KEGG   ENZYME: 2.1.1.217Help
Entry
EC 2.1.1.217                Enzyme                                 

Name
tRNA (adenine22-N1)-methyltransferase;
TrmK;
YqfN;
Sp1610 (gene name);
tRNA: m1A22 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (adenine22-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine22 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine22 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine22 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine22 in tRNA
Comment
The enzyme specifically methylates adenine22 in tRNA.
History
EC 2.1.1.217 created 2011 (EC 2.1.1.36 created 1972, part transferred 2011 to EC 2.1.1.217)
Orthology
K06967  tRNA (adenine22-N1)-methyltransferase
Genes
VCH: VCA0634
VCF: IR04_02700
VCS: MS6_A0684
VCE: Vch1786_II0317
VCQ: EN18_01560
VCJ: VCD_000688
VCI: O3Y_16503
VCO: VC0395_0578
VCR: VC395_A0678
VCM: VCM66_A0592
VVU: VV2_0386
VVY: VVA0944
VSP: VS_II0155
VAN: VAA_00630
VSC: VSVS12_03178(trmK)
VTA: B0584
VFI: VF_A0955
PPU: PP_3495(trmK)
PPF: Pput_2276
PPT: PPS_2980
PPI: YSA_11357
PPX: T1E_2028
PPUH: B479_14815
PPUT: L483_18360
PPUN: PP4_23570
PPUD: DW66_3245
PMON: X969_14270
PMOT: X970_13915
PSB: Psyr_4328
PSYR: N018_22440
PFL: PFL_2370
PPRO: PPC_2410
PFS: PFLU_4258
PFB: VO64_5267
PMAN: OU5_1014
PEN: PSEEN2384
PSES: PSCI_0145
PSEM: TO66_21235
PSOS: POS17_2373
PANR: A7J50_3919
PSIL: PMA3_18210
SON: SO_2449(trmK)
SDN: Sden_2403
SLO: Shew_2722
SPL: Spea_2945
SHL: Shal_3035
SWP: swp_3591
SVO: SVI_1308
SPSW: Sps_03916
CPS: CPS_2668
PSM: PSM_A1916
PSEO: OM33_18190
PEA: PESP_a2509(trmK)
PSPO: PSPO_b0978(trmK)
PART: PARC_a1358(trmK)
PTU: PTUN_b0628(trmK)
PTD: PTET_a2195(trmK)
PIN: Ping_1811
SDE: Sde_1557
TOL: TOL_1560
PLG: NCTC10937_01998(trmK)
BBAC: EP01_17700
BMX: BMS_1844
BSU: BSU25180(trmK)
BSR: I33_2600
BSL: A7A1_3231
BSH: BSU6051_25180(trmK)
BSUT: BSUB_02695(trmK)
BSUL: BSUA_02695(trmK)
BSUS: Q433_13770
BSS: BSUW23_12480(trmK)
BST: GYO_2782
BSO: BSNT_08959(yqfN)
BSQ: B657_25180(trmK)
BSX: C663_2400(yqfN)
BLI: BL03696(yqfN)
BLD: BLi02697(trmK)
BLH: BaLi_c27840(trmK)
BAY: RBAM_023490(yqfN)
BAQ: BACAU_2361(yqfN)
BYA: BANAU_2499(yqfN)
BAMP: B938_12130
BAML: BAM5036_2268(trmK)
BAMA: RBAU_2482(trmK)
