KEGG   ENZYME: 2.1.1.229Help
Entry
EC 2.1.1.229                Enzyme                                 

Name
tRNA (carboxymethyluridine34-5-O)-methyltransferase;
ALKBH8;
ABH8;
Trm9;
tRNA methyltransferase 9
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (carboxymethyluridine34-5-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + carboxymethyluridine34 in tRNA = S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
carboxymethyluridine34 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-(2-methoxy-2-oxoethyl)uridine34 in tRNA
Comment
The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA.
History
EC 2.1.1.229 created 2011
Orthology
K10770  alkylated DNA repair protein alkB homolog 8
K15444  tRNA (uracil-5-)-methyltransferase TRM9
Genes
HSA: 91801(ALKBH8)
PTR: 466772(ALKBH8)
PPS: 100986393(ALKBH8)
GGO: 101146805(ALKBH8)
PON: 100443674(ALKBH8)
NLE: 100593027(ALKBH8) 100604945
MCC: 106993461(ALKBH8) 706917(ALKBH8)
MCF: 102129238(ALKBH8)
CSAB: 103248392(ALKBH8)
RRO: 104660492(ALKBH8)
RBB: 108517385(ALKBH8)
CJC: 100388487(ALKBH8)
SBQ: 101044794(ALKBH8)
MMU: 67667(Alkbh8)
RNO: 366783(Alkbh8)
CGE: 100760738(Alkbh8)
NGI: 103731325(Alkbh8)
HGL: 101705703(Alkbh8)
CCAN: 109700254(Alkbh8)
OCU: 100355593(ALKBH8)
TUP: 102497943(ALKBH8)
CFA: 489424(ALKBH8)
AML: 100466448(ALKBH8)
UMR: 103662428(ALKBH8)
ORO: 101375464(ALKBH8)
FCA: 101099745(ALKBH8)
PTG: 102961068(ALKBH8)
AJU: 106983930(ALKBH8)
BTA: 781788(ALKBH8)
BIU: 109569852(ALKBH8)
PHD: 102321838(ALKBH8)
CHX: 102188424(ALKBH8)
OAS: 101104088(ALKBH8) 105603922
SSC: 100626321(ALKBH8)
CFR: 102503738(ALKBH8)
CDK: 105104861(ALKBH8)
BACU: 102999435 103003035(ALKBH8)
LVE: 103088459(ALKBH8)
OOR: 101276479(ALKBH8)
ECB: 100061658(ALKBH8)
EPZ: 103564993(ALKBH8)
EAI: 106843661(ALKBH8)
MYB: 102256283(ALKBH8)
MYD: 102766171(ALKBH8)
HAI: 109371436(ALKBH8)
RSS: 109436846(ALKBH8)
PALE: 107196650
LAV: 100659555(ALKBH8)
TMU: 101360861
MDO: 100032528(ALKBH8)
SHR: 100925951(ALKBH8)
OAA: 100077668(ALKBH8)
GGA: 418972(ALKBH8)
MGP: 100541852 104909226(ALKBH8)
CJO: 107308365(ALKBH8)
APLA: 101804846(ALKBH8)
ACYG: 106047551(ALKBH8)
TGU: 100232062(ALKBH8)
GFR: 102044005(ALKBH8)
FAB: 101811495(ALKBH8)
PHI: 102113659(ALKBH8)
PMAJ: 107206743(ALKBH8)
CCAE: 111924140(ALKBH8)
CCW: 104690049(ALKBH8)
FPG: 101915946(ALKBH8)
FCH: 102058925(ALKBH8)
CLV: 102086962(ALKBH8)
EGZ: 104130053(ALKBH8)
AAM: 106493489(ALKBH8)
ASN: 102382297(ALKBH8)
AMJ: 102561181(ALKBH8)
PSS: 102443978(ALKBH8)
CMY: 102932808(ALKBH8)
CPIC: 101943831(ALKBH8)
ACS: 100555791(alkbh8)
PVT: 110084096(ALKBH8)
PBI: 103048090(ALKBH8) 103061622
GJA: 107118531(ALKBH8)
XLA: 108709989(alkbh8.S)
XTR: 550051(alkbh8)
NPR: 108796088(ALKBH8)
DRE: 556362(alkbh8)
SRX: 107719115
SANH: 107666883(alkbh8) 107686611
SGH: 107600490(alkbh8)
CCAR: 109064512(alkbh8)
IPU: 108256248(alkbh8)
AMEX: 103028213(alkbh8)
TRU: 101067875(alkbh8)
LCO: 104928517(alkbh8)
NCC: 104945138(alkbh8)
MZE: 101470566(alkbh8)
OLA: 101169473(alkbh8)
XMA: 102220910(alkbh8)
PRET: 103474500(alkbh8)
NFU: 107380437(alkbh8)
KMR: 108244647(alkbh8)
CSEM: 103378521(alkbh8)
LCF: 108890870(alkbh8)
SDU: 111224087(alkbh8)
HCQ: 109525529(alkbh8)
