KEGG   ENZYME: 2.1.1.225Help
Entry
EC 2.1.1.225                Enzyme                                 

Name
tRNA:m4X modification enzyme;
TRM13;
Trm13p;
tRNA:Xm4 modification enzyme
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + cytidine4 in tRNAPro = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro;
(2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) = S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC);
(3) S-adenosyl-L-methionine + adenosine4 in tRNAHis = S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytidine4 in tRNAPro;
cytidine4 in tRNAGly(GCC);
adenosine4 in tRNAHis
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylcytidine4 in tRNAPro;
2'-O-methylcytidine4 in tRNAGly(GCC);
2'-O-methyladenosine4 in tRNAHis
Comment
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.
History
EC 2.1.1.225 created 2011
Orthology
K15446  tRNA:m4X modification enzyme
Genes
HSA: 54482(TRMT13)
PTR: 742372(TRMT13)
PPS: 100972211(TRMT13)
GGO: 101148351(TRMT13)
PON: 100456893(TRMT13)
NLE: 100580575(TRMT13)
MCC: 711396(TRMT13)
MCF: 102137915(TRMT13)
CSAB: 103224368(TRMT13)
RRO: 104673250(TRMT13)
RBB: 108524171(TRMT13) 108525930
CJC: 100391711(TRMT13)
SBQ: 101047705(TRMT13)
MMU: 229780(Trmt13)
RNO: 499697(Trmt13)
CGE: 100760563
HGL: 101721354(Trmt13)
CCAN: 109688165(Trmt13)
OCU: 100347251(TRMT13)
TUP: 102488274(TRMT13)
CFA: 479930(TRMT13)
AML: 100480930(TRMT13)
UMR: 103669334(TRMT13)
ORO: 101372186(TRMT13)
FCA: 101086829(TRMT13)
PTG: 102961454(TRMT13)
AJU: 106976410(TRMT13)
BTA: 614311(TRMT13)
BOM: 102272220(TRMT13)
BIU: 109556020(TRMT13)
PHD: 102341222(TRMT13)
CHX: 102177115(TRMT13)
OAS: 101112862(TRMT13)
SSC: 102167932(TRMT13)
CFR: 102516817(TRMT13)
CDK: 105084984(TRMT13)
BACU: 103003812(TRMT13)
LVE: 103086778(TRMT13)
OOR: 101282936(TRMT13)
ECB: 100050460(TRMT13)
EPZ: 103541514(TRMT13)
EAI: 106837784(TRMT13)
MYB: 102251850(TRMT13)
MYD: 102753968(TRMT13)
HAI: 109374612(TRMT13)
RSS: 109455456(TRMT13)
PALE: 102881835(TRMT13)
LAV: 100657527(TRMT13)
TMU: 101348709
MDO: 100032957(TRMT13)
SHR: 100913690(TRMT13)
OAA: 100081774(TRMT13)
GGA: 424470(TRMT13)
MGP: 100550808(TRMT13)
CJO: 107317455(TRMT13)
APLA: 101790226(TRMT13) 106016845
ACYG: 106039449(TRMT13)
TGU: 100230227(TRMT13)
GFR: 102042132(TRMT13)
FAB: 101821407(TRMT13)
PHI: 102105730(TRMT13)
PMAJ: 107208061(TRMT13)
CCW: 104695571(TRMT13)
FPG: 101911980(TRMT13)
FCH: 102055641(TRMT13)
CLV: 102092758(TRMT13)
EGZ: 104134029(TRMT13)
AAM: 106499749(TRMT13)
ASN: 102374605(TRMT13)
AMJ: 102560657(TRMT13)
PSS: 102444671(TRMT13)
CMY: 102929911(TRMT13)
CPIC: 101948973(TRMT13)
ACS: 100563797(trmt13)
PVT: 110076503(TRMT13)
PBI: 103056354(TRMT13)
GJA: 107112252(TRMT13)
XLA: 443770(trmt13.L)
XTR: 100379916(trmt13)
NPR: 108791472(TRMT13)
DRE: 541496(trmt13)
SRX: 107757496(trmt13)
SANH: 107669842(trmt13)
IPU: 108271181(trmt13)
AMEX: 103035609(trmt13)
TRU: 101064514(trmt13)
LCO: 104936348(trmt13)
MZE: 101468812(trmt13)
OLA: 101161965(trmt13)