BAMN: BASU_2271(trmK)
BAMB: BAPNAU_1234(yqfN)
BAMT: AJ82_13275
BAMY: V529_26210
BMP: NG74_02453(trmK)
BAO: BAMF_2416(trmK)
BAZ: BAMTA208_12920(trmK)
BQL: LL3_02713(trmK)
BXH: BAXH7_02638(yqfN)
BQY: MUS_2813
BAMI: KSO_007645
BAMC: U471_24300
BAMF: U722_12755
BHA: BH1379
BAN: BA_4513
BAR: GBAA_4513
BAT: BAS4192
BAI: BAA_4534
BANT: A16_45100
BANR: A16R_45670
BANS: BAPAT_4331
BANV: DJ46_3197
BCE: BC4287
BCA: BCE_4370
BCQ: BCQ_4077
BCX: BCA_4401
BNC: BCN_4202
BCF: bcf_21330
BCER: BCK_13725
BTL: BALH_3883
BTT: HD73_4595
BTHI: BTK_22635
BTM: MC28_3582
BTG: BTB_c44330(trmK)
BTI: BTG_27685
BTW: BF38_47
BWW: bwei_0644(trmK)
BMYO: BG05_1728
BMYC: DJ92_1394
BCL: ABC1692
BPU: BPUM_2251
BPUM: BW16_12185
BPUS: UP12_11420
BMQ: BMQ_4539
BMD: BMD_4525
BMEG: BG04_1530
BAG: Bcoa_2786
BCOA: BF29_775
BJS: MY9_2541
BMET: BMMGA3_11875(trmK)
BACW: QR42_11365
BACP: SB24_16995
BACB: OY17_15000
BACO: OXB_2927
BACY: QF06_10775
BACL: BS34A_27590(trmK)
BALM: BsLM_2475
BEO: BEH_20005
BGY: BGLY_2970
BKW: BkAM31D_05460(trmK)
BBEV: BBEV_1236(trmK)
OIH: OB1941
GKA: GK2479
GTN: GTNG_2416
GGH: GHH_c25540(trmK)
GEA: GARCT_02461(trmK)
AFL: Aflv_0859
AAMY: GFC30_2674
AXL: AXY_11240
LSP: Bsph_3699
HHD: HBHAL_3545(yqfN)
VPN: A21D_03207(trmK)
BSE: Bsel_2342
SAU: SA1389
SAV: SAV1560
SAW: SAHV_1547
SAM: MW1512
SAS: SAS1498
SAR: SAR1637
SAC: SACOL1617
SAE: NWMN_1463
SAD: SAAV_1552
SUE: SAOV_1560
SUZ: MS7_1577(trmK)
SUG: SAPIG1625
SAUA: SAAG_01474
SAUS: SA40_1431
SAUU: SA957_1514
SAUG: SA268_1518
SAUF: X998_1585
SAB: SAB1432c
SAUB: C248_1603
SAUC: CA347_1556
SAUR: SABB_00480
SAUI: AZ30_07955
SAUD: CH52_11265
SAMS: NI36_08410
SEP: SE1247
SER: SERP1126
SEPP: SEB_01267
SEPS: DP17_204
SHA: SH1356
SHH: ShL2_01238(trmK)
SSP: SSP1196
SCA: SCA_1181
SDT: SPSE_1229
SPAS: STP1_0137
SHU: SHYC_06745(trmK)
SCAP: AYP1020_0858(trmK)
SSCH: LH95_05950
SSCZ: RN70_06130
SAGQ: EP23_03670
MCL: MCCL_1211
MCAK: MCCS_14970(trmK_1) MCCS_15360(trmK_2)
LMO: lmo1453
LMOE: BN418_1706
LMOB: BN419_1701
LMOD: LMON_1516
LMOW: AX10_01345
LMOQ: LM6179_2198(trmK)
LMR: LMR479A_1542(trmK)
LMOM: IJ09_02740
LMOG: BN389_14790(trmK)
LMP: MUO_07490
LMOX: AX24_04755
LMQ: LMM7_1538
LMS: LMLG_1669
LMOK: CQ02_07460
LIN: lin1490
