KEGG   ENZYME: 2.1.1.183Help
Entry
EC 2.1.1.183                Enzyme                                 

Name
18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase;
18S rRNA dimethylase Dim1p;
Dim1p;
ScDim1;
m2(6)A dimethylase;
KIDIM1
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
Reaction(IUBMB)
4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
Reaction(KEGG)
(other) R10716
Show
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine1779/adenine1780 in 18S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA
Comment
DIM1 is involved in pre-rRNA processing [1].
History
EC 2.1.1.183 created 1976 as EC 2.1.1.48, part transferred 2010 to EC 2.1.1.183
Orthology
K14191  18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
Genes
HSA: 27292(DIMT1)
PTR: 461851(DIMT1)
PPS: 100978649(DIMT1)
GGO: 101150091(DIMT1)
PON: 100434381(DIMT1)
NLE: 100594370(DIMT1)
MCC: 696688(DIMT1)
MCF: 102115642(DIMT1)
CSAB: 103222139(DIMT1)
RRO: 104679565(DIMT1)
RBB: 108514420(DIMT1)
CJC: 100402552(DIMT1)
SBQ: 101044159(DIMT1)
MMU: 66254(Dimt1)
RNO: 294718(Dimt1)
CGE: 100756397(Dimt1)
NGI: 103752499(Dimt1)
HGL: 101721788(Dimt1)
CCAN: 109696673(Dimt1)
OCU: 100353533(DIMT1)
TUP: 102485863(DIMT1)
CFA: 100688153(DIMT1) 478072
AML: 100471088(DIMT1)
UMR: 103663646(DIMT1)
ORO: 101385174(DIMT1)
FCA: 101100359(DIMT1)
PTG: 102961193(DIMT1)
AJU: 106976389(DIMT1)
BTA: 509725(DIMT1)
BOM: 102286876(DIMT1)
BIU: 109574851(DIMT1)
PHD: 102321743(DIMT1)
CHX: 100861255(DIMT1)
OAS: 101107044(DIMT1)
SSC: 100625553(DIMT1)
CFR: 102506495(DIMT1)
CDK: 105084735(DIMT1)
BACU: 102998421(DIMT1)
LVE: 103071668 103074118(DIMT1)
OOR: 101274930(DIMT1)
ECB: 100059778(DIMT1)
EPZ: 103564713(DIMT1)
EAI: 106846771(DIMT1)
MYB: 102242604(DIMT1)
MYD: 102757049(DIMT1)
HAI: 109392875(DIMT1)
RSS: 109453713(DIMT1)
PALE: 102880471(DIMT1)
LAV: 100673172(DIMT1)
TMU: 101355342
MDO: 100018334(DIMT1)
SHR: 100919828(DIMT1) 100932837
OAA: 100087017(DIMT1)
GGA: 427157(DIMT1)
MGP: 100538863(DIMT1)
CJO: 107306030(DIMT1)
APLA: 101796862(DIMT1)
ACYG: 106035606(DIMT1)
GFR: 102034725(DIMT1)
FAB: 101812331(DIMT1)
PHI: 102108178(DIMT1)
PMAJ: 107216135(DIMT1)
CCW: 104686774(DIMT1)
FPG: 101922202(DIMT1)
FCH: 102047770(DIMT1)
CLV: 102098281(DIMT1)
EGZ: 104132516(DIMT1)
AAM: 106483777(DIMT1) 106484237
ASN: 102387257(DIMT1)
AMJ: 102560916(DIMT1)
PSS: 102457067(DIMT1)
CMY: 102945245(DIMT1)
CPIC: 101940660(DIMT1)
ACS: 100553894(dimt1)
PVT: 110073937(DIMT1)
PBI: 103052666(DIMT1)
GJA: 107114791(DIMT1)
XLA: 734747(dimt1.L)
XTR: 779588(dimt1)
NPR: 108799179(DIMT1)
DRE: 445162(dimt1l)
SRX: 107710917(dimt1) 107736556
SGH: 107548358(dimt1) 107599822
CCAR: 109112314(dimt1)
IPU: 108265368(dimt1)
AMEX: 103025079(dimt1)
TRU: 101072586(dimt1)
LCO: 104925890(dimt1)
NCC: 104943775(dimt1)
MZE: 101485688(dimt1)
OLA: 101156415(dimt1)
XMA: 102231589(dimt1)
PRET: 103470414(dimt1)
NFU: 107393906(dimt1)
CSEM: 103398286(dimt1)
LCF: 108878538(dimt1)
HCQ: 109514201(dimt1)
BPEC: 110156740(dimt1)
SASA: 100196530(dimt1)
ELS: 105014284(dimt1)
SFM: 108938649(dimt1)
LCM: 102358570(DIMT1)
CMK: 103177799(dimt1)
CIN: 104266212
SPU: 574553
APLC: 110977795
SKO: 100377835
DME: Dmel_CG11837(CG11837)
DSI: Dsimw501_GD21406(Dsim_GD21406)
MDE: 101901091
AAG: 5563560
AME: 552043
