Entry |
|
Name |
glycine/sarcosine N-methyltransferase;
ApGSMT;
glycine-sarcosine methyltransferase;
GSMT;
GMT;
glycine sarcosine N-methyltransferase;
S-adenosyl-L-methionine:sarcosine N-methyltransferase
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Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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Sysname |
S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase [sarcosine(or N,N-dimethylglycine)-forming]
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Reaction(IUBMB) |
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction) [RN: R10060];
(1a) S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine [RN: R00367];
(1b) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine [RN: R07243]
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Reaction(KEGG) |
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Substrate |
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N,N-dimethylglycine [CPD: C01026];
sarcosine [CPD: C00213]
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Comment |
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase. Differs from EC 2.1.1.20, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction [3].
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History |
EC 2.1.1.156 created 2005
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Pathway |
ec00260 | Glycine, serine and threonine metabolism |
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Orthology |
K18896 | glycine/sarcosine N-methyltransferase |
K24071 | glycine/sarcosine/dimethylglycine N-methyltransferase |
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Genes |
» show all
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Reference |
|
Authors |
Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T |
Title |
Extreme halophiles synthesize betaine from glycine by methylation. |
Journal |
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Sequence |
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Reference |
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Authors |
Nyyssola A, Reinikainen T, Leisola M |
Title |
Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase. |
Journal |
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Sequence |
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Reference |
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Authors |
Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T |
Title |
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.156 |
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