KEGG   ENZYME: 2.1.1.206Help
Entry
EC 2.1.1.206                Enzyme                                 

Name
tRNA (cytidine56-2'-O)-methyltransferase;
aTrm56;
tRNA ribose 2'-O-methyltransferase aTrm56;
PAB1040 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytidine56 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylcytidine56 in tRNA
Comment
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
History
EC 2.1.1.206 created 2011
Orthology
K07254  tRNA (cytidine56-2'-O)-methyltransferase
Genes
MJA: MJ_1385
MFE: Mefer_0592
MVU: Metvu_0176
MFS: MFS40622_0541
MIF: Metin_0231
MJH: JH146_0372
MIG: Metig_1799
MMP: MMP1425
MMQ: MmarC5_0153
MMX: MmarC6_1248
MMD: GYY_07960
MAE: Maeo_1410
MVO: Mvol_1037
MTH: MTH_1113
METC: MTCT_1007
METE: tca_01069
MST: Msp_1167
MSI: Msm_0932
MRU: mru_1893
MEB: Abm4_0323
MMIL: sm9_1882
MEYE: TL18_08850
MOL: YLM1_1348
METH: MBMB1_1643
MFC: BRM9_0897
MCUB: MCBB_1950
MFV: Mfer_0122
MKA: MK0803
AFU: AF_0751
FPL: Ferp_1796
GAC: GACE_0721
GAH: GAH_02047
TAC: Ta0931
TVO: TVG1129508(TVG1129508)
PTO: PTO0696
FAI: FAD_1482
CDIV: CPM_1236
ABI: Aboo_0493
PHO: PH0461(PH0461)
PAB: PAB1040
PFU: PF0461
PFI: PFC_01420
PYN: PNA2_1092
PYS: Py04_0643
TKO: TK0060
TON: TON_1167
TGA: TGAM_1164
TSI: TSIB_1085
THE: GQS_09740
THA: TAM4_2086
THM: CL1_1536
TLT: OCC_07621
THS: TES1_1266
TNU: BD01_1130
TEU: TEU_11540
PPAC: PAP_07235
MAC: MA_3241
MBAR: MSBR2_0124
MBAK: MSBR3_0181
MMA: MM_0086
MMAC: MSMAC_2592
METM: MSMTP_1231
MTHE: MSTHC_0573
MTHR: MSTHT_0155
MHOR: MSHOH_2090
MBU: Mbur_0256
MMET: MCMEM_0873
MMH: Mmah_1277
MPY: Mpsy_0110
MTP: Mthe_1667
MCJ: MCON_3465
MHI: Mhar_0634
MHU: Mhun_2799
MLA: Mlab_0456
MEMA: MMAB1_2390
MPI: Mpet_1609
MBN: Mboo_1277
MPL: Mpal_2011
MPD: MCP_1507
MEZ: Mtc_1741
RCI: LRC271
HAL: VNG_0755C
HSL: OE_2117F(trm56)
HHB: Hhub_1875(trm56)
HALH: HTSR_1132
HHSR: HSR6_1167
HMA: rrnAC0857
HHI: HAH_1495
NPH: NP_4110A(trm56)
NMO: Nmlp_1943(trm56)
HUT: Huta_0284
HTI: HTIA_0466
HMU: Hmuk_2326
HWA: HQ_2492A(trm56)
HWC: Hqrw_2788(trm56)
HVO: HVO_1173(trm56)
HME: HFX_1186
HLA: Hlac_1701
HTU: Htur_0969
NMG: Nmag_3160(trm56)
NAT: NJ7G_3541
SALI: L593_09495
ACJ: ACAM_1260
SMR: Smar_0917
IHO: Igni_1123
IIS: EYM_02835
DKA: DKAM_1271
TAG: Tagg_1277
IAG: Igag_0104
HBU: Hbut_1137
STO: STK_03330
SSO: SSO0267
SOL: Ssol_1245
SSOA: SULA_1286
SSOL: SULB_1287
SSOF: SULC_1285
SAI: Saci_0653
SID: M164_1880
SII: LD85_2092
SIH: SiH_1809
SIR: SiRe_1729
SIC: SiL_1723
MSE: Msed_2278
MCN: Mcup_2024
TPE: Tpen_0709
ASC: ASAC_0292
ACIA: SE86_02260
NMR: Nmar_1606
NCT: NMSP_1548
NEV: NTE_00448
NCV: NCAV_0128
NBV: T478_1324
NDV: NDEV_1964
MARH: Mia14_0749
BARC: AOA65_2251
BARB: AOA66_0957
 » show all
Taxonomy
Reference
1  [PMID:15987815]
  Authors
Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A
  Title
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP.
  Journal
RNA 11:1051-63 (2005)
DOI:10.1261/rna.2110805
  Sequence
[pab:PAB1040]
Reference
2  [PMID:18068186]
  Authors
Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S
  Title
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA.
  Journal
J Mol Biol 375:1064-75 (2008)
DOI:10.1016/j.jmb.2007.11.023
  Sequence
[pho:PH0461]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.206
IUBMB Enzyme Nomenclature: 2.1.1.206
ExPASy - ENZYME nomenclature database: 2.1.1.206
BRENDA, the Enzyme Database: 2.1.1.206

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