KEGG   ENZYME: 2.1.1.208Help
Entry
EC 2.1.1.208                Enzyme                                 

Name
23S rRNA (uridine2479-2'-O)-methyltransferase;
AviRb
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + uridine2479 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
uridine2479 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methyluridine2479 in 23S rRNA
Comment
Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.
History
EC 2.1.1.208 created 2011
Orthology
K21514  23S rRNA (uridine2479-2'-O)-methyltransferase
Genes
RUK: A4V00_07330
NFA: NFA_38300
NFR: ERS450000_00068(rlmB)
NCY: NOCYR_3709
NBR: O3I_029940
NSL: BOX37_20765
NSR: NS506_06087
RHA: RHA1_ro06776
ROP: ROP_67620
ROA: Pd630_LPD03396
RHU: A3Q40_01470(aviRb_1)
SCT: SCAT_4150(aviRb)
SALB: XNR_4256
SAMB: SAM23877_4265(aviRb)
BCV: Bcav_2329
LMOI: VV02_24605
XCE: Xcel_0332
SERJ: SGUI_0689
KFL: Kfla_6197
SRO: Sros_9079
KAL: KALB_4297
ACTI: UA75_07235
ACAD: UA74_07240
AHG: AHOG_06960(aviRb1)
MIL: ML5_0438
ASE: ACPL_1030
ACTN: L083_1714
AFS: AFR_08460
ACTS: ACWT_0912
CAI: Caci_0573
LBF: LBF_1992
 » show all
Taxonomy
Reference
1  [PMID:15581897]
  Authors
Mosbacher TG, Bechthold A, Schulz GE
  Title
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
  Journal
J Mol Biol 345:535-45 (2005)
DOI:10.1016/j.jmb.2004.10.051
  Sequence
Reference
2  [PMID:12828631]
  Authors
Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S
  Title
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the  guanosine 2535 base and the uridine 2479 ribose.
  Journal
Mol Microbiol 49:309-18 (2003)
DOI:10.1046/j.1365-2958.2003.03558.x
  Sequence
Reference
3  [PMID:11181344]
  Authors
Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A
  Title
An ATP-binding cassette transporter and two rRNA methyltransferases are involved  in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
  Journal
Antimicrob Agents Chemother 45:690-5 (2001)
DOI:10.1128/AAC.45.3.690-695.2001
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.208
IUBMB Enzyme Nomenclature: 2.1.1.208
ExPASy - ENZYME nomenclature database: 2.1.1.208
BRENDA, the Enzyme Database: 2.1.1.208

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