BPEC: 110174300(alkbh8)
MALB: 109971623(alkbh8)
SASA: 100195302(alkbh8)
OTW: 112267471(alkbh8)
ELS: 105024079(alkbh8)
SFM: 108924659(alkbh8)
LCM: 102356130(ALKBH8)
CMK: 103185771(alkbh8)
CIN: 100183670
APLC: 110977185
DME: Dmel_CG17807(CG17807)
DER: 6546676
DPE: 6590607
DSI: Dsimw501_GD25121(Dsim_GD25121)
DWI: 6646268
MDE: 101894009
AAG: 5567453
AME: 411649
BIM: 100746842
BTER: 100650876
SOC: 105193071
AEC: 105144255
ACEP: 105619235
PBAR: 105433077
HST: 105182053
DQU: 106743531
CFO: 105251336
LHU: 105668425
PGC: 109857915
PCF: 106785310
NVI: 100122369
MDL: 103574650
TCA: 663807
DPA: 109542362
NVL: 108562219
BMOR: 101736667
PMAC: 106709549
PRAP: 110998356
HAW: 110374414
PXY: 105386278
API: 100168657
CLEC: 106668903
ZNE: 110834248
FCD: 110860039
TUT: 107370080
CEL: CELE_C14B1.10(alkb-8)
BMY: Bm1_17050
CRG: 105318500
MYI: 110445761
OBI: 106878852
EGL: EGR_05611
EPA: 110252534
ADF: 107351190
HMG: 100207968
AQU: 100635888
ATH: AT1G31600(TRM9) AT1G36310
LJA: Lj0g3v0046209.1(Lj0g3v0046209.1) Lj0g3v0064359.1(Lj0g3v0064359.1) Lj2g3v1573010.1(Lj2g3v1573010.1) Lj2g3v1573010.2(Lj2g3v1573010.2)
OSA: 4330741
DOSA: Os02t0750500-01(Os02g0750500) Os04t0602700-00(Os04g0602700)
OBR: 102703096
ATS: 109741229(LOC109741229) 109760172(LOC109760172)
SBI: 8066423
AOF: 109832664
PPP: 112285437
MNG: MNEG_3576
APRO: F751_1394
SCE: YML014W(TRM9)
KMX: KLMA_40600(TRM9)
NCS: NCAS_0H02650(NCAS0H02650)
NDI: NDAI_0C00970(NDAI0C00970)
TPF: TPHA_0K00450(TPHA0K00450)
TBL: TBLA_0A06960(TBLA0A06960)
TDL: TDEL_0A04070(TDEL0A04070)
KAF: KAFR_0C05480(KAFR0C05480)
PIC: PICST_53251(TRM9)
CAL: CAALFM_CR08180CA(TRM9)
CAUR: QG37_00754
NTE: NEUTE1DRAFT74900(NEUTE1DRAFT_74900) NEUTE1DRAFT83783(NEUTE1DRAFT_83783)
MGR: MGG_14001
SSCK: SPSK_09477
MAW: MAC_06558
MAJ: MAA_07627
CMT: CCM_04762
BFU: BCIN_02g02290(Bctrm9)
MBE: MBM_02302
ANI: AN5119.2
ANG: ANI_1_1304064(An07g10200)
ABE: ARB_04238
TVE: TRV_05273
PTE: PTT_18672
SPO: SPAC13D6.03c(trm9)
ABP: AGABI1DRAFT97973(AGABI1DRAFT_97973)
ABV: AGABI2DRAFT148979(AGABI2DRAFT_148979)
DFA: DFA_09055
PYO: PY17X_0513200(PY02953)
PCB: PCHAS_051220(PC000396.02.0)
SMIN: v1.2.016030.t1(symbB.v1.2.016030.t1)
 » show all
Taxonomy
Reference
1  [PMID:20308323]
  Authors
Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD
  Title
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.
  Journal
Mol Cell Biol 30:2449-59 (2010)
DOI:10.1128/MCB.01604-09
  Sequence
[hsa:91801]
Reference
2  [PMID:20123966]
  Authors
Songe-Moller L, van den Born E, Leihne V, Vagbo CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PO, Klungland A
  Title
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
  Journal
Mol Cell Biol 30:1814-27 (2010)
DOI:10.1128/MCB.01602-09
Reference
3  [PMID:14645538]
  Authors
Kalhor HR, Clarke S
  Title
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.
  Journal
Mol Cell Biol 23:9283-92 (2003)
DOI:10.1128/MCB.23.24.9283-9292.2003
  Sequence
[sce:YML014W]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.229
IUBMB Enzyme Nomenclature: 2.1.1.229
ExPASy - ENZYME nomenclature database: 2.1.1.229
BRENDA, the Enzyme Database: 2.1.1.229

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