KEGG   ENZYME: 2.1.1.181Help
Entry
EC 2.1.1.181                Enzyme                                 

Name
23S rRNA (adenine1618-N6)-methyltransferase;
rRNA large subunit methyltransferase F;
YbiN protein;
rlmF (gene name);
m6A1618 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (adenine1618-N6)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine1618 in 23S rRNA = S-adenosyl-L-homocysteine + N6-methyladenine1618 in 23S rRNA [RN:R07232]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine1618 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-methyladenine1618 in 23S rRNA
Comment
The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit, but neither the completely assembled 50 S subunits nor completely deproteinized 23 S rRNA [1].
History
EC 2.1.1.181 created 1976 as EC 2.1.1.48, part transferred 2010 to EC 2.1.1.181
Orthology
K06970  23S rRNA (adenine1618-N6)-methyltransferase
Genes
ATH: AT2G21070(FIO1)
ALY: ARALYDRAFT_480956
CRB: 17888846 17892947
CSAT: 104702653 104713551 104751764
EUS: EUTSA_v10000146mg
BNA: 106420602 106420607
BOE: 106337314
THJ: 104807791
CPAP: 110816590
CIT: 102612205
TCC: 18607582
GRA: 105762922
DZI: 111308762
EGR: 104453416
GMX: 100802073
VAR: 108319107
CCAJ: 109812802
LJA: Lj4g3v0217740.1(Lj4g3v0217740.1)
ADU: 107481620
LANG: 109359826
FVE: 101304449
PPER: 18767317
PMUM: 103334800
PAVI: 110753721
MDM: 103409315
CSV: 101205279
CMO: 103490299
CMAX: 111468473
CMOS: 111455141
CPEP: 111811582
RCU: 8265345
JCU: 105650305
HBR: 110673417
POP: 7470383
JRE: 109006580
VVI: 100247029
SLY: 101254840
SPEN: 107008552
CANN: 107839524
NTO: 104111976
SIND: 105169769
OEU: 111380735
HAN: 110921632
LSV: 111898983
DCR: 108196683
BVG: 104903954
SOE: 110786532
NNU: 104593486
OSA: 4328120
DOSA: Os02t0121200-01(Os02g0121200)
BDI: 100835129
ATS: 109766444(LOC109766444)
SBI: 8068259
SITA: 101782727
PDA: 103706342
EGU: 105055058
DCT: 110095485
AOF: 109819811
MNG: MNEG_7697
APRO: F751_5074
ERC: Ecym_6027
NCR: NCU11362
NTE: NEUTE1DRAFT144835(NEUTE1DRAFT_144835)
MGR: MGG_09820
MAW: MAC_04269
MAJ: MAA_02785
CMT: CCM_03996
MBE: MBM_00697
ANI: AN6713.2
ANG: ANI_1_1582064(An07g02250)
ABE: ARB_00675
TVE: TRV_05018
PTE: PTT_11931
MGL: MGL_0651
ECO: b0807(rlmF)
ECJ: JW5107(ybiN)
