KEGG   ENZYME: 2.1.1.218Help
Entry
EC 2.1.1.218                Enzyme                                 

Name
tRNA (adenine9-N1)-methyltransferase;
Trm10p (ambiguous);
tRNA(m1G9/m1A9)-methyltransferase;
tRNA(m1G9/m1A9)MTase;
TK0422p (gene name);
tRNA m1A9-methyltransferase;
tRNA m1A9 Mtase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenine9 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N1-methyladenine9 in tRNA
Comment
The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase).
History
EC 2.1.1.218 created 2011 (EC 2.1.1.36 created 1972, part transferred 2011 to EC 2.1.1.218)
Orthology
K15566  tRNA (adenine9-N1/guanine9-N1)-methyltransferase
Genes
TAM: Theam_0430
DTE: Dester_0946
MKA: MK1026
AFU: AF_0031
AFG: AFULGI_00000290
APO: Arcpr_0444
AVE: Arcve_1658
AST: Asulf_00271
FPL: Ferp_2241
GAC: GACE_1058
GAH: GAH_01558
PHO: PH0711(PH0711)
PAB: PAB0880
PFU: PF0678
PFI: PFC_02550
PYN: PNA2_1359
PYS: Py04_0749
TKO: TK0422
TON: TON_0675
TGA: TGAM_0680
TSI: TSIB_0970
THE: GQS_01580
THA: TAM4_954
THM: CL1_2027
TLT: OCC_05461
THS: TES1_0839
TNU: BD01_0565
TEU: TEU_09285
PPAC: PAP_07635
APE: APE_0498
ACJ: ACAM_0386
IHO: Igni_0721
IIS: EYM_07625
IAG: Igag_1267
HBU: Hbut_0079
STO: STK_08530
SSO: SSO1087
SOL: Ssol_2061
SSOA: SULA_2093
SSOL: SULB_2094
SSOF: SULC_2092
SAI: Saci_1677
SID: M164_1128
SII: LD85_1255
SIH: SiH_1099
SIR: SiRe_1012
SIC: SiL_1021
MSE: Msed_1469
MCN: Mcup_0756
AHO: Ahos_0922
PAI: PAE0001
PIS: Pisl_0031
PCL: Pcal_0647
PAS: Pars_1096
PYR: P186_0834
POG: Pogu_1177
TNE: Tneu_0946
CMA: Cmaq_1633
TUZ: TUZN_0832
TTN: TTX_0355
VDI: Vdis_0727
VMO: VMUT_1574
ASC: ASAC_0477
ACIA: SE86_03265
NEQ: NEQ005
NAA: Nps_02650
 » show all
Taxonomy
Reference
1  [PMID:20525789]
  Authors
Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L
  Title
New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.
  Journal
Nucleic Acids Res 38:6533-43 (2010)
DOI:10.1093/nar/gkq451
  Sequence
[sai:Saci_1677] [tko:TK0422]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.218
IUBMB Enzyme Nomenclature: 2.1.1.218
ExPASy - ENZYME nomenclature database: 2.1.1.218
BRENDA, the Enzyme Database: 2.1.1.218

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