KEGG   ENZYME: 2.1.1.139Help
Entry
EC 2.1.1.139                Enzyme                                 

Name
3'-demethylstaurosporine O-methyltransferase;
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase;
staurosporine synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine [RN:R05757]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-demethylstaurosporine [CPD:C07349]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
staurosporine [CPD:C02079]
Comment
Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
History
EC 2.1.1.139 created 2000
Pathway
ec00404  Staurosporine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20082  O-methyltransferase StaMB
Genes
SRN: A4G23_00556(rebM_1)
SCLF: BB341_29640
SAQ: Sare_2332
Taxonomy
Reference
1  [PMID:9727395]
  Authors
Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zahner H.
  Title
3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine.
  Journal
J Antibiot (Tokyo) 51:679-82 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.139
IUBMB Enzyme Nomenclature: 2.1.1.139
ExPASy - ENZYME nomenclature database: 2.1.1.139
BRENDA, the Enzyme Database: 2.1.1.139
CAS: 212906-74-6

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