LWE: lwe1468
LSG: lse_1370
LIV: LIV_1410
ESI: Exig_0834
EAN: Eab7_0806
GMO: NCTC11323_00454(trmK)
BBE: BBR47_20800(trmK)
PPY: PPE_03168
PPM: PPSC2_16800(yqfN)
PPO: PPM_3392(yqfN)
PPOL: X809_32845
PPOY: RE92_20295
PMW: B2K_28275
PLV: ERIC2_c25090(trmK)
PSAB: PSAB_17600
PRI: PRIO_5172
PSWU: SY83_14835
ASOC: CB4_01446(trmK)
AAC: Aaci_1975
AAD: TC41_2086
SIV: SSIL_2851
JEO: JMA_21660
LLA: L84257(ykiC)
LLK: LLKF_1100(ykiC)
LLT: CVCAS_1046(ykiC)
LLS: lilo_0975(ykiC)
LLC: LACR_1173
LLM: llmg_1500
LLR: llh_5875
LLW: kw2_1017
LLJ: LG36_1305
LGR: LCGT_1011
LGV: LCGL_1029
SPY: SPy_0930
SPYA: A20_0775
SPS: SPs1209
SPF: SpyM51076
SPYH: L897_03830
SPN: SP_1610
SPD: SPD_1435
SPR: spr1463
SPW: SPCG_1592
SJJ: SPJ_1517
SPX: SPG_1534
SNT: SPT_1551
SND: MYY_1541
SPNN: T308_07330
SPV: SPH_1724
SPP: SPP_1632
SNP: SPAP_1631
SAG: SAG1203
SAN: gbs1276
SAK: SAK_1290
SGC: A964_1176(trmK)
SAGM: BSA_12820
SAGI: MSA_13290
SAGR: SAIL_13210
SAGP: V193_05615
SAGC: DN94_05615
SAGE: EN72_06660
SAGG: EN73_06195
SAGN: W903_1287
SMU: SMU_1464c
SMUA: SMUFR_1270
STC: str1249
STL: stu1249
STE: STER_1228
STN: STND_1199
STW: Y1U_C1165
STHE: T303_07185
SSA: SSA_1417
SSI: SSU1136
SUP: YYK_05415
SSUY: YB51_3385
SSUT: TL13_0692
SSUI: T15_0661(trmK)
SGO: SGO_1005
SEZ: Sez_1241
SEQ: SZO_07230
SEQU: Q426_02925
SEU: SEQ_1422
SUB: SUB1125
SDS: SDEG_1275
SDA: GGS_1159
SDC: SDSE_1256
SGT: SGGB_0812
SMB: smi_0664
SOR: SOR_0603
STK: STP_0977
STB: SGPB_0690
SCF: Spaf_1356
SMN: SMA_0759
SIF: Sinf_0644
SIE: SCIM_0662
SIB: SIR_0943
SIU: SII_0960
SANG: SAIN_0650
SANC: SANR_0659
SANS: DK43_06905
SCG: SCI_1192
SCON: SCRE_1133
SCOS: SCR2_1133
SIK: K710_0762
SLU: KE3_0716
STRN: SNAG_0580(trmK)
LPL: lp_1906
LPJ: JDM1_1602
LPZ: Lp16_1476
LJO: LJ_1305
LJH: LJP_0881
LAC: LBA1192
LAD: LA14_1200
LAF: SD55_1192
LSA: LCA_0886
LSL: LSL_0846
LSI: HN6_00700
LSJ: LSJ_0866
LDB: Ldb1219
LBU: LBUL_1128
LDL: LBU_1038
LBR: LVIS_0759
LCA: LSEI_1500
LPAP: LBPC_1422
LCS: LCBD_1705
LCE: LC2W_1673
LCW: BN194_16910(trmK)
LGA: LGAS_1111
LRE: Lreu_0746
LRF: LAR_0717
LRT: LRI_1163
LHE: lhv_1293
LHL: LBHH_0868
LHV: lhe_1172
LHH: LBH_1058
LHD: HUO_05635
LFE: LAF_0863
LFF: LBFF_0912
LRH: LGG_01510(yqfN)
LRG: LRHM_1450
LRL: LC705_01525(yqfN)