ECD: ECDH10B_0875(ybiN)
EBW: BWG_0660(rlmF)
ECOK: ECMDS42_0657(ybiN)
ECE: Z1028(ybiN)
ECS: ECs0885
ETW: ECSP_0904(ybiN)
EOJ: ECO26_0934(ybiN)
EOI: ECO111_0868(ybiN)
EOH: ECO103_0843(ybiN)
ECOO: ECRM13514_0884(ybiN)
ECOH: ECRM13516_0839(ybiN)
ECG: E2348C_0759(ybiN)
EOK: G2583_1035(ybiN)
ESO: O3O_07975
ESM: O3M_17285
ESL: O3K_17315
ELH: ETEC_0874
ECC: c0892(ybiN)
ECP: ECP_0821
ECI: UTI89_C0810(ybiN)
ECV: APECO1_1284(ybiN)
ECY: ECSE_0863
ECR: ECIAI1_0845(ybiN)
ECQ: ECED1_0772(ybiN)
ECK: EC55989_0851(ybiN)
ECT: ECIAI39_0785(ybiN)
EOC: CE10_0828(rlmF)
EUM: ECUMN_0951(ybiN)
ECZ: ECS88_0825(ybiN)
ESE: ECSF_0733
EBR: ECB_00774(ybiN)
EBD: ECBD_2816
EKF: KO11_19745(rlmF)
EAB: ECABU_c08490(ybiN)
EDJ: ECDH1ME8569_0760(ybiN)
ENA: ECNA114_0740(ybiN)
ELW: ECW_m0863(rlmF)
ELL: WFL_04195(rlmF)
ELC: i14_0856(ybiN)
ELD: i02_0856(ybiN)
EBL: ECD_00774(rlmF)
EBE: B21_00791(rlmF)
ELF: LF82_2643(ybiN)
ECOI: ECOPMV1_00810(rlmF)
ECOJ: P423_04005
ECOS: EC958_0920(ybiN)
EFE: EFER_2301(ybiN)
STM: STM0826(ybiN)
SEO: STM14_959(ybiN)
SEY: SL1344_0801(ybiN)
SEJ: STMUK_0830(ybiN)
SEB: STM474_0851(ybiN)
SENI: CY43_04420
SPT: SPA1927(ybiN)
SEK: SSPA1796
SHB: SU5_01496
SENS: Q786_04010
SED: SeD_A0921
SEG: SG0804(ybiN)
SEL: SPUL_2149
SET: SEN0771(ybiN)
SENA: AU38_03995
SENO: AU37_03980
SENV: AU39_03985
SENQ: AU40_04440
SENL: IY59_04055
SEEP: I137_09770
SENB: BN855_7960
SENE: IA1_04190
SBG: SBG_0710
SBZ: A464_789
SFL: SF0758(ybiN)
SFX: S0800(ybiN)
SFV: SFV_0791(ybiN)
SFE: SFxv_0826(rlmF)
SFN: SFy_1030
SFS: SFyv_1074
SFT: NCTC1_00767(rlmF)
SSN: SSON_0787(ybiN)
SBO: SBO_0697(ybiN)
SDY: SDY_0790(ybiN)
ENC: ECL_02924
ECLO: ENC_19280
EEC: EcWSU1_01353(rlmF)
ECLX: LI66_06670
ECLY: LI62_07570
ECLZ: LI64_07175
ESA: ESA_02533
CSK: ES15_2627(rlmF)
CTU: CTU_14080(rlmF)
KPN: KPN_00836(ybiN)
KPU: KP1_1793(ybiN)
KPP: A79E_3405
KPT: VK055_1693(rlmF)
KPE: KPK_3733
KPR: KPR_3751(rlmF)
KPJ: N559_3497
KPX: PMK1_03169(rlmF)
KPNU: LI86_17900
KPNK: BN49_1886(rlmF)
KVA: Kvar_3544
KOX: KOX_15110
KOE: A225_1850
EAE: EAE_14605
EAR: CCG31046
CKO: CKO_02316
CRO: ROD_08081
CAMA: F384_03725
EBT: EBL_c25980(ybiN)
EBF: D782_3017
PSTS: E05_09540
YPE: YPO2519
YPK: y1668
YPH: YPC_1603
YPA: YPA_2011
YPN: YPN_2114
YPM: YP_2331
YPZ: YPZ3_2227
YPD: YPD4_2488
YPX: YPD8_2183
