KEGG   ENZYME: 2.1.1.214Help
Entry
EC 2.1.1.214                Enzyme                                 

Name
tRNA (guanine10-N2)-methyltransferase;
(m2G10) methyltransferase;
Trm11-Trm112 complex
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine10 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine10 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N2-methylguanine10 in tRNA
Comment
In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.
History
EC 2.1.1.214 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.214)
Orthology
K15430  tRNA (guanine10-N2)-methyltransferase
Genes
HSA: 60487(TRMT11)
PTR: 745151(TRMT11)
PPS: 100987629(TRMT11)
GGO: 101128114(TRMT11)
PON: 100174524(TRMT11)
NLE: 100589318(TRMT11)
MCC: 712712(TRMT11)
MCF: 102125600(TRMT11)
CSAB: 103223623 103240419(TRMT11)
RRO: 104659966(TRMT11)
RBB: 108522660(TRMT11)
CJC: 100397738(TRMT11)
SBQ: 101052491(TRMT11)
MMU: 73681(Trmt11)
RNO: 378794(Trmt11)
CGE: 100774416(Trmt11)
NGI: 103744721(Trmt11)
HGL: 101719219(Trmt11)
CCAN: 109698218(Trmt11)
OCU: 100338244(TRMT11)
CFA: 476285(TRMT11)
AML: 100468309(TRMT11)
UMR: 103663433(TRMT11)
ORO: 101377120(TRMT11)
FCA: 101084627(TRMT11)
PTG: 102961283(TRMT11)
AJU: 106986151(TRMT11)
BTA: 514867(TRMT11)
BOM: 102281678(TRMT11)
BIU: 109563751(TRMT11)
PHD: 102341009(TRMT11)
CHX: 102180226(TRMT11)
OAS: 101117511(TRMT11)
SSC: 100152782(TRMT11)
CFR: 102509536(TRMT11)
CDK: 105096321(TRMT11)
BACU: 103016383(TRMT11)
LVE: 103079726(TRMT11)
OOR: 101272406(TRMT11)
ECB: 100073022(TRMT11)
EPZ: 103567978(TRMT11)
EAI: 106841997(TRMT11)
MYB: 102249378(TRMT11)
MYD: 102767755(TRMT11)
HAI: 109392618(TRMT11)
RSS: 109446258(TRMT11)
PALE: 102886136(TRMT11)
LAV: 100660821
TMU: 101341850
MDO: 100030752(TRMT11)
SHR: 100921700(TRMT11)
OAA: 100075188(TRMT11)
GGA: 378793(TRMT11)
MGP: 100547621(TRMT11)
CJO: 107311736(TRMT11)
APLA: 101791890(TRMT11)
ACYG: 106032413(TRMT11)
TGU: 100221498(TRMT11)
GFR: 102043725(TRMT11)
FAB: 101817274(TRMT11)
PHI: 102112911(TRMT11)
PMAJ: 107201886(TRMT11)
CCAE: 111927226(TRMT11)
CCW: 104690857(TRMT11)
FPG: 101919248(TRMT11)
FCH: 102056335(TRMT11)
CLV: 102085580(TRMT11)
EGZ: 104131976(TRMT11)
AAM: 106497882(TRMT11)
ASN: 102368288(TRMT11)
AMJ: 102558942(TRMT11)
PSS: 102452300(TRMT11)
CMY: 102939994(TRMT11)
CPIC: 101938490(TRMT11)
ACS: 100566530(trmt11)
PVT: 110077556(TRMT11)
GJA: 107121015(TRMT11)
XLA: 432012(trmt11.L)
XTR: 100497209(trmt11)
NPR: 108792916(TRMT11)
DRE: 393185(trmt11)
CCAR: 109091941
IPU: 108270150(trmt11)
AMEX: 103030151(trmt11)
TRU: 445946(trmt11)
NCC: 104940766(trmt11)
MZE: 101467248(trmt11)
OLA: 101166247(trmt11)
XMA: 102232529(trmt11)
PRET: 103478329(trmt11)
NFU: 107378791(trmt11)
KMR: 108232187(trmt11)
CSEM: 103388595(trmt11)
LCF: 108888460(trmt11)
SDU: 111227775(trmt11)
HCQ: 109531409(trmt11)
BPEC: 110171751(trmt11)
MALB: 109958359(trmt11)
ELS: 105019201(trmt11)
SFM: 108937175(trmt11)
LCM: 102348337(TRMT11)
CMK: 103182303(trmt11)
CIN: 100177819
SPU: 576775
APLC: 110985079
SKO: 100376402
DME: Dmel_CG1074(CG1074)
DER: 6552154
DPE: 6592090
DSI: Dsimw501_GD19733(Dsim_GD19733)
DWI: 6650109
MDE: 101900492
AAG: 5563705
AME: 724798