LRA: LRHK_1511
LAM: LA2_06680
LBH: Lbuc_1023
LKE: WANG_0493
LRM: LRC_10450
LSN: LSA_07710(yqfN)
LAE: LBAT_0850
PPE: PEPE_1098
PPEN: T256_05400
PCE: PECL_888(trmK)
EFA: EF1380
EFL: EF62_1832
EFS: EFS1_1204
EFN: DENG_01542(trmK)
EFQ: DR75_454
ENE: ENT_08310
EFM: M7W_1312
EHR: EHR_11115
ECAS: ECBG_00879
EMU: EMQU_1543
EDU: LIU_09025
MPS: MPTP_0973
MPX: MPD5_0971
THL: TEH_14990
OOE: OEOE_0997
LME: LEUM_0770
LMM: MI1_03535
LMK: LMES_0694
LCI: LCK_00949
LKI: LKI_00980
WKO: WKK_00340
WCE: WS08_0710
WCT: WS74_0712
CRN: CAR_c11710(trmK)
CARC: NY10_597
JDA: BW727_100679(trmK)
CAC: CA_C1302
CAE: SMB_G1324(yqfN)
CAY: CEA_G1315
CPE: CPE2005
CPF: CPF_2262
CPR: CPR_1973
CTC: CTC_02008
CBO: CBO2936
CBA: CLB_2899
CBH: CLC_2831
CBY: CLM_3330
CBL: CLK_2320
CBK: CLL_A0915
CBB: CLD_1610
CBI: CLJ_B3192
CBN: CbC4_1811
CBT: CLH_0882
CBF: CLI_2988
CBM: CBF_2980
CBE: Cbei_0854
CBZ: Cbs_0854
CBEI: LF65_00935
CKL: CKL_0944
CKR: CKR_0857
CSR: Cspa_c09610(trmK)
CPAS: Clopa_2218
CPAT: CLPA_c22870(trmK)
CPAE: CPAST_c22870(trmK)
CSB: CLSA_c11090(trmK)
CBV: U729_24
CSQ: CSCA_3511
CLD: CLSPO_c30260(trmK)
CTYK: CTK_C24000
AMT: Amet_2991
AOE: Clos_1281
ASF: SFBM_0537
ASM: MOUSESFB_0502(trmA)
ASO: SFBmNL_00576(trmA)
ASB: RATSFB_0443(trmA)
CTH: Cthe_0893
HSC: HVS_09410(trmK)
CCE: Ccel_0543
CSS: Cst_c07990(trmK)
CSD: Clst_0763
ESR: ES1_06900
ESU: EUS_24000
CCEL: CCDG5_0926
RCH: RUM_15140
BPB: bpr_I0922
BFI: CIY_31410
BHU: bhn_I0807
RIX: RO1_39270
RIM: ROI_28260
COO: CCU_12700
CCT: CC1_16730
ROB: CK5_30030
RTO: RTO_18870
CPY: Cphy_3520
CSO: CLS_28420
BPRL: CL2_30660
HSD: SD1D_2023
CPRO: CPRO_01380(trmK)
ERT: EUR_27690
ERA: ERE_06360
CST: CLOST_1754(yqfN)
STH: STH597
SWO: Swol_0645
SLP: Slip_1592
DSY: DSY3046
DHD: Dhaf_4215
DRM: Dred_2460
DAE: Dtox_3035
PTH: PTH_0913
DAU: Daud_0496
SGY: Sgly_2399
HMO: HM1_1997
ELM: ELI_2049
EHL: EHLA_2156
OVA: OBV_22040
TMR: Tmar_2074
SAY: TPY_2842
CTHM: CFE_0974
BPRS: CK3_23250
TTE: TTE1754
THX: Thet_1590
TKI: TKV_c16230(trmK)
CHY: CHY_0459
MTA: Moth_0625
CSC: Csac_1731
ATE: Athe_1620
TOC: Toce_0934
TTM: Tthe_2011
TSH: Tsac_2475
FMA: FMG_0822
APR: Apre_1134
PMIC: NW74_03710
VPR: Vpar_1191
VRM: 44547418_01271(trmK)
MED: MELS_2098
MHG: MHY_21350