YPW: CH59_56
YPJ: CH55_90
YPV: BZ15_1015
YPL: CH46_2593
YPS: YPTB2553
YPO: BZ17_4085
YPY: YPK_1596
YPB: YPTS_2647
YPQ: DJ40_3990(rlmF)
YPU: BZ21_1849
YPR: BZ20_3656
YPC: BZ23_2133
YPF: BZ19_1915
YEN: YE2849
YEY: Y11_17551
YEW: CH47_2201
YET: CH48_3024
YAL: AT01_3898
YFR: AW19_606
YIN: CH53_3240
YKR: CH54_1056
YRO: CH64_3876
YRU: BD65_3120
SPE: Spro_1470
SRL: SOD_c13670(rlmF)
SPLY: Q5A_007415(rlmF)
SMAF: D781_1403
SMAR: SM39_0915
SERF: L085_21180
RAA: Q7S_06515
ECA: ECA0761
PATR: EV46_03325
PATO: GZ59_06680
PCT: PC1_0640
PEC: W5S_0761
SGL: SG0919
SOD: Sant_2685(rlmF)
ETA: ETA_22110
EPY: EpC_23440(rlmF)
EPR: EPYR_02534(ybiN)
EAM: EAMY_1267(ybiN)
EAY: EAM_1265
EBI: EbC_14270
ERJ: EJP617_23800(rlmF)
EGE: EM595_1204(rlmF)
PAM: PANA_1279(ybiN)
PLF: PANA5342_3007(ybiN)
PAJ: PAJ_0599(ybiN)
PVA: Pvag_0657(ybiN)
PSTW: DSJ_09140
TPTY: NCTC11468_01289(rlmF)
PHEI: NCTC12003_00959(rlmF)
ETR: ETAE_2310(ybiN)
ETD: ETAF_2083
ETE: ETEE_0330
PSHI: SAMEA2665130_1488(rlmF)
SACZ: AOT14_03690(rlmF)
VCH: VC1614
VCS: MS6_1396
VCI: O3Y_07835
VVU: VV1_2774
VVY: VV1488
VPA: VP1324
VPB: VPBB_1248
VAG: N646_0357
VSP: VS_1679
VNI: VIBNI_A1571(rlmF)
VAN: VAA_03070
VSC: VSVS12_01622(rlmF)
VTA: A0527(rlmF)
VFI: VF_A1153(ybiN)
AWD: AWOD_II_1294(rlmF)
PPR: PBPRB0892(YPO2519)
PAE: PA3840
PAEV: N297_3966
PAEI: N296_3966
PAU: PA14_14340(ybiN)
PNC: NCGM2_5028(ybiN)
PAEB: NCGM1900_1135(ybiN)
PAEP: PA1S_05620
PAEM: U769_05660
PAEL: T223_05570
PAEG: AI22_27995
PAEC: M802_3964
PAEO: M801_3832
PMY: Pmen_3535
PMK: MDS_3801
PRE: PCA10_11110(rlmF)
PPSE: BN5_3292(rlmF)
PCQ: PcP3B5_50250(rlmF)
PPU: PP_0976(rlmF)
PPF: Pput_1014
PPT: PPS_1004
PPI: YSA_07036
PPX: T1E_1953
PPUH: B479_05175
PPUT: L483_04750
PPUN: PP4_43330(rlmF)
PPUD: DW66_0966
PMON: X969_03250
PMOT: X970_03225
PSB: Psyr_1085
PSYR: N018_20220
PFL: PFL_1062
PPRC: PFLCHA0_c10810(rlmF)
PPRO: PPC_1099
PFS: PFLU_1051
PFB: VO64_4175
PMAN: OU5_2411(rlmF)
PEN: PSEEN4447
PSA: PST_3066
PSTT: CH92_15560
PPUU: PputUW4_04439(rlmF)
PKC: PKB_1012(rlmF)
PSES: PSCI_0701
PSEM: TO66_05350
PSEC: CCOS191_0989(rlmF)
PSOS: POS17_1059
PANR: A7J50_1058
PSET: THL1_1163
PSIL: PMA3_04325
ACX: Achr_30770(rlmF)
PAR: Psyc_0008
PALI: A3K91_0005
PSYA: AOT82_1817
ASJ: AsACE_CH00643(rlmF)
SON: SO_0134(rlmF)