BIM: 100745941
BTER: 100645308
SOC: 105201784
AEC: 105151477
PBAR: 105425266
HST: 105187251
DQU: 106741704
CFO: 105252775
LHU: 105671790
PGC: 109857890
PCF: 106787357
NVI: 100115843
MDL: 103575883
TCA: 663262
NVL: 108565882
BMOR: 101739217
PMAC: 106711848
PRAP: 110992088
HAW: 110380030
API: 100164143
DNX: 107173479
CLEC: 106660972
FCD: 110853918
TUT: 107371346
CEL: CELE_Y71F9AL.1(Y71F9AL.1)
CBR: CBG04220
TSP: Tsp_12893
CRG: 105333634
MYI: 110446419
OBI: 106877536
SHX: MS3_04316
EGL: EGR_06834
ADF: 107341719
HMG: 101237027
ATH: AT3G26410(TRM11)
CRB: 17886537
THJ: 104818254
CPAP: 110816213
TCC: 18608470
DZI: 111308397
EGR: 104452761
VRA: 106752841
VAR: 108333327
CCAJ: 109805043
LJA: Lj0g3v0121919.1(Lj0g3v0121919.1) Lj4g3v0336710.1(Lj4g3v0336710.1)
ADU: 107481737
AIP: 107631602
LANG: 109346105
FVE: 101303719
PPER: 109949794
PMUM: 103344676
PAVI: 110759689
MDM: 103450959
PXB: 103962913
ZJU: 107412023
CSV: 101207825
CMO: 103489693
MCHA: 111017553
CMAX: 111472466
CMOS: 111439552
CPEP: 111776476
RCU: 8280808
JCU: 105643961
HBR: 110639918
POP: 7473017
JRE: 109000625
VVI: 100255656
SLY: 101246388
SPEN: 107032017
SOT: 102592975
NSY: 104239456
NTO: 104086530
INI: 109167117
SIND: 105169184
OEU: 111409771
HAN: 110928891
LSV: 111899004
CCAV: 112500886
DCR: 108224411
BVG: 104907696
SOE: 110802590
NNU: 104587932
OSA: 4329664
DOSA: Os02t0556400-01(Os02g0556400)
OBR: 102716378
BDI: 100840754
ATS: 109766832(LOC109766832) 109786617(LOC109786617)
SBI: 8064270
ZMA: 100280406
SITA: 101772864
PDA: 103704842
EGU: 105051734
MUS: 103997451
DCT: 110097749
AOF: 109823947
ATR: 18448326
PPP: 112290849
MNG: MNEG_0930
APRO: F751_6093
SCE: YOL124C(TRM11)
ERC: Ecym_2049
KMX: KLMA_80247(TRM11)
NCS: NCAS_0C04590(NCAS0C04590)
NDI: NDAI_0G03960(NDAI0G03960)
TPF: TPHA_0P01320(TPHA0P01320)
TBL: TBLA_0B08600(TBLA0B08600)
TDL: TDEL_0E00590(TDEL0E00590)
KAF: KAFR_0C01690(KAFR0C01690)
CAL: CAALFM_C305140CA(CaO19.5987)
CAUR: QG37_05248
SLB: AWJ20_2926(TRM11)
NCR: NCU04407
NTE: NEUTE1DRAFT79436(NEUTE1DRAFT_79436)
MGR: MGG_06857
SSCK: SPSK_07328
MAW: MAC_09089
MAJ: MAA_00267
CMT: CCM_00751
MBE: MBM_05933
ANI: AN3647.2
ANG: ANI_1_2722014(An01g07400)
ABE: ARB_00432
TVE: TRV_02688
PTE: PTT_15965
SPO: SPBC16D10.02(trm11)
CNE: CNK00740
CNB: CNBK2760
ABP: AGABI1DRAFT80852(AGABI1DRAFT_80852)
ABV: AGABI2DRAFT203746(AGABI2DRAFT_203746)
MGL: MGL_2029
DDI: DDB_G0283969(trmt11)
DFA: DFA_08055(trmt11)
EHI: EHI_023130(25.t00002)
PYO: PY17X_1361900(PY05490)
PCB: PCHAS_136080(PC000313.00.0)
TAN: TA03045
TPV: TP01_0635
BBO: BBOV_IV002880(21.m02958)
CPV: cgd5_4420
SMIN: v1.2.032062.t1(symbB.v1.2.032062.t1)
 » show all
Taxonomy
Reference
1  [PMID:15899842]
  Authors
Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B
  Title
Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA.
  Journal
Mol Cell Biol 25:4359-70 (2005)
DOI:10.1128/MCB.25.11.4359-4370.2005
  Sequence
[sce:YOL124C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.214
IUBMB Enzyme Nomenclature: 2.1.1.214
ExPASy - ENZYME nomenclature database: 2.1.1.214
BRENDA, the Enzyme Database: 2.1.1.214

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