PUF: UFO1_2680
PFT: JBW_01901
AIN: Acin_0948
ERH: ERH_0967
MGE: MG_248
MGU: CM5_01440
MPN: MPN351(H91_orf213)
MPM: MPNA3510
MPJ: MPNE_0407
MPB: C985_0356
MPE: MYPE8350(MYPE8350)
MGA: MGA_0011
MGH: MGAH_0011
MGF: MGF_3214
MGZ: GCW_02185
MMY: MSC_0467
MMYM: MMS_A0517
MMYI: mycmycITA_00507(trmK)
MML: MLC_4480
MCP: MCAP_0502
MCAC: MCCP01_0584(trmK)
MCAP: MCCPF38_00595(trmK)
MCAR: MCCPILRI181_00594(trmK)
MCAI: MCCG_0585
MLC: MSB_A0516
MHA: HF1_01100
MHF: MHF_0129
MPF: MPUT_0329
MHE: MHC_00540
MWE: WEN_02805
MHB: MHM_01820
MPV: PRV_01790
MOV: OVS_01455
MGJ: MGM1_2400
MYT: MYE_01600(trmK)
UUR: UU350
UPA: UPA3_0366
UPR: UP3_c0387
HCR: X271_00331(trmK)
PAL: PA0612
NZS: SLY_0418
PSOL: S284_01990
ACL: ACL_0943
ABRA: BN85307200
APAL: BN85405910
AOC: Aocu_05360(trmK)
MFL: Mfl271
MTAB: MTABA_v1c02830(trmK)
MCOL: MCOLE_v1c02900(trmK)
ELJ: ELUMI_v1c06420(trmK)
ESX: ESOMN_v1c04040(trmK)
EFR: EFREU_v1c03550(trmK)
EML: EMELA_v1c03860(trmK)
SCR: SCHRY_v1c03310(trmK)
SSYR: SSYRP_v1c03500(trmK)
SDI: SDIMI_v3c05810(trmK)
STAI: STAIW_v1c08190(trmK)
SAPI: SAPIS_v1c06910(trmK)
SMIR: SMM_0815
SMIA: P344_04890
SCQ: SCULI_v1c07260(trmK)
SSAB: SSABA_v1c03240(trmK)
SATR: SATRI_v1c08820(trmK)
SERI: SERIO_v1c08590(trmK)
STUR: STURON_00282(trmK)
SLL: SLITO_v1c02970(trmK)
SCJ: SCANT_v1c07200(trmK)
SHJ: SHELI_v1c06640(trmK)
SFZ: SFLOR_v1c07760(trmK)
SCOU: SCORR_v1c02820(trmK)
SCLA: SCLARK_00842(trmK)
MBJ: KQ51_01132(trmK)
DRA: DR_0276
DGE: Dgeo_0009
MRB: Mrub_0102
RBA: RB10328
 » show all
Taxonomy
Reference
1  [PMID:20052680]
  Authors
Ta HM, Kim KK
  Title
Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine.
  Journal
Protein Sci 19:617-24 (2010)
DOI:10.1002/pro.319
Reference
2  [PMID:18420655]
  Authors
Roovers M, Kaminska KH, Tkaczuk KL, Gigot D, Droogmans L, Bujnicki JM
  Title
The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK).
  Journal
Nucleic Acids Res 36:3252-62 (2008)
DOI:10.1093/nar/gkn169
  Sequence
[bsu:BSU25180]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.217
IUBMB Enzyme Nomenclature: 2.1.1.217
ExPASy - ENZYME nomenclature database: 2.1.1.217
BRENDA, the Enzyme Database: 2.1.1.217

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