SDN: Sden_0097
SFR: Sfri_0050
SAZ: Sama_3621
SBL: Sbal_4227
SLO: Shew_3741
SSE: Ssed_4429
SPL: Spea_4146
SHL: Shal_0097
SWD: Swoo_4824
SWP: swp_5039
SVO: SVI_4257
SPSW: Sps_05531
CPS: CPS_2268
PHA: PSHAb0296
PAT: Patl_1583
PSM: PSM_B0367
PSEO: OM33_18235
PTN: PTRA_b0439(rlmF)
PEA: PESP_b0540(rlmF)
PSPO: PSPO_b0970(rlmF)
PART: PARC_b0454(rlmF)
PTU: PTUN_b0189(rlmF)
PNG: PNIG_b0418(rlmF)
PTD: PTET_b0463(rlmF)
PSEN: PNC201_17925(rlmF)
MBS: MRBBS_3750(rlmF)
AMAL: I607_13575
AMAE: I876_13960
AMAO: I634_13805
AMAD: I636_13955
AMAI: I635_14330
AMAG: I533_13570
AMAC: MASE_13440
AAUS: EP12_14130
ASP: AOR13_665
GNI: GNIT_0591(rlmF)
GPS: C427_2208
PIN: Ping_0599
MVS: MVIS_3557(rlmF)
MYA: MORIYA_3869(rlmF)
SDE: Sde_0304
HAM: HALO2182
TOL: TOL_1234
OME: OLMES_2336(rlmF)
AHA: AHA_1315
ASA: ASA_1298
AVR: B565_1304
AMED: B224_3869
ASR: WL1483_3104(rlmF)
ACAV: VI35_14895
PSE: NH8B_1039
PLG: NCTC10937_04253(rlmF)
AFQ: AFA_07495
MFA: Mfla_0165
MMB: Mmol_1926
MEH: M301_1018
MBAC: BN1209_0571(rlmF)
GCA: Galf_2157
DSU: Dsui_3226
DAR: Daro_2875
ARC: ABLL_1458
DPS: DP1289
OTM: OSB_04530(rlmF)
PUV: PUV_13010(rlmF)
BTH: BT_4691
BTHO: Btheta7330_03296(rlmF)
BFR: BF3081
BXY: BXY_40070
BOA: Bovatus_04928(rlmF)
DORI: FH5T_12520
MBAS: ALGA_4406
PHE: Phep_0461
SMIZ: 4412673_02898(rlmF)
MUC: MuYL_0071
CHU: CHU_0670
HSW: Hsw_1794
FLM: MY04_4756
GFO: GFO_2659
FJO: Fjoh_2174
FJG: BB050_00470(rlmF)
FPS: FP1768(rlmF)
FBR: FBFL15_1240(rlmF)
FIN: KQS_04460(rlmF)
MARM: YQ22_08190
CBAL: M667_16895
CBAT: M666_16915
DDO: I597_2121(rlmF)
NDO: DDD_2121
MPW: MPR_1284
CHZ: CHSO_1719(rlmF)
WIN: WPG_2481
TJE: TJEJU_2123(rlmF)
TMAR: MARIT_2098(rlmF)
AALG: AREALGSMS7_03727(rlmF)
OAQ: DZC78_04825(rlmF)
KOS: KORDIASMS9_02325(rlmF)
FBA: FIC_01717
 » show all
Taxonomy
Reference
1  [PMID:18021804]
  Authors
Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA
  Title
The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel.
  Journal
J Mol Biol 375:291-300 (2008)
DOI:10.1016/j.jmb.2007.10.051
  Sequence
[eco:b0807]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.181
IUBMB Enzyme Nomenclature: 2.1.1.181
ExPASy - ENZYME nomenclature database: 2.1.1.181
BRENDA, the Enzyme Database: 2.1.1.181

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