KEGG   ENZYME: 2.1.1.161Help
Entry
EC 2.1.1.161                Enzyme                                 

Name
dimethylglycine N-methyltransferase;
BsmB;
DMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN:R07244]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N,N-dimethylglycine [CPD:C01026]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
betaine [CPD:C00719]
Comment
This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor.
History
EC 2.1.1.161 created 2007
Pathway
ec00260  Glycine, serine and threonine metabolism
Orthology
K13042  dimethylglycine N-methyltransferase
Genes
SYW: SYNW1913(sdmt)
SYX: SynWH7803_0360
SYNR: KR49_11735
PMT: PMT_0551
PMF: P9303_17021
Taxonomy
Reference
1  [PMID:17019606]
  Authors
Lu WD, Chi ZM, Su CD.
  Title
Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis.
  Journal
Arch Microbiol 186:495-506 (2006)
DOI:10.1007/s00203-006-0167-8
  Sequence
[syw:SYNW1913]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.161
IUBMB Enzyme Nomenclature: 2.1.1.161
ExPASy - ENZYME nomenclature database: 2.1.1.161
BRENDA, the Enzyme Database: 2.1.1.161

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