KEGG   ENZYME: 2.1.1.156
Entry
EC 2.1.1.156                Enzyme                                 
Name
glycine/sarcosine N-methyltransferase;
ApGSMT;
glycine-sarcosine methyltransferase;
GSMT;
GMT;
glycine sarcosine N-methyltransferase;
S-adenosyl-L-methionine:sarcosine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase [sarcosine(or N,N-dimethylglycine)-forming]
Reaction(IUBMB)
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction) [RN:R10060];
(1a) S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine [RN:R00367];
(1b) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine [RN:R07243]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
glycine [CPD:C00037];
sarcosine [CPD:C00213]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N,N-dimethylglycine [CPD:C01026];
sarcosine [CPD:C00213]
Comment
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase. Differs from EC 2.1.1.20, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction [3].
History
EC 2.1.1.156 created 2005
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K18896  glycine/sarcosine N-methyltransferase
K24071  glycine/sarcosine/dimethylglycine N-methyltransferase
Genes
PFSPFLU_2095
PTVAA957_04385
PAZOAYR47_17170
PRXHRH33_10580
PFWPF1751_v1c19160
PFFPFLUOLIPICF727140
PFXA7318_08950
PGGFX982_02907
PTRTHU722_0010675
PASGKSS96_10195
PPEGKUA23_10290
SALHHMF8227_02086(gsmT)
TIGTHII_1900 THII_1901
TMBThimo_1798 Thimo_2027
MPURMARPU_03465
TEETel_06780
THIPN838_15840
THIMKFB96_17230
HHAHhal_1068 Hhal_1678
HHKHH1059_14700
HHCM911_05560 M911_09985
EBSECTOBSL9_2257 ECTOBSL9_2476
TGRTgr7_1181
TKMTK90_0179
TNITVNIR_0234
TTITHITH_16330
TVRTVD_00875
NAXHC341_02610
WEZIC757_03175
TTCFOKN1_2395
THICTspCOW1_02660
CSACsal_0742
SALNSALB1_0939
GPIGPICK_14290
MXAMXAN_7068
MSDMYSTI_07665
MFBMFUL124B02_40805
MFULILAB_11030
MMASMYMAC_006774
HOHHoch_6748
DTIDesti_0623
NIYFQ775_18170
PLAPlav_2856
KMNHW532_17805
FILBN1229_v1_3116
FIYBN1229_v1_2804
RBMTEF_00780
LAPACP90_08120
LABRCHH27_01290
LABTFIU93_13755
LAGGB0E33_20175
ACUTMRB58_00815
RIDRIdsm_00793
MALUKU6B_49030
GAKX907_0699
AAYWYH_00219
ELQGa0102493_112272
DEXHWD60_10300
MAGQMGMAQ_3234
BMYCDJ92_2202
BACIB1NLA3E_10510
LGYT479_12890
AIAAWH56_002290 AWH56_011610
BLENNCTC4824_00639(bsmA_1)
BSEBsel_2039
GYMGYMC10_4443
PTAHPL003_02090
PKBB4V02_04440
PLWD5F53_07935
PALBEJC50_03270
PRZGZH47_25465
PLYCGXP70_24705
BTSBtus_2799
KYRCVV65_14095
ERAFJ9537_05805
CCBClocel_0238
CLBClo1100_2910
CPATCLPA_c08290
CPAECPAST_c08290
CSBCLSA_c15300
CLTCM240_2839
AMTAmet_1179
AOEClos_0075
GFEGferi_22420
CRSFQB35_12120
SARJHH195_06415
CTHCthe_1959
CTXClo1313_2631
CCLClocl_0590
RUKA4V00_02515
CCECcel_1149
RHEREHE19_013920
CTHDCDO33_03510