XMA: 102231464(trmt13)
PRET: 103463270(trmt13)
NFU: 107395230(trmt13)
CSEM: 103398595(trmt13)
LCF: 108874169(trmt13)
HCQ: 109506849(trmt13)
BPEC: 110162795(trmt13)
SASA: 106573941(trmt13)
ELS: 105011372(trmt13)
SFM: 108919082(trmt13)
LCM: 102357633(TRMT13)
CMK: 103184743(trmt13)
DME: Dmel_CG18048(CG18048)
DSI: Dsimw501_GD19867(Dsim_GD19867)
MDE: 101892271
AAG: 5574527
AME: 724635
BIM: 100749688
BTER: 100643449
SOC: 105201117
AEC: 105145861
ACEP: 105618939
PBAR: 105432741
HST: 105189592
CFO: 105258870
LHU: 105675865
PGC: 109855194
NVI: 100121305
TCA: 657298
DPA: 109535473
NVL: 108563575
BMOR: 101740311
PMAC: 106715109
PRAP: 111002993
PXY: 105383650
ZNE: 110831270
FCD: 110858111
CEL: CELE_Y49A3A.3(Y49A3A.3)
CBR: CBG04631
BMY: Bm1_32655
CRG: 105347425
MYI: 110442823
OBI: 106872555
LAK: 106158403
SHX: MS3_00865
EPA: 110236250
ADF: 107342372
ATH: AT4G01880
CRB: 17883442
BRP: 103858799
BOE: 106331382
THJ: 104801320
CPAP: 110820615
CIT: 102630836
TCC: 18613778
GRA: 105795104
GHI: 107954388
DZI: 111304955
GMX: 100793810
VRA: 106776974
VAR: 108335159
CCAJ: 109791691
CAM: 101513602
LJA: Lj0g3v0339199.1(Lj0g3v0339199.1) Lj0g3v0339199.2(Lj0g3v0339199.2)
ADU: 107482805
AIP: 107638235
LANG: 109330456
FVE: 101314697
PPER: 18788080
PMUM: 103327274
PAVI: 110755772
ZJU: 107408669
CSV: 101215094
CMO: 103499984
MCHA: 111014027
CMAX: 111488184
CMOS: 111456639
CPEP: 111806667
RCU: 8265904
JCU: 105636539
JRE: 108980808
VVI: 100248556
SLY: 101261447
SPEN: 107011752
NSY: 104213533
INI: 109182502
SIND: 105162999
OEU: 111373193
HAN: 110899447
LSV: 111882767
DCR: 108211136
BVG: 104894806
SOE: 110776320
NNU: 104611248
OSA: 9267457
DOSA: Os03t0833200-01(Os03g0833200)
OBR: 102700415
BDI: 100823311
ATS: 109755505(LOC109755505)
SBI: 8079684
ZMA: 100272611
SITA: 101760264
PDA: 103721587
EGU: 105040026
MUS: 103983726
DCT: 110101281
AOF: 109831928
ATR: 18430065
PPP: 112274211
MIS: MICPUN_107426(CHP1)
APRO: F751_2767
SCE: YOL125W(TRM13)
ERC: Ecym_2047
KMX: KLMA_40390(TRM13)
NCS: NCAS_0C04580(NCAS0C04580)
NDI: NDAI_0G03950(NDAI0G03950)
TPF: TPHA_0P01340(TPHA0P01340)
TBL: TBLA_0B08620(TBLA0B08620)
TDL: TDEL_0E00570(TDEL0E00570)
KAF: KAFR_0C01700(KAFR0C01700)
CAL: CAALFM_CR00670CA(CaO19.7460)
CAUR: QG37_00429
SLB: AWJ20_904(TRM13)
SPO: SPAC1805.03c(trm13)
DFA: DFA_09068
EHI: EHI_083130(38.t00028)
CPV: cgd1_2810
SMIN: v1.2.021497.t1(symbB.v1.2.021497.t1) v1.2.021499.t1(symbB.v1.2.021499.t1)
SPAR: SPRG_19285
TCR: 509237.50
 » show all
Taxonomy
Reference
1  [PMID:17242307]
  Authors
Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM
  Title
The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4.
  Journal
RNA 13:404-13 (2007)
DOI:10.1261/rna.399607
  Sequence
[sce:YOL125W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.225
IUBMB Enzyme Nomenclature: 2.1.1.225
ExPASy - ENZYME nomenclature database: 2.1.1.225
BRENDA, the Enzyme Database: 2.1.1.225

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