KEGG   ENZYME: 2.1.1.2Help
Entry
EC 2.1.1.2                  Enzyme                                 

Name
guanidinoacetate N-methyltransferase;
GA methylpherase;
guanidinoacetate methyltransferase;
guanidinoacetate transmethylase;
methionine-guanidinoacetic transmethylase;
guanidoacetate methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine [RN:R01883]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanidinoacetate [CPD:C00581]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
creatine [CPD:C00300]
History
EC 2.1.1.2 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00542  guanidinoacetate N-methyltransferase
Genes
HSA: 2593(GAMT)
PTR: 749982(GAMT)
PPS: 100973784(GAMT)
GGO: 101150449(GAMT)
PON: 100434735(GAMT)
NLE: 100604929(GAMT)
MCC: 721263(GAMT)
MCF: 102120326(GAMT)
CSAB: 103233606(GAMT)
RRO: 104671415(GAMT)
RBB: 108530253(GAMT)
CJC: 100394705(GAMT)
SBQ: 101034312(GAMT)
MMU: 14431(Gamt)
RNO: 25257(Gamt)
CGE: 100755964(Gamt)
NGI: 103737328(Gamt)
HGL: 101701700(Gamt)
CCAN: 109691010(Gamt)
TUP: 102486225(GAMT)
CFA: 485085(GAMT)
AML: 100478678(GAMT)
UMR: 103681783(GAMT)
ORO: 101373126(GAMT)
FCA: 101096703(GAMT)
PTG: 102972234(GAMT)
AJU: 106983718(GAMT)
BTA: 515270(GAMT)
BOM: 102277266(GAMT)
BIU: 109561988(GAMT)
PHD: 102317697(GAMT)
CHX: 102176603(GAMT)
OAS: 101114955(GAMT)
SSC: 100625146(GAMT)
CFR: 102522185(GAMT)
CDK: 105104108(GAMT)
BACU: 102999076(GAMT)
LVE: 103069008(GAMT)
OOR: 101289055(GAMT)
ECB: 100068840(GAMT)
EPZ: 103544271(GAMT)
EAI: 106834186(GAMT)
MYB: 102240125(GAMT)
MYD: 102765033(GAMT)
HAI: 109390668(GAMT)
RSS: 109453994(GAMT)
PALE: 102878441(GAMT)
TMU: 101353747
MDO: 100015231(GAMT)
SHR: 100926458(GAMT)
OAA: 103164686(GAMT)
GGA: 770737(GAMT)
MGP: 100544992(GAMT)
CJO: 107325467(GAMT)
APLA: 101803779(GAMT)
ACYG: 106048218(GAMT)
TGU: 100218458(GAMT)
GFR: 102031970(GAMT)
FAB: 101818937(GAMT)
PHI: 102112087(GAMT)
PMAJ: 107215490(GAMT)
CCAE: 111940328(GAMT)
CCW: 104697066(GAMT)
FPG: 101922263(GAMT)
FCH: 102052811(GAMT)
CLV: 102093632(GAMT)
EGZ: 104128293(GAMT)
AAM: 106486552(GAMT)
ASN: 102376844(GAMT)
AMJ: 102571343(GAMT)
PSS: 102458769(GAMT)
CMY: 102941606(GAMT)
CPIC: 101931504(GAMT)
ACS: 100566527(gamt)
PVT: 110072519(GAMT)
PBI: 103066981 103068008(GAMT)
GJA: 107115757(GAMT)
XLA: 380384(gamt.S) 733150(gamt.L)
XTR: 394491(gamt)
NPR: 108792400(GAMT)
DRE: 796865(gamt)
IPU: 100528342(gamt)
AMEX: 103023041(gamt)
TRU: 101067635(gamt)
LCO: 104928396(gamt)
NCC: 104946919(gamt)
MZE: 101466486(gamt)
OLA: 101166292(gamt)
XMA: 102217090(gamt)
PRET: 103463348(gamt)
NFU: 107392816(gamt)
KMR: 108234267(gamt)
CSEM: 103395941(gamt)
LCF: 108877437(gamt)
SDU: 111216321(gamt)
HCQ: 109519128(gamt)
BPEC: 110167651(gamt)
MALB: 109966838(gamt)
SASA: 100196494(gamt) 106573878
ELS: 105029301(gamt)
SFM: 108930551(gamt)
LCM: 102360926(GAMT)
CMK: 103181936(gamt)
CIN: 100176150 100181581 664631(gamt1) 664632(gamt2) 664633(gamt3)
SPU: 578397
APLC: 110978082
SKO: 100376150
LAK: 106178783
EPA: 110239991
ADF: 107336691
AQU: 100636366
SPAR: SPRG_14186
AOI: AORI_2931
WIN: WPG_0392
 » show all
Taxonomy
Reference
1
  Authors
Cantoni, G.L. and Scarano, E.
  Title
The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions.
  Journal
J Am Chem Soc 76:4744 (1954)
Reference
2  [PMID:13192118]
  Authors
CANTONI GL, VIGNOS PJ Jr.
  Title
Enzymatic mechanism of creatine synthesis.
  Journal
J Biol Chem 209:647-59 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.2
IUBMB Enzyme Nomenclature: 2.1.1.2
ExPASy - ENZYME nomenclature database: 2.1.1.2
BRENDA, the Enzyme Database: 2.1.1.2
CAS: 9029-75-8

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