ACACEYQ97_12180
RGNRGna_03215
DORDesor_3321
DMIDesmer_2586
DCADesca_2315
DRMDred_0699
DRUDesru_3318
DFGB0537_03950
TJRTherJR_2506
DGIDesgi_1963
ALKAJ0B03_04590
VGUHYG85_21085
VPYHZI73_02980 HZI73_15200
ACAEHYG86_16525
CTHMCFE_1976
NTHNther_0677
HALSD7D81_10650
SEDZJYG23_07960 JYG23_13585 JYG23_13600
MMIMMAR_0861
MMAEMMARE11_08120
MLIMULP_00886
MPSEMPSD_09890 MPSD_09910
MSHOMSHO_26200
MBAIMB901379_00735
MSPGF6B93_03465
MDUMDUV_36420
MPSCMPSYJ_29420
MPOFMPOR_13070
SSXSACTE_2205
SVLStrvi_1838
SHYSHJG_1835
SHOSHJGH_1600
SRCM271_16300
SMALSMALA_5460
SSOII1A49_30960
SALUDC74_857
SALLSAZ_04785
STREGZL_00112
SLSSLINC_0113
SNWBBN63_13005
SAUOBV401_31165
SVUB1H20_14640
SPUNBFF78_24230
SGVB1H19_33065
SALFSMD44_06865
SLXSLAV_39415(bsmA)
SCYAEJ357_01395
SNKCP967_29365
SCAVCVT27_28440
SSEOD0Z67_23820
SCOECP976_31035
SBATG4Z16_08455
SBROGQF42_42160
SLIAHA039_01805
SCALI6J39_14835
SGOBtest1122_02690
SINEKI385_35155
SAOVG3H79_06490
NPCKUV85_07820
NGVCDO52_05885
STRREKD16_20715
SAIUJ4H86_12575
ACTWF7P10_26560
SENSACE_3901 SACE_5862(gsmT)
SACGFDZ84_36205
SVISvir_27050
PAUTPdca_14800
KPHYAOZ06_46630
PMADBAY61_22795
SACEGIY23_10125
NHYJQS43_05010
SNASnas_2966
AEYCDG81_09050
ERZER308_18525
SYXSynWH7803_0361
SYNRKR49_11730
SYNWSynWH8103_02187(gbmt1)
DSLDacsa_3637
SYWSYNW1914(gsmt)
PMTPMT_0552
PMFP9303_17011
HHGXM38_033970
HAOPCC7418_3510
ENNFRE64_13775
ATMANT_00580
ABATCFX1CAM_1343
PSUBPelsub_P0507
AMUCPan181_00940
KSTKSMBR1_0462
PBUL21SP3_00981
PBPSTSP1_02231
ALUSSTSP2_01992
VBLL21SP4_02069
BHCJFL75_02925
CAPNCBG49_09150
CGHCGC50_12840
CSPUCGC55_01155
FBEFF125_21305
CTSCtha_2188
MROMROS_1219
MMHMmah_0524
MHAZBHR79_00800
MEVMetev_0393 Metev_0932
MPDMCP_2436
MEZMtc_2203
RCIRCIX2438
AGWQT03_C0001G0105
 » show all
Reference
1  [PMID:10896953]
  Authors
Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T
  Title
Extreme halophiles synthesize betaine from glycine by methylation.
  Journal
J Biol Chem 275:22196-201 (2000)
DOI:10.1074/jbc.M910111199
  Sequence
Reference
2  [PMID:11319079]
  Authors
Nyyssola A, Reinikainen T, Leisola M
  Title
Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase.
  Journal
Appl Environ Microbiol 67:2044-50 (2001)
DOI:10.1128/AEM.67.5.2044-2050.2001
  Sequence
Reference
3  [PMID:12466265]
  Authors
Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T
  Title
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.
  Journal
J Biol Chem 278:4932-42 (2003)
DOI:10.1074/jbc.M210970200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.156
IUBMB Enzyme Nomenclature: 2.1.1.156
ExPASy - ENZYME nomenclature database: 2.1.1.156
BRENDA, the Enzyme Database: 2.1.1.156
CAS: 294210-82-5

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