KEGG   ENZYME: 2.1.1.236Help
Entry
EC 2.1.1.236                Enzyme                                 

Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase;
RavNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [RN:R09821]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19947]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19948]
Comment
The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.
History
EC 2.1.1.236 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20682  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Reference
1  [PMID:21264378]
  Authors
Kharel MK, Lian H, Rohr J
  Title
Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.
  Journal
Org Biomol Chem 9:1799-808 (2011)
DOI:10.1039/c0ob00854k
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.236
IUBMB Enzyme Nomenclature: 2.1.1.236
ExPASy - ENZYME nomenclature database: 2.1.1.236
BRENDA, the Enzyme Database: 2.1.1.236

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