KEGG   ENZYME: 2.1.1.152Help
Entry
EC 2.1.1.152                Enzyme                                 

Name
precorrin-6A synthase (deacetylating);
precorrin-6X synthase (deacetylating);
CobF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate [RN:R05219]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
precorrin 5 [CPD:C06416];
H2O [CPD:C00001]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
precorrin 6A [CPD:C06320];
acetate [CPD:C00033]
Comment
In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.
History
EC 2.1.1.152 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K02228  precorrin-6A synthase
Genes
FAU: Fraau_1604
PMY: Pmen_4583
PMK: MDS_4923
PPSE: BN5_4394(cobF)
PALC: A0T30_08895
PCQ: PcP3B5_15360(sumT_1)
PPU: PP_3763
PPF: Pput_2000
PPG: PputGB1_2140
PPW: PputW619_2104
PPT: PPS_3233
PPI: YSA_09357
PPX: T1E_3914(cobF)
PPUH: B479_16075
PPUT: L483_19690
PPUN: PP4_20250(cobF)
PPUD: DW66_3660
PMON: X969_15565
PMOT: X970_15210
PSB: Psyr_2442
PSYR: N018_15080
PFL: PFL_2249(cobF)
PPRC: PFLCHA0_c23110(cobF)
PPRO: PPC_2289(cobF)
PFS: PFLU_2445(cobF)
PFC: PflA506_2286(cobF)
PFW: PF1751_v1c21430(cobF)
PFB: VO64_5585
PMAN: OU5_5874
PEN: PSEEN3208
PPUU: PputUW4_03212(cobF)
PKC: PKB_1561(cobF)
PSES: PSCI_4761
PSEM: TO66_11290
PSEC: CCOS191_2416(cobF)
PSOS: POS17_2223(cobF)
PANR: A7J50_3325
PSIL: PMA3_17435
ACX: Achr_f700(cobF)
HEL: HELO_1841(cobF)
HAM: HALO2061
GPB: HDN1F_26350(cobF)
BGU: KS03_4726(cobF)
BGO: BM43_5144(cobF)
BFN: OI25_4709(cobF)
DAC: Daci_5843
CTES: O987_11725
RGE: RGE_19270(cobF)
MLO: mlr1461
SME: SMc03194(cobF)
SMX: SM11_chr3097(cobF)
SMI: BN406_02781(cobF)
SMEL: SM2011_c03194(cobF)
SMER: DU99_16115
SMD: Smed_2819
RHI: NGR_c29820(cobF)
SFH: SFHH103_02989(cobF)
SFD: USDA257_c53980(cobF)
SIX: BSY16_3268(cobF)
SAME: SAMCFNEI73_Ch3354(cobF)
EAD: OV14_0450(cobF)
ARA: Arad_9597(cobF)
RET: RHE_PE00456(cobF)
REC: RHECIAT_PA0000379(cobF)
REL: REMIM1_PD00479(cobF)
REP: IE4803_PA00415(cobF)
REI: IE4771_PC00428(cobF)
RLE: pRL110632(cobF)
RLG: Rleg_7173
RTR: RTCIAT899_PC06985(cobF)
RHL: LPU83_pLPU83d0188(cobF)
RGA: RGR602_PC01217(cobF)
RHN: AMJ98_PD00465(cobF)
RPHA: AMC79_PB00388(cobF)
RHX: AMK02_PE00472(cobF)
RHK: Kim5_PB00448(cobF)
SHZ: shn_19595
BJA: blr3275(cobF)
BRS: S23_47290(cobF)
BRAD: BF49_1423
BRK: CWS35_19655(cobF)
BOT: CIT37_37185(cobF)
RPA: RPA2097(cobF)
RPB: RPB_3174
RPC: RPC_1896
RPD: RPD_2326
RPE: RPE_2230
RPT: Rpal_2387
BOS: BSY19_866(cobF)
SNO: Snov_3866
MEX: Mext_3385
MEA: Mex_1p3613(cobF)
MDI: METDI4188(cobF)
MCH: Mchl_3694
MPO: Mpop_3576
MOR: MOC_1916(cobF)
META: Y590_16610
MSL: Msil_3231
HDN: Hden_3043
HMC: HYPMC_4271(cobF)
RVA: Rvan_2495
PHL: KKY_930
FIL: BN1229_v1_3164(cobF)
FIY: BN1229_v1_2758(cobF)
BVR: BVIR_732
SIL: SPO2874(cobF)
RSP: RSP_2819(cobF)
RCP: RCAP_rcc02038(cobF)
JAN: Jann_2920
RDE: RD1_3816(cobF)
RLI: RLO149_c006280(cobF)
PDE: Pden_2542
PAMN: JCM7685_0429(cobF)
PGD: Gal_02686
CID: P73_0481
MALG: MALG_01197
RSU: NHU_02589(cobF)
RHC: RGUI_1457
NAR: Saro_0332
SPHP: LH20_21900
STAX: MC45_16145
SJP: SJA_C2-03190(cobF)
SPMI: K663_18436
SPHB: EP837_03425(cobF)
SINB: SIDU_11790
SPHT: K426_22504
AMV: ACMV_P1_00520(cobF)
ASZ: ASN_3525(cobF)
RRU: Rru_A2970
RRF: F11_15215
MCE: MCAN_09451(cobF)