BIM: 100743201
BTER: 100647079
ACEP: 105621926
PBAR: 105422460
HST: 105192424
CFO: 105255549
LHU: 105675304
PGC: 109853143
NVI: 100116212
TCA: 661358
DPA: 109534736
NVL: 108568201
PMAC: 106709263
PRAP: 111003847
PXY: 105391711
API: 100164336
DNX: 107162185
ZNE: 110827768
FCD: 110847868
CEL: CELE_E02H1.1(E02H1.1)
CBR: CBG00961
BMY: Bm1_54155
TSP: Tsp_00414
CRG: 105331288
MYI: 110445954
OBI: 106876003
LAK: 106166455
SHX: MS3_00980
EGL: EGR_07308
EPA: 110255126
ADF: 107347582
HMG: 100204197
AQU: 100636833
ATH: AT2G47420(DIM1A) AT5G66360(DIM1B)
LJA: Lj3g3v0807650.1(Lj3g3v0807650.1)
DOSA: Os06t0490000-01(Os06g0490000) Os07t0509600-01(Os07g0509600) Os10t0183900-01(Os10g0183900)
ATS: 109733413(LOC109733413) 109736072(LOC109736072) 109738046(LOC109738046)
ZMA: 100192593 100284053(pco116085)
MNG: MNEG_9198
APRO: F751_5813
SCE: YPL266W(DIM1)
ERC: Ecym_3003
KMX: KLMA_80016(DIM1)
NCS: NCAS_0D02250(NCAS0D02250)
NDI: NDAI_0I02710(NDAI0I02710)
TPF: TPHA_0J00200(TPHA0J00200)
TBL: TBLA_0A07080(TBLA0A07080)
TDL: TDEL_0G04700(TDEL0G04700)
KAF: KAFR_0B06450(KAFR0B06450)
PIC: PICST_75487(DIM1)
CAL: CAALFM_C113730CA(DIM1)
CAUR: QG37_06157
SLB: AWJ20_2799(DIM1)
NCR: NCU08968
NTE: NEUTE1DRAFT56261(NEUTE1DRAFT_56261)
MGR: MGG_17491
SSCK: SPSK_04029
MAW: MAC_02583
MAJ: MAA_03056
CMT: CCM_00325
BFU: BCIN_09g02170(Bcdim1)
MBE: MBM_07897
ANI: AN3313.2
ANG: ANI_1_2026024(An02g14660)
ABE: ARB_05072
TVE: TRV_06678
PTE: PTT_04321
CNE: CNJ00110
CNB: CNBJ3380
ABP: AGABI1DRAFT46548(AGABI1DRAFT_46548)
ABV: AGABI2DRAFT210241(AGABI2DRAFT_210241)
MGL: MGL_3848
DDI: DDB_G0283789(dimt1l)
DFA: DFA_10959(dimt1l)
EHI: EHI_013870(424.t00003)
PYO: PY17X_1029300(PY06971)
PCB: PCHAS_102770(PC001400.02.0)
TAN: TA08645
TPV: TP04_0475
BBO: BBOV_II001100(18.m06080)
CPV: cgd6_930
SMIN: v1.2.005464.t1(symbB.v1.2.005464.t1) v1.2.017900.t1(symbB.v1.2.017900.t1)
 » show all
Taxonomy
Reference
1  [PMID:7590228]
  Authors
Lafontaine D, Vandenhaute J, Tollervey D
  Title
The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.
  Journal
Genes Dev 9:2470-81 (1995)
DOI:10.1101/gad.9.20.2470
Reference
2  [PMID:9528805]
  Authors
Lafontaine DL, Preiss T, Tollervey D
  Title
Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?
  Journal
Mol Cell Biol 18:2360-70 (1998)
DOI:10.1128/MCB.18.4.2360
Reference
3  [PMID:19520088]
  Authors
Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP
  Title
Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases.
  Journal
J Mol Biol 391:884-93 (2009)
DOI:10.1016/j.jmb.2009.06.015
Reference
4  [PMID:8064863]
  Authors
Lafontaine D, Delcour J, Glasser AL, Desgres J, Vandenhaute J
  Title
The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast.
  Journal
J Mol Biol 241:492-7 (1994)
DOI:10.1006/jmbi.1994.1525
  Sequence
[sce:YPL266W]
Reference
5  [PMID:16540698]
  Authors
O'Farrell HC, Pulicherla N, Desai PM, Rife JP
  Title
Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution.
  Journal
RNA 12:725-33 (2006)
DOI:10.1261/rna.2310406
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.183
IUBMB Enzyme Nomenclature: 2.1.1.183
ExPASy - ENZYME nomenclature database: 2.1.1.183
BRENDA, the Enzyme Database: 2.1.1.183

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