KEGG   ENZYME: 2.1.1.147Help
Entry
EC 2.1.1.147                Enzyme                                 

Name
corydaline synthase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+ [RN:R07241]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
palmatine [CPD:C05315];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
corydaline [CPD:C15530];
NADP+ [CPD:C00006]
Comment
Also acts on 7,8-dihydropalmatine.
History
EC 2.1.1.147 created 2002
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Rueffer, M., Bauer, W. and Zenk, M.H.
  Title
The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro.
  Journal
Canad J Chem 72:170-175 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.147
IUBMB Enzyme Nomenclature: 2.1.1.147
ExPASy - ENZYME nomenclature database: 2.1.1.147
BRENDA, the Enzyme Database: 2.1.1.147
CAS: 155807-67-3

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