MCQ: BN44_11038(cobF)
MCV: BN43_20416(cobF)
MCX: BN42_20755(cobF)
MCZ: BN45_20247(cobF)
MPA: MAP_0888
MAO: MAP4_2972
MAVI: RC58_14755
MAVU: RE97_14780
MAV: MAV_1065(cobF)
MAVD: NF84_04635
MAVR: LA63_04735
MAVA: LA64_04750
MIT: OCO_09330
MIA: OCU_09370
MID: MIP_01553
MYO: OEM_09530
MIR: OCQ_09460
MMAL: CKJ54_04640(cobF)
MLP: MLM_1015
MUL: MUL_4422
MMC: Mmcs_4338
MKM: Mkms_4424
MJL: Mjls_4718
MMI: MMAR_4563
MMM: W7S_04625
MHAD: B586_06230
MSM: MSMEG_5548(cobF)
MVA: Mvan_0376
MGI: Mflv_0361
MPHL: MPHLCCUG_00906(cysG_1)
MVQ: MYVA_0347
MTHN: 4412656_03793(cobI_2)
MAB: MAB_1037
MABB: MASS_1032
MABO: NF82_05225
MCHE: BB28_05165
MSTE: MSTE_01008
ASD: AS9A_3591(cobF)
CDI: DIP0822
CDIP: ERS451417_00729(cobI)
CKP: ckrop_0458(cobF)
CPU: cpfrc_00630(cobF)
CPL: Cp3995_0640(cobF)
CPG: Cp316_0651(cobF)
CPP: CpP54B96_0640(cobF)
CPK: Cp1002_0629(cobF)
CPQ: CpC231_0629(cobF)
CPX: CpI19_0628(cobF)
CPZ: CpPAT10_0630(cobF)
COR: Cp267_0658(cobF)
COP: Cp31_0636(cobF)
COD: Cp106_0614(cobF)
COS: Cp4202_0623(cobF)
COI: CpCIP5297_0641(cobF)
COE: Cp258_0635(cobF)
COU: Cp162_0627(cobF)
CPSE: CPTA_01180
CPSU: CPTB_00352
CPSF: CPTC_01171
CUL: CULC22_00685(cobF)
CUC: CULC809_00673(cobF)
CUN: Cul210932_0709(cobF)
CUS: CulFRC11_0678(cobF)
CUQ: Cul210931_0677(cobF)
CUZ: Cul05146_0729(cobF)
CUJ: CUL131002_0686(cobF)
COA: DR71_626(cobF)
CKU: UL82_08555(cobF)
CEI: CEPID_03775(cobF)
CAQU: CAQU_00675
NFA: NFA_50210
NCY: NOCYR_4786(cobF)
NSR: NS506_01475(cobF)
RER: RER_44600(cobF)
REY: O5Y_20955
ROP: ROP_19610(cobF)
REQ: REQ_11090(cobF)
RHB: NY08_3904
RRT: 4535765_03937(cbiL)
GBR: Gbro_1321
GPO: GPOL_c38500(cobF)
GOR: KTR9_1234
TPR: Tpau_3353
SCO: SCO6971(SC6F7.24c)
SMA: SAVERM_1600(cobF)
SGR: SGR_1214
SGB: WQO_29245
SHY: SHJG_7698
SVE: SVEN_5566
SDV: BN159_1551(cobF)
SALB: XNR_5616
SALS: SLNWT_6775
SFI: SFUL_6267
SLV: SLIV_04395(cobF)
SGU: SGLAU_28590(cobF)
STRM: M444_06910
SAMB: SAM23877_6460(cobF)
SLE: sle_08880(sle_08880)
STRD: NI25_04350
SALF: SMD44_07530(cobF) SMD44_07531(cobF)
SFK: KY5_7945
LMOI: VV02_21350
PAC: PPA1920
PAK: HMPREF0675_4977(cobF)
PAW: PAZ_c20000(cobF)
PACC: PAC1_09815
PACH: PAGK_1835
CACN: RN83_09890
CGRN: 4412665_00095(cbiL)
MPH: MLP_03920(cobF)
NCA: Noca_2879
NDK: I601_3855
KFL: Kfla_5080
PSIM: KR76_17145
MGG: MPLG2_3517(cobF)
TFU: Tfu_0320
NDA: Ndas_1612
NAL: B005_0624(cobF)
FAL: FRAAL2802
NML: Namu_0142
AMD: AMED_6899(cobF)
AMN: RAM_35395
AMM: AMES_6793(cobF)
AMZ: B737_6793(cobF)
AOI: AORI_1819(cobF)
AJA: AJAP_30370(cobF)
PDX: Psed_2708
PSEA: WY02_07005
PSEE: FRP1_06980
PSEH: XF36_07800
AMI: Amir_4201
SESP: BN6_35150(cobF)
MIL: ML5_4315
ASE: ACPL_6895(cobF)
ACTN: L083_6529(cobF)
AFS: AFR_33965
ACTS: ACWT_6764
CAI: Caci_6988
TBI: Tbis_2504
ABAS: ACPOL_5058
CTHI: THC_0078
 » show all
Taxonomy
Reference
1  [PMID:8226690]
  Authors
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F.
  Title
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
  Journal
J Bacteriol 175:7430-40 (1993)
DOI:10.1128/JB.175.22.7430-7440.1993
Reference
2  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.152
IUBMB Enzyme Nomenclature: 2.1.1.152
ExPASy - ENZYME nomenclature database: 2.1.1.152
BRENDA, the Enzyme Database: 2.1.1.152

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