KEGG   ENZYME: 2.1.1.231Help
Entry
EC 2.1.1.231                Enzyme                                 

Name
flavonoid 4'-O-methyltransferase;
SOMT-2;
4'-hydroxyisoflavone methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 4'-hydroxyflavanone = S-adenosyl-L-homocysteine + a 4'-methoxyflavanone [RN:R09792]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4'-hydroxyflavanone [CPD:C19896]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4'-methoxyflavanone [CPD:C19895]
Comment
The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein.
History
EC 2.1.1.231 created 2011
Pathway
ec00941  Flavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K23053  flavonoid 4'-O-methyltransferase
Genes
GMX: 100776621(SOMT-2)
Taxonomy
Reference
1  [PMID:15961179]
  Authors
Kim DH, Kim BG, Lee Y, Ryu JY, Lim Y, Hur HG, Ahn JH
  Title
Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli.
  Journal
J Biotechnol 119:155-62 (2005)
DOI:10.1016/j.jbiotec.2005.04.004
  Sequence
[gmx:100776621]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.231
IUBMB Enzyme Nomenclature: 2.1.1.231
ExPASy - ENZYME nomenclature database: 2.1.1.231
BRENDA, the Enzyme Database: 2.1.1.231

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