBQ: 101044998(AS3MT)
MMU: 57344(As3mt)
RNO: 140925(As3mt)
CGE: 100758973(As3mt)
NGI: 103744032(As3mt)
CCAN: 109691338(As3mt)
OCU: 100341970(AS3MT)
TUP: 102472983(AS3MT)
CFA: 486865(AS3MT)
AML: 100477280(AS3MT)
UMR: 103681866(AS3MT)
ORO: 101385200(AS3MT)
FCA: 101085409(AS3MT)
PTG: 102967021(AS3MT)
AJU: 106966953(AS3MT)
BTA: 505482(AS3MT)
BOM: 102269963(AS3MT)
BIU: 109579076(AS3MT)
PHD: 102327712(AS3MT)
CHX: 100861071(AS3MT)
OAS: 101115498(AS3MT)
SSC: 100622012(AS3MT)
CFR: 102508617(AS3MT)
CDK: 105095021(AS3MT)
BACU: 103007103(AS3MT)
LVE: 103071271(AS3MT)
OOR: 101274407(AS3MT)
ECB: 100069819(AS3MT)
EPZ: 103557886(AS3MT)
EAI: 106838170(AS3MT)
HAI: 109379613(AS3MT)
PALE: 102884356(AS3MT)
LAV: 100655067(AS3MT)
TMU: 101356087
OAA: 100080992(AS3MT)
GGA: 423870(AS3MT)
MGP: 100540487(AS3MT)
CJO: 107316092(AS3MT)
APLA: 106019053(AS3MT)
ACYG: 106031925(AS3MT)
TGU: 100231410(AS3MT)
GFR: 102037472(AS3MT)
FAB: 101821864(AS3MT)
PHI: 102102307(AS3MT)
PMAJ: 107206791(AS3MT)
CCAE: 111942873(AS3MT)
CCW: 104695520(AS3MT)
FPG: 101921972(AS3MT)
FCH: 102054327(AS3MT)
CLV: 102088931(AS3MT)
EGZ: 104125601(AS3MT)
AAM: 106494658(AS3MT)
ASN: 102372717(AS3MT)
AMJ: 102570140(AS3MT)
PSS: 102462506(AS3MT)
CMY: 102946003(AS3MT)
CPIC: 101933904(AS3MT)
ACS: 100559124(as3mt)
PVT: 110077626(AS3MT)
GJA: 107117927(AS3MT)
XLA: 100037130(as3mt.2.L) 108704944
XTR: 100145277 100216291(as3mt.1) 100492233(as3mt.2)
DRE: 664699(as3mt) 767695(zgc:153372)
IPU: 100528174(as3mt) 108278319
AMEX: 103041662 103046689(as3mt)
TRU: 101065150(as3mt)
LCO: 104921616(as3mt) 104922846
NCC: 104963176(as3mt)
MZE: 101473274(as3mt) 101478001
OLA: 101161375(as3mt) 101172512
XMA: 102228324(as3mt) 102231770
PRET: 103465085(as3mt) 103474544
NFU: 107380384 107395361(as3mt)
KMR: 108236292(as3mt) 108246026
CSEM: 103383999(as3mt)
LCF: 108875601(as3mt) 108890357
SDU: 111229289(as3mt) 111238018
MALB: 109957917(as3mt)
ELS: 105012235(as3mt)
SFM: 108932414 108933575(as3mt)
LCM: 102345342(AS3MT) 102352197
CMK: 103171735 103171996(as3mt)
APLC: 110985821
CRG: 105330173
ADF: 107348394
HMG: 100203411
AQU: 100636899
CRE: CHLREDRAFT_205859(COQ5E-3)
NTE: NEUTE1DRAFT148625(NEUTE1DRAFT_148625)
AAF: AURANDRAFT_78115(Met1)
XNE: XNC1_1511
XNM: XNC2_1471
PAR: Psyc_1156
GPS: C427_1516
SDE: Sde_3620
SAGA: M5M_04670
MAH: MEALZ_1383(As3mt)
TIG: THII_0119
NOC: Noc_0586
TGR: Tgr7_0251
HAZ: A9404_04350(arsM)
HCH: HCH_02988
HCO: LOKO_01812(rebM_1)
ABO: ABO_2182
ADI: B5T_00803
APAC: S7S_06185
AXE: P40_03785
SDF: ACG33_01220(arsM)
SLIM: SCL_2701
ENM: EBS_1045
RFR: Rfer_1612
MELA: C6568_16665(arsM)
OFO: BRW83_1231(ubiE_3)
RGE: RGE_20810
RBN: RBXJA2T_04893(arsM)
NET: Neut_0320
TBD: Tbd_1428
GCA: Galf_1904
SDR: SCD_n02152(arsM) SCD_n02256 SCD_n03102(arsM)
TCL: Tchl_2721
GME: Gmet_2791
GLO: Glov_0896
DDS: Ddes_1926
DMA: DMR_37290
DGG: DGI_1308
DRT: Dret_0953
DSF: UWK_01460
DOL: Dole_0762
SFU: Sfum_0266
BSED: DN745_03555(arsM)
PLA: Plav_2318
RPA: RPA3562
RPB: RPB_1968
RPD: RPD_3422
RPT: Rpal_4080
NHA: Nham_4641
MOR: MOC_2961
RVA: Rvan_3533
MCG: GL4_2446
SIL: SPO2690
PSF: PSE_2097
BLAS: BSY18_1846
ELI: ELI_00355
MAGQ: MGMAQ_1552
BACI: B1NLA3E_08755(arsM)
BBEV: BBEV_3082(ubiE-3)
GKA: GK0592
PTL: AOT13_12895(arsM)
LYB: C3943_15315(arsM) C3943_16600(arsM)
APAK: AP3564_14385(arsM)
GMO: NCTC11323_00339(ycgJ)
PPO: PPM_3099(arsM)
PPOY: RE92_17420(arsM)
PSAB: PSAB_12345(arsM)
PDU: PDUR_08150(arsM) PDUR_14075(arsM)
PBD: PBOR_32135(arsM)
PGM: PGRAT_28750(arsM)
PAEN: P40081_33570(arsM)
PAEQ: R50912_24560(arsM)
PSTE: PSTEL_14450(arsM)
PAEH: H70357_18645(arsM)
PDH: B9T62_03060(arsM)
PIB: BBD41_28675(arsM)
PCX: LPB68_10620(arsM)
PAIH: ASL14_15885(arsM)
CBA: CLB_0799
CBF: CLI_0840
CPAS: Clopa_0618
CPAT: CLPA_c05000(arsM)
CPAE: CPAST_c05000(arsM)
AMT: Amet_3267
AOE: Clos_1094
STH: STH2369
SLP: Slip_2179
DAE: Dtox_2552
PTH: PTH_0440
CTHM: CFE_1002
TPZ: Tph_c04450(arsM)
TOC: Toce_0607
TSH: Tsac_0926
PMIC: NW74_02025
PUF: UFO1_3913
PFT: JBW_03094
LPIL: LIP_0544
MHAD: B586_12150
SCO: SCO3452(SCE46.09c)
SHY: SHJG_8484
SLD: T261_3851
XCE: Xcel_3346
CFL: Cfla_3376
CFI: Celf_3648
MPH: MLP_37580
NCA: Noca_3743
PSIM: KR76_16865
MGG: MPLG2_0468(arsM)
NML: Namu_0104
AMN: RAM_03855
AMM: AMES_0754
AMZ: B737_0755
SNA: Snas_1723
RXY: Rxyl_2880
CWO: Cwoe_0591
AEQ: AEQU_0851
CTHE: Chro_2853
DET: DET1420
DEH: cbdbA1384
DMC: btf_1298
DMD: dcmb_1279
DMG: GY50_1258(arsM)
RCA: Rcas_2312
STI: Sthe_2038
OTE: Oter_1590
MIN: Minf_0141(smtA)
PLH: VT85_21590(ubiE_8)
IPA: Isop_2577
SACI: Sinac_4607
PBOR: BSF38_05796(eryG)
TPED: TPE_0353
SUS: Acid_4410
ABAC: LuPra_03085(ubiE_6) LuPra_04046(as3mt)
TAI: Taci_0499
GAU: GAU_0703
GBA: J421_2256
PMUC: ING2E5A_1787(arsM)
DORI: FH5T_14860
FLN: FLA_2992
MGOT: MgSA37_01199(ubiE_2)
FAE: FAES_5192
HSW: Hsw_0589
CTAK: 4412677_00482(ubiE_1) 4412677_00644(ubiE_2)
IAL: IALB_2688
MRO: MROS_1044
NDE: NIDE3709
NJA: NSJP_2692
LFC: LFE_1365
MFC: BRM9_2029
MCUB: MCBB_2274(arsM)
MEAR: Mpt1_c14370(arsM2)
MARC: AR505_0981
MAC: MA_3783
MBAR: MSBR2_2927
MBAK: MSBR3_0131
METM: MSMTP_0716
MTHE: MSTHC_0377
MHOR: MSHOH_0765
MMH: Mmah_1297
MPY: Mpsy_2039
MTP: Mthe_1429
MHI: Mhar_1545
MPI: Mpet_2814
MPD: MCP_0689
MEZ: Mtc_2327
HSL: OE_5444F(arsM)
HDL: HALDL1_07210(arsM)
NMO: Nmlp_2711(arsM)
HLA: Hlac_1246
HTU: Htur_3046
NEV: NTE_00056
TAA: NMY3_02003(ycgJ_2)
NDV: NDEV_0358
 » show all
Taxonomy
Reference
1  [PMID:10604879]
  Authors
Zakharyan RA, Aposhian HV.
  Title
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase.
  Journal
Chem Res Toxicol 12:1278-83 (1999)
DOI:10.1021/tx9901231
Reference
2  [PMID:10387927]
  Authors
Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes.
  Journal
Toxicol Appl Pharmacol 158:9-15 (1999)
DOI:10.1006/taap.1999.8687
Reference
3  [PMID:8806872]
  Authors
Zakharyan RA, Wildfang E, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic.
  Journal
Toxicol Appl Pharmacol 140:77-84 (1996)
DOI:10.1006/taap.1996.0199
Reference
4  [PMID:8605285]
  Authors
Zakharyan R, Wu Y, Bogdan GM, Aposhian HV.
  Title
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver.
  Journal
Chem Res Toxicol 8:1029-38 (1995)
Reference
5  [PMID:11790780]
  Authors
Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ.
  Title
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.
  Journal
J Biol Chem 277:10795-803 (2002)
DOI:10.1074/jbc.M110246200
  Sequence
[rno:140925]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.137
IUBMB Enzyme Nomenclature: 2.1.1.137
ExPASy - ENZYME nomenclature database: 2.1.1.137
UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.137
BRENDA, the Enzyme Database: 2.1.1.137
CAS: 167140-41-2

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